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Narrowband ultraviolet B three times per week is more effective in treating vitamin D deficiency than 1600 IU oral vitamin D₃ per day: a randomized clinical trial.
Br J Dermatol 2012; 167(3):625-30BJ

Abstract

BACKGROUND

It is known that narrowband ultraviolet B (NB-UVB) radiation and oral vitamin D(3) supplementation can both improve serum levels of vitamin D, expressed as 25-hydroxyvitamin D(3) [25(OH)D(3) ]. However, surprisingly few studies have compared the effects of the two interventions in treating vitamin D deficiency.

OBJECTIVES

To compare the effect of NB-UVB exposure with oral vitamin D(3) supplementation on vitamin D levels in patients with vitamin D deficiency.

METHODS

Seventy-three participants with vitamin D deficiency [25(OH)D(3) ≤ 25 nmol L(-1) ] were consecutively enrolled from February 2010 to May 2011, avoiding the summer period (June to September). The participants were randomized into two groups, one receiving full body NB-UVB exposure three times per week, the other receiving 1600 IU (40 μg) oral vitamin D(3) per day together with 1,000 mg calcium. Thirty-two participants completed the 6-week study period, 16 in each group. In both groups blood samples were obtained at baseline and after 3 and 6 weeks.

RESULTS

We found a significantly greater increase in 25(OH)D(3) levels (mean) in the NB-UVB treated group (from 19·2 to 75 nmol L(-1) ) compared with the oral vitamin D(3) treated group (from 23·3 to 60·6 nmol L(-1) ) after 6 weeks of treatment (P = 0·02), accompanied by a significant decrease in parathyroid hormone for the whole group (from 5·3 to 4·2 pmol L(-1) , P = 0·028).

CONCLUSIONS

Full body NB-UVB three times per week is more effective in treating vitamin D deficiency than prescription of a daily oral intake of 1600 IU (40 μg) vitamin D(3) .

Authors+Show Affiliations

Department of Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden. bogh@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22632734

Citation

Bogh, M K B., et al. "Narrowband Ultraviolet B Three Times Per Week Is More Effective in Treating Vitamin D Deficiency Than 1600 IU Oral Vitamin D₃ Per Day: a Randomized Clinical Trial." The British Journal of Dermatology, vol. 167, no. 3, 2012, pp. 625-30.
Bogh MK, Gullstrand J, Svensson A, et al. Narrowband ultraviolet B three times per week is more effective in treating vitamin D deficiency than 1600 IU oral vitamin D₃ per day: a randomized clinical trial. Br J Dermatol. 2012;167(3):625-30.
Bogh, M. K., Gullstrand, J., Svensson, A., Ljunggren, B., & Dorkhan, M. (2012). Narrowband ultraviolet B three times per week is more effective in treating vitamin D deficiency than 1600 IU oral vitamin D₃ per day: a randomized clinical trial. The British Journal of Dermatology, 167(3), pp. 625-30. doi:10.1111/j.1365-2133.2012.11069.x.
Bogh MK, et al. Narrowband Ultraviolet B Three Times Per Week Is More Effective in Treating Vitamin D Deficiency Than 1600 IU Oral Vitamin D₃ Per Day: a Randomized Clinical Trial. Br J Dermatol. 2012;167(3):625-30. PubMed PMID: 22632734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Narrowband ultraviolet B three times per week is more effective in treating vitamin D deficiency than 1600 IU oral vitamin D₃ per day: a randomized clinical trial. AU - Bogh,M K B, AU - Gullstrand,J, AU - Svensson,A, AU - Ljunggren,B, AU - Dorkhan,M, Y1 - 2012/08/20/ PY - 2012/5/29/entrez PY - 2012/5/29/pubmed PY - 2013/1/16/medline SP - 625 EP - 30 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 167 IS - 3 N2 - BACKGROUND: It is known that narrowband ultraviolet B (NB-UVB) radiation and oral vitamin D(3) supplementation can both improve serum levels of vitamin D, expressed as 25-hydroxyvitamin D(3) [25(OH)D(3) ]. However, surprisingly few studies have compared the effects of the two interventions in treating vitamin D deficiency. OBJECTIVES: To compare the effect of NB-UVB exposure with oral vitamin D(3) supplementation on vitamin D levels in patients with vitamin D deficiency. METHODS: Seventy-three participants with vitamin D deficiency [25(OH)D(3) ≤ 25 nmol L(-1) ] were consecutively enrolled from February 2010 to May 2011, avoiding the summer period (June to September). The participants were randomized into two groups, one receiving full body NB-UVB exposure three times per week, the other receiving 1600 IU (40 μg) oral vitamin D(3) per day together with 1,000 mg calcium. Thirty-two participants completed the 6-week study period, 16 in each group. In both groups blood samples were obtained at baseline and after 3 and 6 weeks. RESULTS: We found a significantly greater increase in 25(OH)D(3) levels (mean) in the NB-UVB treated group (from 19·2 to 75 nmol L(-1) ) compared with the oral vitamin D(3) treated group (from 23·3 to 60·6 nmol L(-1) ) after 6 weeks of treatment (P = 0·02), accompanied by a significant decrease in parathyroid hormone for the whole group (from 5·3 to 4·2 pmol L(-1) , P = 0·028). CONCLUSIONS: Full body NB-UVB three times per week is more effective in treating vitamin D deficiency than prescription of a daily oral intake of 1600 IU (40 μg) vitamin D(3) . SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/22632734/Narrowband_ultraviolet_B_three_times_per_week_is_more_effective_in_treating_vitamin_D_deficiency_than_1600_IU_oral_vitamin_D₃_per_day:_a_randomized_clinical_trial_ L2 - https://doi.org/10.1111/j.1365-2133.2012.11069.x DB - PRIME DP - Unbound Medicine ER -