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Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition.
Pediatrics 2012; 129(6):1141-9Ped

Abstract

BACKGROUND AND OBJECTIVE

Infant formula is supplemented with long-chain polyunsaturated fatty acids (LCPUFAs) because they are hypothesized to improve cognition. Several randomized controlled clinical trials have examined the effect of LCPUFA supplementation of infant formula on cognitive development. We conducted this meta-analysis to examine the efficacy of LCPUFA supplementation of infant formula on early cognitive development.

METHODS

Two authors searched PubMed, PsychInfo, and Scopus for randomized controlled clinical trials assessing the efficacy of LCPUFA supplementation of infant formulas on cognition. Our analysis was restricted to randomized controlled clinical trials that examined the effect of LCPUFA supplementation on infant cognition using Bayley Scales of Infant Development. Our primary outcome was the weighted mean difference in Bayley Scales of Infant Development score between infants fed formula supplemented with LCPUFA compared with unsupplemented formula. We conducted secondary subgroup analyses and meta-regression to examine the effects of study sample, LCPUFA dose, and trial methodologic quality on measured efficacy of supplementation.

RESULTS

Twelve trials involving 1802 infants met our inclusion criteria. Our meta-analysis demonstrated no significant effect of LCPUFA supplementation of formula on infant cognition. There was no significant heterogeneity or publication bias between trials. Secondary analysis failed to show any significant effect of LCPUFA dosing or prematurity status on supplementation efficacy.

CONCLUSIONS

LCPUFA supplementation of infant formulas failed to show any significant effect on improving early infant cognition. Further research is needed to determine if LCPUFA supplementation of infant formula has benefits for later cognitive development or other measures of neurodevelopment.

Authors+Show Affiliations

Yale Child Study Center, Yale University, New Haven, Connecticut 06520, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22641753

Citation

Qawasmi, Ahmad, et al. "Meta-analysis of Long-chain Polyunsaturated Fatty Acid Supplementation of Formula and Infant Cognition." Pediatrics, vol. 129, no. 6, 2012, pp. 1141-9.
Qawasmi A, Landeros-Weisenberger A, Leckman JF, et al. Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition. Pediatrics. 2012;129(6):1141-9.
Qawasmi, A., Landeros-Weisenberger, A., Leckman, J. F., & Bloch, M. H. (2012). Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition. Pediatrics, 129(6), pp. 1141-9. doi:10.1542/peds.2011-2127.
Qawasmi A, et al. Meta-analysis of Long-chain Polyunsaturated Fatty Acid Supplementation of Formula and Infant Cognition. Pediatrics. 2012;129(6):1141-9. PubMed PMID: 22641753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition. AU - Qawasmi,Ahmad, AU - Landeros-Weisenberger,Angeli, AU - Leckman,James F, AU - Bloch,Michael H, Y1 - 2012/05/28/ PY - 2012/5/30/entrez PY - 2012/5/30/pubmed PY - 2012/8/8/medline SP - 1141 EP - 9 JF - Pediatrics JO - Pediatrics VL - 129 IS - 6 N2 - BACKGROUND AND OBJECTIVE: Infant formula is supplemented with long-chain polyunsaturated fatty acids (LCPUFAs) because they are hypothesized to improve cognition. Several randomized controlled clinical trials have examined the effect of LCPUFA supplementation of infant formula on cognitive development. We conducted this meta-analysis to examine the efficacy of LCPUFA supplementation of infant formula on early cognitive development. METHODS: Two authors searched PubMed, PsychInfo, and Scopus for randomized controlled clinical trials assessing the efficacy of LCPUFA supplementation of infant formulas on cognition. Our analysis was restricted to randomized controlled clinical trials that examined the effect of LCPUFA supplementation on infant cognition using Bayley Scales of Infant Development. Our primary outcome was the weighted mean difference in Bayley Scales of Infant Development score between infants fed formula supplemented with LCPUFA compared with unsupplemented formula. We conducted secondary subgroup analyses and meta-regression to examine the effects of study sample, LCPUFA dose, and trial methodologic quality on measured efficacy of supplementation. RESULTS: Twelve trials involving 1802 infants met our inclusion criteria. Our meta-analysis demonstrated no significant effect of LCPUFA supplementation of formula on infant cognition. There was no significant heterogeneity or publication bias between trials. Secondary analysis failed to show any significant effect of LCPUFA dosing or prematurity status on supplementation efficacy. CONCLUSIONS: LCPUFA supplementation of infant formulas failed to show any significant effect on improving early infant cognition. Further research is needed to determine if LCPUFA supplementation of infant formula has benefits for later cognitive development or other measures of neurodevelopment. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/22641753/Meta_analysis_of_long_chain_polyunsaturated_fatty_acid_supplementation_of_formula_and_infant_cognition_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=22641753 DB - PRIME DP - Unbound Medicine ER -