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Association between the chemokine receptor 5 delta32 polymorphism and rheumatoid arthritis: a meta-analysis.
Mod Rheumatol. 2013 Mar; 23(2):304-10.MR

Abstract

OBJECTIVE

The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism confers susceptibility to rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).

METHODS

Meta-analysis was conducted on associations between the CCR5-Δ32 polymorphism and RA and JIA using (1) allele contrast and (2) the recessive, (3) the dominant, and (4) the additive models.

RESULTS

Eleven population comparisons based on the data obtained from nine studies involving 13,412 subjects (RA 3,848, controls 4,095; JIA 1,599, controls 3,870) were considered. In all study subjects, meta-analysis showed a significant negative association between RA and the CCR5-Δ32 allele (OR = 0.771, 95 % CI = 0.694-0.866, p = 6.5 × 10(-7)). Stratification by ethnicity indicated a significant association between the CCR5-Δ32 allele and RA in Europeans (OR = 0.8001, 95 % CI = 0.709-0.904, p = 3.2 × 10(-5)). Meta-analysis showed associations between the CCR5-Δ32 allele and JIA in Europeans and oligoarticular type (OR = 0.797, 95 % CI = 0.690-0.921, p = 0.002; OR = 0.475, 95 % CI = 0.352-0.693, p = 9.5 × 10(-8)).

CONCLUSIONS

This meta-analysis demonstrates that the CCR5-Δ32 polymorphism may confer susceptibility to RA and JIA in Europeans, and suggests that the CCR5-Δ32 allele protects against the development of RA and JIA.

Authors+Show Affiliations

Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea. lyhcgh@korea.ac.krNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22638733

Citation

Lee, Young Ho, et al. "Association Between the Chemokine Receptor 5 Delta32 Polymorphism and Rheumatoid Arthritis: a Meta-analysis." Modern Rheumatology, vol. 23, no. 2, 2013, pp. 304-10.
Lee YH, Bae SC, Song GG. Association between the chemokine receptor 5 delta32 polymorphism and rheumatoid arthritis: a meta-analysis. Mod Rheumatol. 2013;23(2):304-10.
Lee, Y. H., Bae, S. C., & Song, G. G. (2013). Association between the chemokine receptor 5 delta32 polymorphism and rheumatoid arthritis: a meta-analysis. Modern Rheumatology, 23(2), 304-10. https://doi.org/10.1007/s10165-012-0665-2
Lee YH, Bae SC, Song GG. Association Between the Chemokine Receptor 5 Delta32 Polymorphism and Rheumatoid Arthritis: a Meta-analysis. Mod Rheumatol. 2013;23(2):304-10. PubMed PMID: 22638733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between the chemokine receptor 5 delta32 polymorphism and rheumatoid arthritis: a meta-analysis. AU - Lee,Young Ho, AU - Bae,Sang-Cheol, AU - Song,Gwan Gyu, Y1 - 2012/05/27/ PY - 2012/03/08/received PY - 2012/04/20/accepted PY - 2012/5/29/entrez PY - 2012/5/29/pubmed PY - 2013/8/31/medline SP - 304 EP - 10 JF - Modern rheumatology JO - Mod Rheumatol VL - 23 IS - 2 N2 - OBJECTIVE: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism confers susceptibility to rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). METHODS: Meta-analysis was conducted on associations between the CCR5-Δ32 polymorphism and RA and JIA using (1) allele contrast and (2) the recessive, (3) the dominant, and (4) the additive models. RESULTS: Eleven population comparisons based on the data obtained from nine studies involving 13,412 subjects (RA 3,848, controls 4,095; JIA 1,599, controls 3,870) were considered. In all study subjects, meta-analysis showed a significant negative association between RA and the CCR5-Δ32 allele (OR = 0.771, 95 % CI = 0.694-0.866, p = 6.5 × 10(-7)). Stratification by ethnicity indicated a significant association between the CCR5-Δ32 allele and RA in Europeans (OR = 0.8001, 95 % CI = 0.709-0.904, p = 3.2 × 10(-5)). Meta-analysis showed associations between the CCR5-Δ32 allele and JIA in Europeans and oligoarticular type (OR = 0.797, 95 % CI = 0.690-0.921, p = 0.002; OR = 0.475, 95 % CI = 0.352-0.693, p = 9.5 × 10(-8)). CONCLUSIONS: This meta-analysis demonstrates that the CCR5-Δ32 polymorphism may confer susceptibility to RA and JIA in Europeans, and suggests that the CCR5-Δ32 allele protects against the development of RA and JIA. SN - 1439-7609 UR - https://www.unboundmedicine.com/medline/citation/22638733/Association_between_the_chemokine_receptor_5_delta32_polymorphism_and_rheumatoid_arthritis:_a_meta_analysis_ L2 - https://dx.doi.org/10.1007/s10165-012-0665-2 DB - PRIME DP - Unbound Medicine ER -