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Pigment epithelium-derived factor, insulin sensitivity, and adiposity in polycystic ovary syndrome: impact of exercise training.
Obesity (Silver Spring). 2012 Dec; 20(12):2390-6.O

Abstract

Pigment epithelium-derived factor (PEDF) is upregulated in obese rodents and is involved in the development of insulin resistance (IR). We aim to explore the relationships between PEDF, adiposity, insulin sensitivity, and cardiovascular risk factors in obese women with polycystic ovary syndrome (PCOS) and weight-matched controls and to examine the impact of endurance exercise training on PEDF. This prospective cohort intervention study was based at a tertiary medical center. Twenty obese PCOS women and 14 non-PCOS weight-matched women were studied at baseline. PEDF, cardiometabolic markers, detailed body composition, and euglycemic-hyperinsulinemic clamps were performed and measures were repeated in 10 PCOS and 8 non-PCOS women following 12 weeks of intensified aerobic exercise. Mean glucose infusion rate (GIR) was 31.7% lower (P = 0.02) in PCOS compared to controls (175.6 ± 96.3 and 257.2 ± 64.3 mg.m(-2).min(-1)) at baseline, yet both PEDF and BMI were similar between groups. PEDF negatively correlated to GIR (r = -0.41, P = 0.03) and high-density lipoprotein (HDL) (r = -0.46, P = 0.01), and positively to cardiovascular risk factors, systolic (r = 0.41, P = 0.02) and diastolic blood pressure (r = 0.47, P = 0.01) and triglycerides (r = 0.49, P = 0.004). The correlation with GIR was not significant after adjusting for fat mass (P = 0.07). Exercise training maintained BMI and increased GIR in both groups; however, plasma PEDF was unchanged. In summary, PEDF is not elevated in PCOS, is not associated with IR when adjusted for fat mass, and is not reduced by endurance exercise training despite improved insulin sensitivity. PEDF was associated with cardiovascular risk factors, suggesting PEDF may be a marker of cardiovascular risk status.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Joham AE
Women's Public Health Research, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Teede HJ
No affiliation info available
Hutchison SK
No affiliation info available
Stepto NK
No affiliation info available
Harrison CL
No affiliation info available
Strauss BJ
No affiliation info available
Paul E
No affiliation info available
Watt MJ
No affiliation info available

MeSH

AdultBiomarkersBody CompositionBody Mass IndexCardiovascular DiseasesExerciseEye ProteinsFemaleGlucose Clamp TechniqueHumansInsulin ResistanceLipoproteins, HDLLipoproteins, IDLNerve Growth FactorsObesityPolycystic Ovary SyndromeProspective StudiesSerpinsTime FactorsTriglycerides

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22641183

Citation

Joham, Anju E., et al. "Pigment Epithelium-derived Factor, Insulin Sensitivity, and Adiposity in Polycystic Ovary Syndrome: Impact of Exercise Training." Obesity (Silver Spring, Md.), vol. 20, no. 12, 2012, pp. 2390-6.
Joham AE, Teede HJ, Hutchison SK, et al. Pigment epithelium-derived factor, insulin sensitivity, and adiposity in polycystic ovary syndrome: impact of exercise training. Obesity (Silver Spring). 2012;20(12):2390-6.
Joham, A. E., Teede, H. J., Hutchison, S. K., Stepto, N. K., Harrison, C. L., Strauss, B. J., Paul, E., & Watt, M. J. (2012). Pigment epithelium-derived factor, insulin sensitivity, and adiposity in polycystic ovary syndrome: impact of exercise training. Obesity (Silver Spring, Md.), 20(12), 2390-6. https://doi.org/10.1038/oby.2012.135
Joham AE, et al. Pigment Epithelium-derived Factor, Insulin Sensitivity, and Adiposity in Polycystic Ovary Syndrome: Impact of Exercise Training. Obesity (Silver Spring). 2012;20(12):2390-6. PubMed PMID: 22641183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pigment epithelium-derived factor, insulin sensitivity, and adiposity in polycystic ovary syndrome: impact of exercise training. AU - Joham,Anju E, AU - Teede,Helena J, AU - Hutchison,Samantha K, AU - Stepto,Nigel K, AU - Harrison,Cheryce L, AU - Strauss,Boyd J, AU - Paul,Eldho, AU - Watt,Matthew J, Y1 - 2012/05/29/ PY - 2012/5/30/entrez PY - 2012/5/30/pubmed PY - 2013/6/12/medline SP - 2390 EP - 6 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 20 IS - 12 N2 - Pigment epithelium-derived factor (PEDF) is upregulated in obese rodents and is involved in the development of insulin resistance (IR). We aim to explore the relationships between PEDF, adiposity, insulin sensitivity, and cardiovascular risk factors in obese women with polycystic ovary syndrome (PCOS) and weight-matched controls and to examine the impact of endurance exercise training on PEDF. This prospective cohort intervention study was based at a tertiary medical center. Twenty obese PCOS women and 14 non-PCOS weight-matched women were studied at baseline. PEDF, cardiometabolic markers, detailed body composition, and euglycemic-hyperinsulinemic clamps were performed and measures were repeated in 10 PCOS and 8 non-PCOS women following 12 weeks of intensified aerobic exercise. Mean glucose infusion rate (GIR) was 31.7% lower (P = 0.02) in PCOS compared to controls (175.6 ± 96.3 and 257.2 ± 64.3 mg.m(-2).min(-1)) at baseline, yet both PEDF and BMI were similar between groups. PEDF negatively correlated to GIR (r = -0.41, P = 0.03) and high-density lipoprotein (HDL) (r = -0.46, P = 0.01), and positively to cardiovascular risk factors, systolic (r = 0.41, P = 0.02) and diastolic blood pressure (r = 0.47, P = 0.01) and triglycerides (r = 0.49, P = 0.004). The correlation with GIR was not significant after adjusting for fat mass (P = 0.07). Exercise training maintained BMI and increased GIR in both groups; however, plasma PEDF was unchanged. In summary, PEDF is not elevated in PCOS, is not associated with IR when adjusted for fat mass, and is not reduced by endurance exercise training despite improved insulin sensitivity. PEDF was associated with cardiovascular risk factors, suggesting PEDF may be a marker of cardiovascular risk status. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/22641183/Pigment_epithelium_derived_factor_insulin_sensitivity_and_adiposity_in_polycystic_ovary_syndrome:_impact_of_exercise_training_ DB - PRIME DP - Unbound Medicine ER -