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Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants.
J Drugs Dermatol. 2012 Jun; 11(6):742-6.JD

Abstract

Acne vulgaris is a common dermatological condition characterized by hormonally-mediated sebum overproduction, follicular hyperkeratinization, and chronic inflammation of the pilosebaceous unit. Microbes, genetic susceptibilities, and various environmental factors have been linked to the pathogenesis of the condition. Over the last several years it has become apparent that patients with acne are under increased cutaneous and systemic oxidative stress. Moreover, the burden of oxidative stress may not be a mere consequence of acne; rather, the oxidative stress, lipid peroxidation in particular, may be an early event that helps to drive the acne process. Here, we explore the role of oxidative stress and review the preliminary research involving the administration of local and systemic antioxidants.

Authors+Show Affiliations

SUNY Downstate Medical Center, Department of Dermatolgy, Brooklyn, NY, USA. wpbowe@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22648222

Citation

Bowe, Whitney P., et al. "Acne Vulgaris: the Role of Oxidative Stress and the Potential Therapeutic Value of Local and Systemic Antioxidants." Journal of Drugs in Dermatology : JDD, vol. 11, no. 6, 2012, pp. 742-6.
Bowe WP, Patel N, Logan AC. Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. J Drugs Dermatol. 2012;11(6):742-6.
Bowe, W. P., Patel, N., & Logan, A. C. (2012). Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. Journal of Drugs in Dermatology : JDD, 11(6), 742-6.
Bowe WP, Patel N, Logan AC. Acne Vulgaris: the Role of Oxidative Stress and the Potential Therapeutic Value of Local and Systemic Antioxidants. J Drugs Dermatol. 2012;11(6):742-6. PubMed PMID: 22648222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. AU - Bowe,Whitney P, AU - Patel,Nayan, AU - Logan,Alan C, PY - 2012/6/1/entrez PY - 2012/6/1/pubmed PY - 2013/5/15/medline SP - 742 EP - 6 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 11 IS - 6 N2 - Acne vulgaris is a common dermatological condition characterized by hormonally-mediated sebum overproduction, follicular hyperkeratinization, and chronic inflammation of the pilosebaceous unit. Microbes, genetic susceptibilities, and various environmental factors have been linked to the pathogenesis of the condition. Over the last several years it has become apparent that patients with acne are under increased cutaneous and systemic oxidative stress. Moreover, the burden of oxidative stress may not be a mere consequence of acne; rather, the oxidative stress, lipid peroxidation in particular, may be an early event that helps to drive the acne process. Here, we explore the role of oxidative stress and review the preliminary research involving the administration of local and systemic antioxidants. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/22648222/Acne_vulgaris:_the_role_of_oxidative_stress_and_the_potential_therapeutic_value_of_local_and_systemic_antioxidants_ L2 - https://medlineplus.gov/acne.html DB - PRIME DP - Unbound Medicine ER -