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Reduced serum levels of adiponectin in elderly patients with major depression.
J Psychiatr Res. 2012 Aug; 46(8):1081-5.JP

Abstract

Recent studies have implicated adiponectin and other adipocytokines in brain function, particularly in processes related to memory and cognition. Blood levels of adiponectin are reduced in patients with primary cognitive disorders, such as Alzheimer's disease and mild cognitive impairment, and in adult patients with major depression. The aim of the present study is to determine serum levels of adiponectin in a sample of elderly patients with major depressive disorder (MDD) as compared to healthy older adults, and to examine the correlations between adiponectin levels and parameters indicative of mood and cognitive state. We recruited fifty-one unmedicated outpatients with late-life depression (LLD) and 47 age-matched controls in this study. The diagnosis of MDD was made according to the DSM-IV criteria, and the severity of depressive episode was determined with the 21-item Hamilton Depression Scale (HDRS). Cognitive state was ascertained with the Cambridge Cognitive Test (CAMCOG) and the Mini-Mental State Examination (MMSE). Serum concentrations of adiponectin were determined using a sandwich ELISA method. Serum levels of adiponectin were significantly reduced in individuals with LLD (F = p < 0.001). Adiponectin level remained significantly reduced in after controlling for BMI index, scores on the CAMCOG, MMSE and HDRS and educational level (p < 0.001). Adiponectin levels showed a negative correlation with HDRS scores (r = -0.59, p < 0.001) and BMI index (r = -0.42, p < 0.001); and showed a positive correlation with CAMCOG (r = 0.34, p < 0.01) and MMSE scores (r = 0.20, p = 0.05). The availability of circulating adiponectin is reduced in older adults with major depression, with likely implications on cognitive and mood state. Additional studies are required to determine whether this abnormality pertains to the pathophysiology of geriatric depression per se, or is a consequence of the morbid state.

Authors+Show Affiliations

Laboratory of Neuroscience (LIM 27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. brenosatler@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22633396

Citation

Diniz, Breno S., et al. "Reduced Serum Levels of Adiponectin in Elderly Patients With Major Depression." Journal of Psychiatric Research, vol. 46, no. 8, 2012, pp. 1081-5.
Diniz BS, Teixeira AL, Campos AC, et al. Reduced serum levels of adiponectin in elderly patients with major depression. J Psychiatr Res. 2012;46(8):1081-5.
Diniz, B. S., Teixeira, A. L., Campos, A. C., Miranda, A. S., Rocha, N. P., Talib, L. L., Gattaz, W. F., & Forlenza, O. V. (2012). Reduced serum levels of adiponectin in elderly patients with major depression. Journal of Psychiatric Research, 46(8), 1081-5. https://doi.org/10.1016/j.jpsychires.2012.04.028
Diniz BS, et al. Reduced Serum Levels of Adiponectin in Elderly Patients With Major Depression. J Psychiatr Res. 2012;46(8):1081-5. PubMed PMID: 22633396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced serum levels of adiponectin in elderly patients with major depression. AU - Diniz,Breno S, AU - Teixeira,Antonio L, AU - Campos,Alline C, AU - Miranda,Aline S, AU - Rocha,Natalia P, AU - Talib,Leda L, AU - Gattaz,Wagner F, AU - Forlenza,Orestes V, Y1 - 2012/05/25/ PY - 2012/03/11/received PY - 2012/04/23/revised PY - 2012/04/26/accepted PY - 2012/5/29/entrez PY - 2012/5/29/pubmed PY - 2012/12/10/medline SP - 1081 EP - 5 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 46 IS - 8 N2 - Recent studies have implicated adiponectin and other adipocytokines in brain function, particularly in processes related to memory and cognition. Blood levels of adiponectin are reduced in patients with primary cognitive disorders, such as Alzheimer's disease and mild cognitive impairment, and in adult patients with major depression. The aim of the present study is to determine serum levels of adiponectin in a sample of elderly patients with major depressive disorder (MDD) as compared to healthy older adults, and to examine the correlations between adiponectin levels and parameters indicative of mood and cognitive state. We recruited fifty-one unmedicated outpatients with late-life depression (LLD) and 47 age-matched controls in this study. The diagnosis of MDD was made according to the DSM-IV criteria, and the severity of depressive episode was determined with the 21-item Hamilton Depression Scale (HDRS). Cognitive state was ascertained with the Cambridge Cognitive Test (CAMCOG) and the Mini-Mental State Examination (MMSE). Serum concentrations of adiponectin were determined using a sandwich ELISA method. Serum levels of adiponectin were significantly reduced in individuals with LLD (F = p < 0.001). Adiponectin level remained significantly reduced in after controlling for BMI index, scores on the CAMCOG, MMSE and HDRS and educational level (p < 0.001). Adiponectin levels showed a negative correlation with HDRS scores (r = -0.59, p < 0.001) and BMI index (r = -0.42, p < 0.001); and showed a positive correlation with CAMCOG (r = 0.34, p < 0.01) and MMSE scores (r = 0.20, p = 0.05). The availability of circulating adiponectin is reduced in older adults with major depression, with likely implications on cognitive and mood state. Additional studies are required to determine whether this abnormality pertains to the pathophysiology of geriatric depression per se, or is a consequence of the morbid state. SN - 1879-1379 UR - https://www.unboundmedicine.com/medline/citation/22633396/Reduced_serum_levels_of_adiponectin_in_elderly_patients_with_major_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(12)00142-2 DB - PRIME DP - Unbound Medicine ER -