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Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersions.
Drug Dev Ind Pharm. 2013 May; 39(5):704-15.DD

Abstract

Formulation of solid dispersions is one of the effective methods to increase the rate of solubilization and dissolution of poorly soluble drugs. Solid dispersions of chloramphenicol (CP) and sulphamethoxazole (SX) as model drugs were prepared by melt fusion method using polyethylene glycol 8000 (PEG 8000) as an inert carrier. The dissolution rate of CP and SX were rapid from solid dispersions with low drug and high polymer content. Characterization was performed using fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). FTIR analysis for the solid dispersions of CP and SX showed that there was no interaction between PEG 8000 and the drugs. Hyper-DSC studies revealed that CP and SX were converted into an amorphous form when formulated as solid dispersion in PEG 8000. Mathematical analysis of the release kinetics demonstrated that drug release from the various formulations followed different mechanisms. Permeability studies demonstrated that both CP and SX when formulated as solid dispersions showed enhanced permeability across Caco-2 cells and CP can be classified as well-absorbed compound when formulated as solid dispersions.

Authors+Show Affiliations

Aston Pharmacy School, Aston University, Birmingham, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22639985

Citation

Khan, Sheraz, et al. "Dissolution Rate Enhancement, in Vitro Evaluation and Investigation of Drug Release Kinetics of Chloramphenicol and Sulphamethoxazole Solid Dispersions." Drug Development and Industrial Pharmacy, vol. 39, no. 5, 2013, pp. 704-15.
Khan S, Batchelor H, Hanson P, et al. Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersions. Drug Dev Ind Pharm. 2013;39(5):704-15.
Khan, S., Batchelor, H., Hanson, P., Saleem, I. Y., Perrie, Y., & Mohammed, A. R. (2013). Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersions. Drug Development and Industrial Pharmacy, 39(5), 704-15. https://doi.org/10.3109/03639045.2012.689763
Khan S, et al. Dissolution Rate Enhancement, in Vitro Evaluation and Investigation of Drug Release Kinetics of Chloramphenicol and Sulphamethoxazole Solid Dispersions. Drug Dev Ind Pharm. 2013;39(5):704-15. PubMed PMID: 22639985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersions. AU - Khan,Sheraz, AU - Batchelor,Hannah, AU - Hanson,Peter, AU - Saleem,Imran Y, AU - Perrie,Yvonne, AU - Mohammed,Afzal R, Y1 - 2012/05/29/ PY - 2012/5/30/entrez PY - 2012/5/30/pubmed PY - 2013/10/25/medline SP - 704 EP - 15 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 39 IS - 5 N2 - Formulation of solid dispersions is one of the effective methods to increase the rate of solubilization and dissolution of poorly soluble drugs. Solid dispersions of chloramphenicol (CP) and sulphamethoxazole (SX) as model drugs were prepared by melt fusion method using polyethylene glycol 8000 (PEG 8000) as an inert carrier. The dissolution rate of CP and SX were rapid from solid dispersions with low drug and high polymer content. Characterization was performed using fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). FTIR analysis for the solid dispersions of CP and SX showed that there was no interaction between PEG 8000 and the drugs. Hyper-DSC studies revealed that CP and SX were converted into an amorphous form when formulated as solid dispersion in PEG 8000. Mathematical analysis of the release kinetics demonstrated that drug release from the various formulations followed different mechanisms. Permeability studies demonstrated that both CP and SX when formulated as solid dispersions showed enhanced permeability across Caco-2 cells and CP can be classified as well-absorbed compound when formulated as solid dispersions. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/22639985/Dissolution_rate_enhancement_in_vitro_evaluation_and_investigation_of_drug_release_kinetics_of_chloramphenicol_and_sulphamethoxazole_solid_dispersions_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2012.689763 DB - PRIME DP - Unbound Medicine ER -