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N-6 and n-3 fatty acid cholesteryl esters in relation to incident stroke in a Dutch adult population: a nested case-control study.
Nutr Metab Cardiovasc Dis. 2013 Aug; 23(8):737-43.NM

Abstract

BACKGROUND AND AIMS

There are few prospective studies on fatty acid status in relation to incident stroke, with inconsistent results. We assessed the associations of plasma n-6 and n-3 PUFA in cholesteryl esters with the risk of total stroke and stroke subtypes in Dutch adults.

METHODS AND RESULTS

We conducted a nested case-control study using data from a population-based cohort study in adults aged 20-65 years. Blood sampling and data collection took place during 1993-1997 and subjects were followed for 8-13 years. We identified 179 incident cases of stroke and 179 randomly selected controls, matched on age, gender, and enrollment date. Odds ratios (OR) with 95% confidence intervals (95%CI) were calculated per standard deviation (SD) increase of PUFA in cholesteryl esters using multivariable conditional logistic regression. Cases comprised 93 ischemic, 50 hemorrhagic, and 36 unspecified strokes. The n-6 PUFA linoleic acid and arachidonic acid contributed ~55% and ~6.5% respectively to total plasma fatty acids, whereas the n-3 PUFA alpha-linolenic acid contributed ~0.5% and eicosapentaenoic acid plus docosahexaenoic acid (EPA-DHA) ~1.3%. After adjustment for confounders, n-6 and n-3 PUFA were not associated with incident total stroke or stroke subtypes. The OR (95% CI) for total stroke was 0.95 (0.74-1.23) per SD increase in linoleic acid and 1.02 (0.80-1.30) per SD increase in arachidonic acid. ORs (95% CI) for total stroke were 0.94 (0.72-1.21) for alpha-linolenic acid and 1.16 (0.94-1.45) for EPA-DHA.

CONCLUSION

In the present study, plasma n-6 or n-3 fatty acids were not related to incident stroke or stroke subtypes.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22633188

Citation

De Goede, J, et al. "N-6 and N-3 Fatty Acid Cholesteryl Esters in Relation to Incident Stroke in a Dutch Adult Population: a Nested Case-control Study." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 23, no. 8, 2013, pp. 737-43.
De Goede J, Verschuren WM, Boer JM, et al. N-6 and n-3 fatty acid cholesteryl esters in relation to incident stroke in a Dutch adult population: a nested case-control study. Nutr Metab Cardiovasc Dis. 2013;23(8):737-43.
De Goede, J., Verschuren, W. M., Boer, J. M., Kromhout, D., & Geleijnse, J. M. (2013). N-6 and n-3 fatty acid cholesteryl esters in relation to incident stroke in a Dutch adult population: a nested case-control study. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 23(8), 737-43. https://doi.org/10.1016/j.numecd.2012.03.001
De Goede J, et al. N-6 and N-3 Fatty Acid Cholesteryl Esters in Relation to Incident Stroke in a Dutch Adult Population: a Nested Case-control Study. Nutr Metab Cardiovasc Dis. 2013;23(8):737-43. PubMed PMID: 22633188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - N-6 and n-3 fatty acid cholesteryl esters in relation to incident stroke in a Dutch adult population: a nested case-control study. AU - De Goede,J, AU - Verschuren,W M M, AU - Boer,J M A, AU - Kromhout,D, AU - Geleijnse,J M, Y1 - 2012/05/24/ PY - 2011/07/04/received PY - 2011/12/27/revised PY - 2012/03/07/accepted PY - 2012/5/29/entrez PY - 2012/5/29/pubmed PY - 2014/2/6/medline KW - CI KW - Cardiovascular disease KW - DHA KW - EPA KW - Epidemiology KW - MORGEN KW - Monitoring Project on Risk Factors for Chronic Diseases KW - OR KW - PUFA KW - Polyunsaturated fatty acids KW - SD KW - confidence interval KW - docosahexaenoic acid KW - eicosapentaenoic acid KW - odds ratio KW - polyunsaturated fatty acids KW - standard deviation SP - 737 EP - 43 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 23 IS - 8 N2 - BACKGROUND AND AIMS: There are few prospective studies on fatty acid status in relation to incident stroke, with inconsistent results. We assessed the associations of plasma n-6 and n-3 PUFA in cholesteryl esters with the risk of total stroke and stroke subtypes in Dutch adults. METHODS AND RESULTS: We conducted a nested case-control study using data from a population-based cohort study in adults aged 20-65 years. Blood sampling and data collection took place during 1993-1997 and subjects were followed for 8-13 years. We identified 179 incident cases of stroke and 179 randomly selected controls, matched on age, gender, and enrollment date. Odds ratios (OR) with 95% confidence intervals (95%CI) were calculated per standard deviation (SD) increase of PUFA in cholesteryl esters using multivariable conditional logistic regression. Cases comprised 93 ischemic, 50 hemorrhagic, and 36 unspecified strokes. The n-6 PUFA linoleic acid and arachidonic acid contributed ~55% and ~6.5% respectively to total plasma fatty acids, whereas the n-3 PUFA alpha-linolenic acid contributed ~0.5% and eicosapentaenoic acid plus docosahexaenoic acid (EPA-DHA) ~1.3%. After adjustment for confounders, n-6 and n-3 PUFA were not associated with incident total stroke or stroke subtypes. The OR (95% CI) for total stroke was 0.95 (0.74-1.23) per SD increase in linoleic acid and 1.02 (0.80-1.30) per SD increase in arachidonic acid. ORs (95% CI) for total stroke were 0.94 (0.72-1.21) for alpha-linolenic acid and 1.16 (0.94-1.45) for EPA-DHA. CONCLUSION: In the present study, plasma n-6 or n-3 fatty acids were not related to incident stroke or stroke subtypes. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/22633188/N_6_and_n_3_fatty_acid_cholesteryl_esters_in_relation_to_incident_stroke_in_a_Dutch_adult_population:_a_nested_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(12)00072-5 DB - PRIME DP - Unbound Medicine ER -