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Taurodontism in Brazilian patients with tooth agenesis and first and second-degree relatives: a case-control study.
Arch Oral Biol. 2012 Aug; 57(8):1062-9.AO

Abstract

AIM

An association between tooth agenesis and taurodontism has been suggested. To verify if tooth agenesis and taurodontism are associated within families and specific patterns of tooth agenesis, this study aims to compare the frequency of taurodontism in patients with nonsyndromic familial tooth agenesis, their first and second-degree relatives with complete permanent dentition and a control group of unrelated healthy individuals with complete permanent dentition.

MATERIALS AND METHODS

Panoramic radiographs of patients with nonsyndromic familial tooth agenesis, their first and second-degree relatives and a control group of individuals with complete permanent dentition were examined. Taurodontism was assessed on permanent mandibular first molars. The difference in the frequency of taurodontism among the studied groups was tested with Fisher's Exact Test.

RESULTS

Seventeen families with nonsyndromic familial tooth agenesis were studied. The frequency of taurodontism was 29% in patients with tooth agenesis, 10.3% in their first and second degree relatives, and 6.6% in the control group. A significant statistical difference among the studied groups was observed (p=0.002). Taurodontism was proportionally more frequent in patients with a higher number of absent teeth. It was mainly observed in patients from families in which the proband was diagnosed with oligodontia.

CONCLUSIONS

Taurodontism is more frequent in nonsyndromic familial tooth agenesis. Individuals in families with second premolar and molar oligodontia are more likely to have taurodontism, even the individuals with complete dentition. This association could define a subphenotype for future genetic studies of dental development.

Authors+Show Affiliations

Oral Care Center for Inherited Diseases, University Hospital of Brasilia, Department of Dentistry, School of Health Science, University of Brasilia, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22647425

Citation

Gomes, Raquel R., et al. "Taurodontism in Brazilian Patients With Tooth Agenesis and First and Second-degree Relatives: a Case-control Study." Archives of Oral Biology, vol. 57, no. 8, 2012, pp. 1062-9.
Gomes RR, Habckost CD, Junqueira LG, et al. Taurodontism in Brazilian patients with tooth agenesis and first and second-degree relatives: a case-control study. Arch Oral Biol. 2012;57(8):1062-9.
Gomes, R. R., Habckost, C. D., Junqueira, L. G., Leite, A. F., Figueiredo, P. T., Paula, L. M., & Acevedo, A. C. (2012). Taurodontism in Brazilian patients with tooth agenesis and first and second-degree relatives: a case-control study. Archives of Oral Biology, 57(8), 1062-9. https://doi.org/10.1016/j.archoralbio.2012.04.006
Gomes RR, et al. Taurodontism in Brazilian Patients With Tooth Agenesis and First and Second-degree Relatives: a Case-control Study. Arch Oral Biol. 2012;57(8):1062-9. PubMed PMID: 22647425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Taurodontism in Brazilian patients with tooth agenesis and first and second-degree relatives: a case-control study. AU - Gomes,Raquel R, AU - Habckost,Clarissa D, AU - Junqueira,Larissa G, AU - Leite,André F, AU - Figueiredo,Paulo T, AU - Paula,Lílian M, AU - Acevedo,Ana C, Y1 - 2012/05/28/ PY - 2011/08/23/received PY - 2012/04/12/revised PY - 2012/04/22/accepted PY - 2012/6/1/entrez PY - 2012/6/1/pubmed PY - 2013/2/15/medline SP - 1062 EP - 9 JF - Archives of oral biology JO - Arch. Oral Biol. VL - 57 IS - 8 N2 - AIM: An association between tooth agenesis and taurodontism has been suggested. To verify if tooth agenesis and taurodontism are associated within families and specific patterns of tooth agenesis, this study aims to compare the frequency of taurodontism in patients with nonsyndromic familial tooth agenesis, their first and second-degree relatives with complete permanent dentition and a control group of unrelated healthy individuals with complete permanent dentition. MATERIALS AND METHODS: Panoramic radiographs of patients with nonsyndromic familial tooth agenesis, their first and second-degree relatives and a control group of individuals with complete permanent dentition were examined. Taurodontism was assessed on permanent mandibular first molars. The difference in the frequency of taurodontism among the studied groups was tested with Fisher's Exact Test. RESULTS: Seventeen families with nonsyndromic familial tooth agenesis were studied. The frequency of taurodontism was 29% in patients with tooth agenesis, 10.3% in their first and second degree relatives, and 6.6% in the control group. A significant statistical difference among the studied groups was observed (p=0.002). Taurodontism was proportionally more frequent in patients with a higher number of absent teeth. It was mainly observed in patients from families in which the proband was diagnosed with oligodontia. CONCLUSIONS: Taurodontism is more frequent in nonsyndromic familial tooth agenesis. Individuals in families with second premolar and molar oligodontia are more likely to have taurodontism, even the individuals with complete dentition. This association could define a subphenotype for future genetic studies of dental development. SN - 1879-1506 UR - https://www.unboundmedicine.com/medline/citation/22647425/Taurodontism_in_Brazilian_patients_with_tooth_agenesis_and_first_and_second_degree_relatives:_a_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9969(12)00130-6 DB - PRIME DP - Unbound Medicine ER -