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Effects of pomegranate juice supplementation on pulse wave velocity and blood pressure in healthy young and middle-aged men and women.
Plant Foods Hum Nutr 2012; 67(3):309-14PF

Abstract

Pomegranate juice may improve cardiovascular risk because of its content of antioxidant polyphenols. We conducted a randomized placebo-controlled parallel study to examine the effect of pomegranate juice on pulse wave velocity (PWV), blood pressure (BP) and plasma antioxidant status (ferric reducing power; FRAP) in 51 healthy adults (30-50 years). Participants consumed 330 ml/day of pomegranate juice or control drink for four weeks. Measurements were made at baseline and at four weeks. There was no effect of the intervention on PWV (P = 0.694) and plasma FRAP (P = 0.700). However, there was a significant fall in systolic blood pressure (-3.14 mmHg, P < 0.001), diastolic blood pressure (-2.33 mmHg P < 0.001) and mean arterial pressure (-2.60 mmHg, P < 0.001). Change in weight was similar in the two groups over the intervention period (P = 0.379). The fall in BP was not paralleled by changes in concentration of serum angiotensin converting enzyme. We conclude that pomegranate juice supplementation has benefits for BP in the short term, but has no effect on PWV. The mechanism for the effect is uncertain.

Authors+Show Affiliations

Sheffield Hallam University, Sheffield, South Yorkshire, UK. T.Lynn@shu.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22648092

Citation

Lynn, Anthony, et al. "Effects of Pomegranate Juice Supplementation On Pulse Wave Velocity and Blood Pressure in Healthy Young and Middle-aged Men and Women." Plant Foods for Human Nutrition (Dordrecht, Netherlands), vol. 67, no. 3, 2012, pp. 309-14.
Lynn A, Hamadeh H, Leung WC, et al. Effects of pomegranate juice supplementation on pulse wave velocity and blood pressure in healthy young and middle-aged men and women. Plant Foods Hum Nutr. 2012;67(3):309-14.
Lynn, A., Hamadeh, H., Leung, W. C., Russell, J. M., & Barker, M. E. (2012). Effects of pomegranate juice supplementation on pulse wave velocity and blood pressure in healthy young and middle-aged men and women. Plant Foods for Human Nutrition (Dordrecht, Netherlands), 67(3), pp. 309-14.
Lynn A, et al. Effects of Pomegranate Juice Supplementation On Pulse Wave Velocity and Blood Pressure in Healthy Young and Middle-aged Men and Women. Plant Foods Hum Nutr. 2012;67(3):309-14. PubMed PMID: 22648092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of pomegranate juice supplementation on pulse wave velocity and blood pressure in healthy young and middle-aged men and women. AU - Lynn,Anthony, AU - Hamadeh,Hiba, AU - Leung,Wing Chi, AU - Russell,Jean M, AU - Barker,Margo E, PY - 2012/6/1/entrez PY - 2012/6/1/pubmed PY - 2013/2/6/medline SP - 309 EP - 14 JF - Plant foods for human nutrition (Dordrecht, Netherlands) JO - Plant Foods Hum Nutr VL - 67 IS - 3 N2 - Pomegranate juice may improve cardiovascular risk because of its content of antioxidant polyphenols. We conducted a randomized placebo-controlled parallel study to examine the effect of pomegranate juice on pulse wave velocity (PWV), blood pressure (BP) and plasma antioxidant status (ferric reducing power; FRAP) in 51 healthy adults (30-50 years). Participants consumed 330 ml/day of pomegranate juice or control drink for four weeks. Measurements were made at baseline and at four weeks. There was no effect of the intervention on PWV (P = 0.694) and plasma FRAP (P = 0.700). However, there was a significant fall in systolic blood pressure (-3.14 mmHg, P < 0.001), diastolic blood pressure (-2.33 mmHg P < 0.001) and mean arterial pressure (-2.60 mmHg, P < 0.001). Change in weight was similar in the two groups over the intervention period (P = 0.379). The fall in BP was not paralleled by changes in concentration of serum angiotensin converting enzyme. We conclude that pomegranate juice supplementation has benefits for BP in the short term, but has no effect on PWV. The mechanism for the effect is uncertain. SN - 1573-9104 UR - https://www.unboundmedicine.com/medline/citation/22648092/abstract/Effects_of_Pomegranate_Juice_Supplementation_on_Pulse_Wave_Velocity_and_Blood_Pressure_in_Healthy_Young_and_Middle_aged_Men_and_Women_ L2 - https://doi.org/10.1007/s11130-012-0295-z DB - PRIME DP - Unbound Medicine ER -