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Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea.
J Ethnopharmacol. 2012 Jul 13; 142(2):539-47.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The extract from the stem bark of Garcinia buchananii trees is used as an anti-diarrhea remedy in sub-Saharan Africa. We tested the hypothesis that G. buchananii bark extract and its anti-motility fractions are effective treatments against lactose-induced diarrhea.

MATERIALS AND METHODS

A high-lactose (35%) diet was used to induce diarrhea in Wistar rats, which were then treated with either G. buchananii bark extract (0.1, 0.5, 1.0 and 5.0 g bark powder), and its anti-motility fractions isolated using preparative thin layer chromatography; termed PTLC1 (15 mg) and PTLC5 (3.8 mg) or loperamide (8.4 mg). Drug preparations were dissolved in 1L except PTCL1 and PTLC5 that were dissolved in 100mL tap water. Numerous parameters were measured in each condition including consistency, fluid and mucus content of feces, body weight, water and food consumption, urine production and bloating.

RESULTS

Diarrheic rats produced watery or loose, mucuoid, sticky, feces. Fluids constituted 86% of stool mass compared with only 42% for control rats fed standard chow. Compared with controls, diarrheic rats produced more urine, lost weight and had bloated ceca and colons. All doses of the extract, its anti-motility fractions and loperamide individually stopped diarrhea within 6-24 h of administration, whilst significantly reducing mucus and fecal fluid content, urine production and intestinal bloating. Rats treated with 0.1g extract, PTLC1 and PTLC5 gained weight, whilst PTLC5 also increased water intake.

CONCLUSIONS

Garcinia buchananii extract and its anti-motility fractions are effective remedies against lactose-induced diarrhea. The extract contains compounds that reverse weight loss, promote food and water intake, supporting the notion that characterization of the compounds could lead to new therapies against diarrheal diseases.

Authors+Show Affiliations

Department of Biological Sciences, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22643232

Citation

Boakye, Paul A., et al. "Garcinia Buchananii Bark Extract Is an Effective Anti-diarrheal Remedy for Lactose-induced Diarrhea." Journal of Ethnopharmacology, vol. 142, no. 2, 2012, pp. 539-47.
Boakye PA, Brierley SM, Pasilis SP, et al. Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea. J Ethnopharmacol. 2012;142(2):539-47.
Boakye, P. A., Brierley, S. M., Pasilis, S. P., & Balemba, O. B. (2012). Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea. Journal of Ethnopharmacology, 142(2), 539-47. https://doi.org/10.1016/j.jep.2012.05.034
Boakye PA, et al. Garcinia Buchananii Bark Extract Is an Effective Anti-diarrheal Remedy for Lactose-induced Diarrhea. J Ethnopharmacol. 2012 Jul 13;142(2):539-47. PubMed PMID: 22643232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea. AU - Boakye,Paul A, AU - Brierley,Stuart M, AU - Pasilis,Sofie P, AU - Balemba,Onesmo B, Y1 - 2012/05/27/ PY - 2011/10/28/received PY - 2012/03/17/revised PY - 2012/05/20/accepted PY - 2012/5/31/entrez PY - 2012/5/31/pubmed PY - 2012/10/24/medline SP - 539 EP - 47 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 142 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The extract from the stem bark of Garcinia buchananii trees is used as an anti-diarrhea remedy in sub-Saharan Africa. We tested the hypothesis that G. buchananii bark extract and its anti-motility fractions are effective treatments against lactose-induced diarrhea. MATERIALS AND METHODS: A high-lactose (35%) diet was used to induce diarrhea in Wistar rats, which were then treated with either G. buchananii bark extract (0.1, 0.5, 1.0 and 5.0 g bark powder), and its anti-motility fractions isolated using preparative thin layer chromatography; termed PTLC1 (15 mg) and PTLC5 (3.8 mg) or loperamide (8.4 mg). Drug preparations were dissolved in 1L except PTCL1 and PTLC5 that were dissolved in 100mL tap water. Numerous parameters were measured in each condition including consistency, fluid and mucus content of feces, body weight, water and food consumption, urine production and bloating. RESULTS: Diarrheic rats produced watery or loose, mucuoid, sticky, feces. Fluids constituted 86% of stool mass compared with only 42% for control rats fed standard chow. Compared with controls, diarrheic rats produced more urine, lost weight and had bloated ceca and colons. All doses of the extract, its anti-motility fractions and loperamide individually stopped diarrhea within 6-24 h of administration, whilst significantly reducing mucus and fecal fluid content, urine production and intestinal bloating. Rats treated with 0.1g extract, PTLC1 and PTLC5 gained weight, whilst PTLC5 also increased water intake. CONCLUSIONS: Garcinia buchananii extract and its anti-motility fractions are effective remedies against lactose-induced diarrhea. The extract contains compounds that reverse weight loss, promote food and water intake, supporting the notion that characterization of the compounds could lead to new therapies against diarrheal diseases. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22643232/Garcinia_buchananii_bark_extract_is_an_effective_anti_diarrheal_remedy_for_lactose_induced_diarrhea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00344-3 DB - PRIME DP - Unbound Medicine ER -