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Structural correlates of facial emotion recognition deficits in Parkinson's disease patients.
Neuropsychologia. 2012 Jul; 50(8):2121-8.N

Abstract

The ability to recognize facial emotion expressions, especially negative ones, is described to be impaired in Parkinson's disease (PD) patients. Previous neuroimaging work evaluating the neural substrate of facial emotion recognition (FER) in healthy and pathological subjects has mostly focused on functional changes. This study was designed to evaluate gray matter (GM) and white matter (WM) correlates of FER in a large sample of PD. Thirty-nine PD patients and 23 healthy controls (HC) were tested with the Ekman 60 test for FER and with magnetic resonance imaging. Effects of associated depressive symptoms were taken into account. In accordance with previous studies, PD patients performed significantly worse in recognizing sadness, anger and disgust. In PD patients, voxel-based morphometry analysis revealed areas of positive correlation between individual emotion recognition and GM volume: in the right orbitofrontal cortex, amygdala and postcentral gyrus and sadness identification; in the right occipital fusiform gyrus, ventral striatum and subgenual cortex and anger identification, and in the anterior cingulate cortex (ACC) and disgust identification. WM analysis through diffusion tensor imaging revealed significant positive correlations between fractional anisotropy levels in the frontal portion of the right inferior fronto-occipital fasciculus and the performance in the identification of sadness. These findings shed light on the structural neural bases of the deficits presented by PD patients in this skill.

Authors+Show Affiliations

Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22640663

Citation

Baggio, H C., et al. "Structural Correlates of Facial Emotion Recognition Deficits in Parkinson's Disease Patients." Neuropsychologia, vol. 50, no. 8, 2012, pp. 2121-8.
Baggio HC, Segura B, Ibarretxe-Bilbao N, et al. Structural correlates of facial emotion recognition deficits in Parkinson's disease patients. Neuropsychologia. 2012;50(8):2121-8.
Baggio, H. C., Segura, B., Ibarretxe-Bilbao, N., Valldeoriola, F., Marti, M. J., Compta, Y., Tolosa, E., & Junqué, C. (2012). Structural correlates of facial emotion recognition deficits in Parkinson's disease patients. Neuropsychologia, 50(8), 2121-8. https://doi.org/10.1016/j.neuropsychologia.2012.05.020
Baggio HC, et al. Structural Correlates of Facial Emotion Recognition Deficits in Parkinson's Disease Patients. Neuropsychologia. 2012;50(8):2121-8. PubMed PMID: 22640663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structural correlates of facial emotion recognition deficits in Parkinson's disease patients. AU - Baggio,H C, AU - Segura,B, AU - Ibarretxe-Bilbao,N, AU - Valldeoriola,F, AU - Marti,M J, AU - Compta,Y, AU - Tolosa,E, AU - Junqué,C, Y1 - 2012/05/26/ PY - 2011/10/19/received PY - 2012/05/16/revised PY - 2012/05/20/accepted PY - 2012/5/30/entrez PY - 2012/5/30/pubmed PY - 2012/12/10/medline SP - 2121 EP - 8 JF - Neuropsychologia JO - Neuropsychologia VL - 50 IS - 8 N2 - The ability to recognize facial emotion expressions, especially negative ones, is described to be impaired in Parkinson's disease (PD) patients. Previous neuroimaging work evaluating the neural substrate of facial emotion recognition (FER) in healthy and pathological subjects has mostly focused on functional changes. This study was designed to evaluate gray matter (GM) and white matter (WM) correlates of FER in a large sample of PD. Thirty-nine PD patients and 23 healthy controls (HC) were tested with the Ekman 60 test for FER and with magnetic resonance imaging. Effects of associated depressive symptoms were taken into account. In accordance with previous studies, PD patients performed significantly worse in recognizing sadness, anger and disgust. In PD patients, voxel-based morphometry analysis revealed areas of positive correlation between individual emotion recognition and GM volume: in the right orbitofrontal cortex, amygdala and postcentral gyrus and sadness identification; in the right occipital fusiform gyrus, ventral striatum and subgenual cortex and anger identification, and in the anterior cingulate cortex (ACC) and disgust identification. WM analysis through diffusion tensor imaging revealed significant positive correlations between fractional anisotropy levels in the frontal portion of the right inferior fronto-occipital fasciculus and the performance in the identification of sadness. These findings shed light on the structural neural bases of the deficits presented by PD patients in this skill. SN - 1873-3514 UR - https://www.unboundmedicine.com/medline/citation/22640663/Structural_correlates_of_facial_emotion_recognition_deficits_in_Parkinson's_disease_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3932(12)00222-9 DB - PRIME DP - Unbound Medicine ER -