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Evaluation of propranolol for prevention of recurrent bleeding from esophageal varices between sclerotherapy sessions.
Acta Chir Scand. 1990 Oct; 156(10):711-5.AC

Abstract

Forty-one patients admitted with first episode of bleeding from esophageal varices were enrolled in a trial of the efficacy of oral propranolol to prevent rebleeding during the course of endoscopic sclerotherapy until obliteration. Single-blind randomization to sclerotherapy alone or with propranolol was used. At monthly endoscopy the varices were injected with 1% Aethoxysclerol until obliteration. If bleeding recurred, additional sclerotherapy was given. There was no intergroup difference in time to eradication of varices (8.1 vs. 7.7 months). The cumulative number of bleedings from varices and from distal esophageal ulcerations was identical in the two study groups. Five patients in the control group but only one in the propranolol group died of bleeding in the study period, a difference of only borderline significance (chi 2 = 4.08, df = 1). There were no specific side effects of propranolol. Thus propranolol did not significantly reduce the frequency of rebleeding until variceal obliteration, but could have had some influence on the gravity of rebleeding.

Authors+Show Affiliations

Department of Surgery, Sahlgren's Hospital, University of Göteborg, Gothenborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2264429

Citation

Lundell, L, et al. "Evaluation of Propranolol for Prevention of Recurrent Bleeding From Esophageal Varices Between Sclerotherapy Sessions." Acta Chirurgica Scandinavica, vol. 156, no. 10, 1990, pp. 711-5.
Lundell L, Leth R, Lind T, et al. Evaluation of propranolol for prevention of recurrent bleeding from esophageal varices between sclerotherapy sessions. Acta Chir Scand. 1990;156(10):711-5.
Lundell, L., Leth, R., Lind, T., Lönroth, H., Sjövall, M., & Olbe, L. (1990). Evaluation of propranolol for prevention of recurrent bleeding from esophageal varices between sclerotherapy sessions. Acta Chirurgica Scandinavica, 156(10), 711-5.
Lundell L, et al. Evaluation of Propranolol for Prevention of Recurrent Bleeding From Esophageal Varices Between Sclerotherapy Sessions. Acta Chir Scand. 1990;156(10):711-5. PubMed PMID: 2264429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of propranolol for prevention of recurrent bleeding from esophageal varices between sclerotherapy sessions. AU - Lundell,L, AU - Leth,R, AU - Lind,T, AU - Lönroth,H, AU - Sjövall,M, AU - Olbe,L, PY - 1990/10/1/pubmed PY - 1990/10/1/medline PY - 1990/10/1/entrez SP - 711 EP - 5 JF - Acta chirurgica Scandinavica JO - Acta Chir Scand VL - 156 IS - 10 N2 - Forty-one patients admitted with first episode of bleeding from esophageal varices were enrolled in a trial of the efficacy of oral propranolol to prevent rebleeding during the course of endoscopic sclerotherapy until obliteration. Single-blind randomization to sclerotherapy alone or with propranolol was used. At monthly endoscopy the varices were injected with 1% Aethoxysclerol until obliteration. If bleeding recurred, additional sclerotherapy was given. There was no intergroup difference in time to eradication of varices (8.1 vs. 7.7 months). The cumulative number of bleedings from varices and from distal esophageal ulcerations was identical in the two study groups. Five patients in the control group but only one in the propranolol group died of bleeding in the study period, a difference of only borderline significance (chi 2 = 4.08, df = 1). There were no specific side effects of propranolol. Thus propranolol did not significantly reduce the frequency of rebleeding until variceal obliteration, but could have had some influence on the gravity of rebleeding. SN - 0001-5482 UR - https://www.unboundmedicine.com/medline/citation/2264429/Evaluation_of_propranolol_for_prevention_of_recurrent_bleeding_from_esophageal_varices_between_sclerotherapy_sessions_ L2 - https://www.diseaseinfosearch.org/result/2658 DB - PRIME DP - Unbound Medicine ER -