Tags

Type your tag names separated by a space and hit enter

A woman with thyrotoxicosis- and hyperemesis gravidarum-associated Wernicke's encephalopathy.
Neuro Endocrinol Lett. 2012; 33(3):285-9.NE

Abstract

Although hyperthyroidism arising from primary thyroid disease is rare in pregnancy, transient gestational hyperthyroidism is not uncommon. This condition can be associated with hyperemesis gravidarum (HG), and Wernicke's encephalopathy. We present the case of a woman with toxic nodular goiter complicating HG-associated Wernicke's encephalopathy. A 38-year-old Caucasian woman, who had received a diagnosis of hyperthyroidism and HG early in her pregnancy, had intrauterine fetal death at Week 16 of gestation. One day after undergoing therapeutic abortion, she was admitted to our clinic with persistent thyrotoxicosis, nausea, and vomiting. A toxic thyroid nodule was detected. She was given antithyroid medication, total parenteral nutrition. On Day 10 of hospitalization, she developed ataxia, aphasia, and somnolence. Cranial magnetic resonance imaging showed increased bilateral thalamic signalization. She was given a diagnosis of Wernicke's metabolic encephalopathy, for which she received thiamine and multivitamin preparations. She responded dramatically on the second day of thiamine therapy. Her consciousness improved rapidly and she began to speak. Her muscle tone was slightly weak and she had paresthesias in both legs. Absorption of thiamine may be particularly impaired in pregnant women with hyperemesis and hyperthyroid disease. Wernicke's encephalopathy should be considered in hyperthyroid women with HG who develop neurological abnormalities.

Authors+Show Affiliations

Anaforoğlu İ
Department of Endocrinology and Metabolism, Trabzon Numune Education and Research Hospital, Trabzon, Turkey. ianaforoglu@hotmail.com
Yildiz B
No affiliation info available
İnceçayir Ö
No affiliation info available
Algün E
No affiliation info available

MeSH

AdultFemaleGoiter, NodularHumansHyperemesis GravidarumPregnancyRadionuclide ImagingThiamineThyrotoxicosisVitamin B ComplexWernicke Encephalopathy

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22635085

Citation

Anaforoğlu, İnan, et al. "A Woman With Thyrotoxicosis- and Hyperemesis Gravidarum-associated Wernicke's Encephalopathy." Neuro Endocrinology Letters, vol. 33, no. 3, 2012, pp. 285-9.
Anaforoğlu İ, Yildiz B, İnceçayir Ö, et al. A woman with thyrotoxicosis- and hyperemesis gravidarum-associated Wernicke's encephalopathy. Neuro Endocrinol Lett. 2012;33(3):285-9.
Anaforoğlu, İ., Yildiz, B., İnceçayir, Ö., & Algün, E. (2012). A woman with thyrotoxicosis- and hyperemesis gravidarum-associated Wernicke's encephalopathy. Neuro Endocrinology Letters, 33(3), 285-9.
Anaforoğlu İ, et al. A Woman With Thyrotoxicosis- and Hyperemesis Gravidarum-associated Wernicke's Encephalopathy. Neuro Endocrinol Lett. 2012;33(3):285-9. PubMed PMID: 22635085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A woman with thyrotoxicosis- and hyperemesis gravidarum-associated Wernicke's encephalopathy. AU - Anaforoğlu,İnan, AU - Yildiz,Bülent, AU - İnceçayir,Ömer, AU - Algün,Ekrem, PY - 2012/05/10/received PY - 2012/05/14/accepted PY - 2012/5/29/entrez PY - 2012/5/29/pubmed PY - 2012/8/15/medline SP - 285 EP - 9 JF - Neuro endocrinology letters JO - Neuro Endocrinol Lett VL - 33 IS - 3 N2 - Although hyperthyroidism arising from primary thyroid disease is rare in pregnancy, transient gestational hyperthyroidism is not uncommon. This condition can be associated with hyperemesis gravidarum (HG), and Wernicke's encephalopathy. We present the case of a woman with toxic nodular goiter complicating HG-associated Wernicke's encephalopathy. A 38-year-old Caucasian woman, who had received a diagnosis of hyperthyroidism and HG early in her pregnancy, had intrauterine fetal death at Week 16 of gestation. One day after undergoing therapeutic abortion, she was admitted to our clinic with persistent thyrotoxicosis, nausea, and vomiting. A toxic thyroid nodule was detected. She was given antithyroid medication, total parenteral nutrition. On Day 10 of hospitalization, she developed ataxia, aphasia, and somnolence. Cranial magnetic resonance imaging showed increased bilateral thalamic signalization. She was given a diagnosis of Wernicke's metabolic encephalopathy, for which she received thiamine and multivitamin preparations. She responded dramatically on the second day of thiamine therapy. Her consciousness improved rapidly and she began to speak. Her muscle tone was slightly weak and she had paresthesias in both legs. Absorption of thiamine may be particularly impaired in pregnant women with hyperemesis and hyperthyroid disease. Wernicke's encephalopathy should be considered in hyperthyroid women with HG who develop neurological abnormalities. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/22635085/A_woman_with_thyrotoxicosis__and_hyperemesis_gravidarum_associated_Wernicke's_encephalopathy_ DB - PRIME DP - Unbound Medicine ER -