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Vitamin K intake and status are low in hemodialysis patients.
Kidney Int. 2012 Sep; 82(5):605-10.KI

Abstract

Vitamin K is essential for the activity of γ-carboxyglutamate (Gla)-proteins including matrix Gla28 protein and osteocalcin; an inhibitor of vascular calcification and a bone matrix protein, respectively. Insufficient vitamin K intake leads to the production of non-carboxylated, inactive proteins and this could contribute to the high risk of vascular calcification in hemodialysis patients. To help resolve this, we measured vitamin K(1) and K(2) intake (4-day food record), and the vitamin K status in 40 hemodialysis patients. The intake was low in these patients (median 140 μg/day), especially on days of dialysis and the weekend as compared to intakes reported in a reference population of healthy adults (mean K(1) and K(2) intake 200 μg/day and 31 μg/day, respectively). Non-carboxylated bone and coagulation proteins were found to be elevated in 33 hemodialysis patients, indicating subclinical hepatic vitamin K deficiency. Additionally, very high non-carboxylated matrix Gla28 protein levels, endemic to all patients, suggest vascular vitamin K deficiency. Thus, compared to healthy individuals, hemodialysis patients have a poor overall vitamin K status due to low intake. A randomized controlled trial is needed to test whether vitamin K supplementation reduces the risk of arterial calcification and mortality in hemodialysis patients.

Authors+Show Affiliations

VitaK and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22648294

Citation

Cranenburg, Ellen C M., et al. "Vitamin K Intake and Status Are Low in Hemodialysis Patients." Kidney International, vol. 82, no. 5, 2012, pp. 605-10.
Cranenburg EC, Schurgers LJ, Uiterwijk HH, et al. Vitamin K intake and status are low in hemodialysis patients. Kidney Int. 2012;82(5):605-10.
Cranenburg, E. C., Schurgers, L. J., Uiterwijk, H. H., Beulens, J. W., Dalmeijer, G. W., Westerhuis, R., Magdeleyns, E. J., Herfs, M., Vermeer, C., & Laverman, G. D. (2012). Vitamin K intake and status are low in hemodialysis patients. Kidney International, 82(5), 605-10. https://doi.org/10.1038/ki.2012.191
Cranenburg EC, et al. Vitamin K Intake and Status Are Low in Hemodialysis Patients. Kidney Int. 2012;82(5):605-10. PubMed PMID: 22648294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin K intake and status are low in hemodialysis patients. AU - Cranenburg,Ellen C M, AU - Schurgers,Leon J, AU - Uiterwijk,Herma H, AU - Beulens,Joline W J, AU - Dalmeijer,Gerdien W, AU - Westerhuis,Ralf, AU - Magdeleyns,Elke J, AU - Herfs,Marjolein, AU - Vermeer,Cees, AU - Laverman,Gozewijn D, Y1 - 2012/05/30/ PY - 2012/6/1/entrez PY - 2012/6/1/pubmed PY - 2013/1/25/medline SP - 605 EP - 10 JF - Kidney international JO - Kidney Int VL - 82 IS - 5 N2 - Vitamin K is essential for the activity of γ-carboxyglutamate (Gla)-proteins including matrix Gla28 protein and osteocalcin; an inhibitor of vascular calcification and a bone matrix protein, respectively. Insufficient vitamin K intake leads to the production of non-carboxylated, inactive proteins and this could contribute to the high risk of vascular calcification in hemodialysis patients. To help resolve this, we measured vitamin K(1) and K(2) intake (4-day food record), and the vitamin K status in 40 hemodialysis patients. The intake was low in these patients (median 140 μg/day), especially on days of dialysis and the weekend as compared to intakes reported in a reference population of healthy adults (mean K(1) and K(2) intake 200 μg/day and 31 μg/day, respectively). Non-carboxylated bone and coagulation proteins were found to be elevated in 33 hemodialysis patients, indicating subclinical hepatic vitamin K deficiency. Additionally, very high non-carboxylated matrix Gla28 protein levels, endemic to all patients, suggest vascular vitamin K deficiency. Thus, compared to healthy individuals, hemodialysis patients have a poor overall vitamin K status due to low intake. A randomized controlled trial is needed to test whether vitamin K supplementation reduces the risk of arterial calcification and mortality in hemodialysis patients. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/22648294/Vitamin_K_intake_and_status_are_low_in_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)55598-1 DB - PRIME DP - Unbound Medicine ER -