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Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial.
Am J Clin Nutr. 2012 Jul; 96(1):5-13.AJ

Abstract

BACKGROUND

Acute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes. However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking.

OBJECTIVE

The primary aim of the study was to investigate the effects in subjects of alginate supplementation in conjunction with energy restriction (-300 kcal/d) on loss of body weight and fat and, second, on metabolic risk markers in comparison with in a placebo group.

DESIGN

In a parallel, double-blind, placebo-controlled study, we randomly assigned 96 obese subjects to either an energy-restricted diet plus a placebo preload supplement or an energy-restricted diet plus an alginate-based preload supplement (15 g fiber). The preload was administered as a beverage 3 times/d before main meals for a period of 12 wk.

RESULTS

No differences in loss of body weight and fat between groups were shown in the intension-to-treat (ITT) analysis (P > 0.1). However, in the completer analysis (n = 80), we showed a greater weight loss with alginate (6.78 ± 3.67 kg) than with the placebo (5.04 ± 3.40 kg) (P = 0.03), which was mainly attributed to a reduction in the percentage of body fat (P = 0.03). In the ITT analysis, a larger decrease in systolic and diastolic blood pressure was shown in the placebo group than in the alginate group (P < 0.05). Plasma concentrations of glucose, insulin, C-reactive protein, and ghrelin, HOMA-IR, and lipid metabolism did not differ between treatment groups in the ITT analysis (P > 0.1).

CONCLUSION

These results suggest that alginate supplementation as an adjunct to energy restriction may improve weight loss in obese subjects who complete a 12-wk dietary intervention.

Authors+Show Affiliations

Department of Human Nutrition, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. mmgj@life.ku.dkNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22648709

Citation

Georg Jensen, Morten, et al. "Effect of Alginate Supplementation On Weight Loss in Obese Subjects Completing a 12-wk Energy-restricted Diet: a Randomized Controlled Trial." The American Journal of Clinical Nutrition, vol. 96, no. 1, 2012, pp. 5-13.
Georg Jensen M, Kristensen M, Astrup A. Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial. Am J Clin Nutr. 2012;96(1):5-13.
Georg Jensen, M., Kristensen, M., & Astrup, A. (2012). Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial. The American Journal of Clinical Nutrition, 96(1), 5-13. https://doi.org/10.3945/ajcn.111.025312
Georg Jensen M, Kristensen M, Astrup A. Effect of Alginate Supplementation On Weight Loss in Obese Subjects Completing a 12-wk Energy-restricted Diet: a Randomized Controlled Trial. Am J Clin Nutr. 2012;96(1):5-13. PubMed PMID: 22648709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial. AU - Georg Jensen,Morten, AU - Kristensen,Mette, AU - Astrup,Arne, Y1 - 2012/05/30/ PY - 2012/6/1/entrez PY - 2012/6/1/pubmed PY - 2012/9/8/medline SP - 5 EP - 13 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 96 IS - 1 N2 - BACKGROUND: Acute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes. However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking. OBJECTIVE: The primary aim of the study was to investigate the effects in subjects of alginate supplementation in conjunction with energy restriction (-300 kcal/d) on loss of body weight and fat and, second, on metabolic risk markers in comparison with in a placebo group. DESIGN: In a parallel, double-blind, placebo-controlled study, we randomly assigned 96 obese subjects to either an energy-restricted diet plus a placebo preload supplement or an energy-restricted diet plus an alginate-based preload supplement (15 g fiber). The preload was administered as a beverage 3 times/d before main meals for a period of 12 wk. RESULTS: No differences in loss of body weight and fat between groups were shown in the intension-to-treat (ITT) analysis (P > 0.1). However, in the completer analysis (n = 80), we showed a greater weight loss with alginate (6.78 ± 3.67 kg) than with the placebo (5.04 ± 3.40 kg) (P = 0.03), which was mainly attributed to a reduction in the percentage of body fat (P = 0.03). In the ITT analysis, a larger decrease in systolic and diastolic blood pressure was shown in the placebo group than in the alginate group (P < 0.05). Plasma concentrations of glucose, insulin, C-reactive protein, and ghrelin, HOMA-IR, and lipid metabolism did not differ between treatment groups in the ITT analysis (P > 0.1). CONCLUSION: These results suggest that alginate supplementation as an adjunct to energy restriction may improve weight loss in obese subjects who complete a 12-wk dietary intervention. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22648709/Effect_of_alginate_supplementation_on_weight_loss_in_obese_subjects_completing_a_12_wk_energy_restricted_diet:_a_randomized_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -