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Metabolic syndrome is associated with better nutritional status, but not with cardiovascular disease or all-cause mortality in patients on haemodialysis.
Arch Cardiovasc Dis. 2012 Apr; 105(4):211-7.AC

Abstract

BACKGROUND

Metabolic syndrome increases the risk of cardiovascular disease (CVD) and all-cause mortality in the general population.

AIMS

To investigate whether metabolic syndrome affects CVD and all-cause mortality in chronic haemodialysis patients.

METHODS

This prospective, observational cohort study was carried out at Peking university third hospital from June 2006 to June 2010. Baseline anthropometric and laboratory parameters were evaluated, and causes and times of mortality were documented. Nutritional status of the patients was assessed using subject global assessment (SGA) and serum albumin levels.

RESULTS

Of 162 haemodialysis patients recruited, five were lost to follow-up, leaving 157 in the final cohort, who were followed for 36-42 months. Mean age was 62 ± 11 years and 55.4% were men. Forty-six patients (30%) had metabolic syndrome. In the metabolic syndrome versus the non-metabolic syndrome group, there were fewer patients with malnutrition (by SGA) (15.2% vs. 55.0%; P < 0.001), but there were no significant differences in CVD mortality (8.7% vs. 10.8%; P = 0.9) or all-cause mortality (15.2% vs. 22.5%; P = 0.39), nor in mean observed survival time (30.8 ± 7.3 vs. 29.8 ± 8.5 months; P = 0.49) or total survival time (67 ± 43 vs. 78 ± 48 months; P = 0.20). Cox regression analysis showed that independent mortality risk factors were pre-existing CVD, age more than or equal to 66 years and serum albumin less than 37 g/L (indicating malnutrition).

CONCLUSION

Metabolic syndrome was associated with a better nutritional status, but not with CVD or all-cause mortality in the haemodialysis patients in this prospective cohort study.

Authors+Show Affiliations

Division of Nephrology, Peking University Third Hospital, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22633295

Citation

Xie, Qian, et al. "Metabolic Syndrome Is Associated With Better Nutritional Status, but Not With Cardiovascular Disease or All-cause Mortality in Patients On Haemodialysis." Archives of Cardiovascular Diseases, vol. 105, no. 4, 2012, pp. 211-7.
Xie Q, Zhang AH, Chen SY, et al. Metabolic syndrome is associated with better nutritional status, but not with cardiovascular disease or all-cause mortality in patients on haemodialysis. Arch Cardiovasc Dis. 2012;105(4):211-7.
Xie, Q., Zhang, A. H., Chen, S. Y., Lai, X., Zhang, F., He, L., Zhuang, Z., Zhu, N., Fan, M. H., & Wang, T. (2012). Metabolic syndrome is associated with better nutritional status, but not with cardiovascular disease or all-cause mortality in patients on haemodialysis. Archives of Cardiovascular Diseases, 105(4), 211-7. https://doi.org/10.1016/j.acvd.2012.01.012
Xie Q, et al. Metabolic Syndrome Is Associated With Better Nutritional Status, but Not With Cardiovascular Disease or All-cause Mortality in Patients On Haemodialysis. Arch Cardiovasc Dis. 2012;105(4):211-7. PubMed PMID: 22633295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome is associated with better nutritional status, but not with cardiovascular disease or all-cause mortality in patients on haemodialysis. AU - Xie,Qian, AU - Zhang,Ai-Hua, AU - Chen,Shao-Yan, AU - Lai,Xuan, AU - Zhang,Feng, AU - He,Lian, AU - Zhuang,Zhen, AU - Zhu,Ning, AU - Fan,Min-Hua, AU - Wang,Tao, Y1 - 2012/05/04/ PY - 2011/11/29/received PY - 2012/01/31/revised PY - 2012/01/31/accepted PY - 2012/5/29/entrez PY - 2012/5/29/pubmed PY - 2012/9/21/medline SP - 211 EP - 7 JF - Archives of cardiovascular diseases JO - Arch Cardiovasc Dis VL - 105 IS - 4 N2 - BACKGROUND: Metabolic syndrome increases the risk of cardiovascular disease (CVD) and all-cause mortality in the general population. AIMS: To investigate whether metabolic syndrome affects CVD and all-cause mortality in chronic haemodialysis patients. METHODS: This prospective, observational cohort study was carried out at Peking university third hospital from June 2006 to June 2010. Baseline anthropometric and laboratory parameters were evaluated, and causes and times of mortality were documented. Nutritional status of the patients was assessed using subject global assessment (SGA) and serum albumin levels. RESULTS: Of 162 haemodialysis patients recruited, five were lost to follow-up, leaving 157 in the final cohort, who were followed for 36-42 months. Mean age was 62 ± 11 years and 55.4% were men. Forty-six patients (30%) had metabolic syndrome. In the metabolic syndrome versus the non-metabolic syndrome group, there were fewer patients with malnutrition (by SGA) (15.2% vs. 55.0%; P < 0.001), but there were no significant differences in CVD mortality (8.7% vs. 10.8%; P = 0.9) or all-cause mortality (15.2% vs. 22.5%; P = 0.39), nor in mean observed survival time (30.8 ± 7.3 vs. 29.8 ± 8.5 months; P = 0.49) or total survival time (67 ± 43 vs. 78 ± 48 months; P = 0.20). Cox regression analysis showed that independent mortality risk factors were pre-existing CVD, age more than or equal to 66 years and serum albumin less than 37 g/L (indicating malnutrition). CONCLUSION: Metabolic syndrome was associated with a better nutritional status, but not with CVD or all-cause mortality in the haemodialysis patients in this prospective cohort study. SN - 1875-2128 UR - https://www.unboundmedicine.com/medline/citation/22633295/Metabolic_syndrome_is_associated_with_better_nutritional_status_but_not_with_cardiovascular_disease_or_all_cause_mortality_in_patients_on_haemodialysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1875-2136(12)00096-4 DB - PRIME DP - Unbound Medicine ER -