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Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients.
PM R. 2012 May; 4(5 Suppl):S145-54.PM R

Abstract

Osteoarthritis (OA) is the most common cause of musculoskeletal disability in elderly individuals, and it places an enormous economic burden on society. Management of OA is primarily focused on palliative relief by using agents such as nonsteroidal anti-inflammatory drugs and analgesics. However, such an approach is limited by a narrow therapeutic focus that fails to address the progressive and multimodal nature of OA. Given the favorable safety profile of most nutritional interventions, identifying disease-modifying nutritional agents capable of improving symptoms and also preventing, slowing, or even reversing the degenerative process in OA should remain an important paradigm in translational and clinical research. Applying advances in nutritional science to musculoskeletal medicine remains challenging, given the fluid and dynamic nature of the field, along with a rapidly developing regulatory climate over manufacturing and commerce requirements. The aim of this article is to review the available literature on effectiveness and potential mechanism of macronutrients for OA, with a focus on the following: long-chain ω-3 essential fatty acids eicosapentaenoic acid and docosahexaenoic acid, functional ω-6 fatty acid γ-linolenic acid, and macronutrient composition of background diet. There also is a discussion about the concept of rational polysupplementation via the strategic integration of multiple nutraceuticals with potential complementary mechanisms for improving outcomes in OA. As applied nutritional science evolves, it will be important to stay on the forefront of proteomics, metabolomics, epigenetics, and nutrigenomics, because they hold enormous potential for developing novel therapeutic and prognostic breakthroughs in many areas of medicine, including OA.

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Authors+Show Affiliations

Lopez HL
The Center for Applied Health Sciences, LLC, 4302 Allen Road, Ste 120, Stow, OH, USA. hl@appliedhealthsciences.org

MeSH

AnimalsBody CompositionCartilage, ArticularDietary SupplementsDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, Omega-6Fish OilsHumansInflammationLipidsOsteoarthritisWeight Lossgamma-Linolenic Acid

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22632694

Citation

Lopez, Hector L.. "Nutritional Interventions to Prevent and Treat Osteoarthritis. Part I: Focus On Fatty Acids and Macronutrients." PM & R : the Journal of Injury, Function, and Rehabilitation, vol. 4, no. 5 Suppl, 2012, pp. S145-54.
Lopez HL. Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. PM R. 2012;4(5 Suppl):S145-54.
Lopez, H. L. (2012). Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. PM & R : the Journal of Injury, Function, and Rehabilitation, 4(5 Suppl), S145-54. https://doi.org/10.1016/j.pmrj.2012.02.022
Lopez HL. Nutritional Interventions to Prevent and Treat Osteoarthritis. Part I: Focus On Fatty Acids and Macronutrients. PM R. 2012;4(5 Suppl):S145-54. PubMed PMID: 22632694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. A1 - Lopez,Hector L, PY - 2012/02/27/received PY - 2012/02/27/accepted PY - 2012/5/29/entrez PY - 2012/6/1/pubmed PY - 2012/10/10/medline SP - S145 EP - 54 JF - PM & R : the journal of injury, function, and rehabilitation JO - PM R VL - 4 IS - 5 Suppl N2 - Osteoarthritis (OA) is the most common cause of musculoskeletal disability in elderly individuals, and it places an enormous economic burden on society. Management of OA is primarily focused on palliative relief by using agents such as nonsteroidal anti-inflammatory drugs and analgesics. However, such an approach is limited by a narrow therapeutic focus that fails to address the progressive and multimodal nature of OA. Given the favorable safety profile of most nutritional interventions, identifying disease-modifying nutritional agents capable of improving symptoms and also preventing, slowing, or even reversing the degenerative process in OA should remain an important paradigm in translational and clinical research. Applying advances in nutritional science to musculoskeletal medicine remains challenging, given the fluid and dynamic nature of the field, along with a rapidly developing regulatory climate over manufacturing and commerce requirements. The aim of this article is to review the available literature on effectiveness and potential mechanism of macronutrients for OA, with a focus on the following: long-chain ω-3 essential fatty acids eicosapentaenoic acid and docosahexaenoic acid, functional ω-6 fatty acid γ-linolenic acid, and macronutrient composition of background diet. There also is a discussion about the concept of rational polysupplementation via the strategic integration of multiple nutraceuticals with potential complementary mechanisms for improving outcomes in OA. As applied nutritional science evolves, it will be important to stay on the forefront of proteomics, metabolomics, epigenetics, and nutrigenomics, because they hold enormous potential for developing novel therapeutic and prognostic breakthroughs in many areas of medicine, including OA. SN - 1934-1563 UR - https://www.unboundmedicine.com/medline/citation/22632694/Nutritional_interventions_to_prevent_and_treat_osteoarthritis__Part_I:_focus_on_fatty_acids_and_macronutrients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1934-1482(12)00121-9 DB - PRIME DP - Unbound Medicine ER -