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Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia.
BMC Infect Dis. 2012 May 31; 12:126.BI

Abstract

BACKGROUND

Although the prevalence of macrolide-resistant Mycoplasma pneumoniae isolates in Japanese pediatric patients has increased rapidly, there have been no reports concerning macrolide-resistant M. pneumoniae infection in adolescents aged 16 to 19 years old. The purpose of this study was to clarify the prevalence and clinical characteristics of macrolide-resistant M. pneumoniae in adolescent patients with community-acquired pneumonia.

METHODS

A total of 99 cases with M. pneumoniae pneumonia confirmed by polymerase chain reaction (PCR) and culture were analyzed. Forty-five cases were pediatric patients less than 16 years old, 26 cases were 16 to 19-year-old adolescent patients and 28 cases were adult patients. Primers for domain V of 23S rRNA were used and DNA sequences of the PCR products were compared with the sequence of an M. pneumoniae reference strain.

RESULTS

Thirty of 45 pediatric patients (66%), 12 of 26 adolescent patients (46%) and seven of 28 adult patients (25%) with M. pneumoniae pneumonia were found to be infected with macrolide-resistant M. pneumoniae (MR patients). Although the prevalence of resistant strains was similar in pediatric patients between 2008 and 2011, an increase in the prevalence of resistant strains was observed in adolescent patients. Among 30 pediatric MR patients, 26 had an A-to-G transition at position 2063 (A2063G) and four had an A-to-G transition at position 2064 (A2064G). In 12 adolescent MR patients, 10 showed an A2063G transition and two showed an A2064G transition, and in seven adult MR patients, six showed an A2063G transition and one showed an A2064G transition.

CONCLUSIONS

The prevalence of macrolide-resistant M. pneumoniae is high among adolescent patients as well as pediatric patients less than 16-years old. To prevent outbreaks of M. pneumoniae infection, especially macrolide-resistant M. pneumoniae, in closed populations including among families, in schools and in university students, physicians should pay close attention to macrolide-resistant M. pneumoniae.

Authors+Show Affiliations

Department of Internal Medicine , Kawasaki Medical School, Okayama, Japan. nao@med.kawasaki-m.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22650321

Citation

Miyashita, Naoyuki, et al. "Macrolide-resistant Mycoplasma Pneumoniae in Adolescents With Community-acquired Pneumonia." BMC Infectious Diseases, vol. 12, 2012, p. 126.
Miyashita N, Kawai Y, Akaike H, et al. Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia. BMC Infect Dis. 2012;12:126.
Miyashita, N., Kawai, Y., Akaike, H., Ouchi, K., Hayashi, T., Kurihara, T., & Okimoto, N. (2012). Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia. BMC Infectious Diseases, 12, 126. https://doi.org/10.1186/1471-2334-12-126
Miyashita N, et al. Macrolide-resistant Mycoplasma Pneumoniae in Adolescents With Community-acquired Pneumonia. BMC Infect Dis. 2012 May 31;12:126. PubMed PMID: 22650321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia. AU - Miyashita,Naoyuki, AU - Kawai,Yasuhiro, AU - Akaike,Hiroto, AU - Ouchi,Kazunobu, AU - Hayashi,Toshikiyo, AU - Kurihara,Takeyuki, AU - Okimoto,Niro, AU - ,, Y1 - 2012/05/31/ PY - 2011/12/19/received PY - 2012/05/31/accepted PY - 2012/6/2/entrez PY - 2012/6/2/pubmed PY - 2013/2/23/medline SP - 126 EP - 126 JF - BMC infectious diseases JO - BMC Infect Dis VL - 12 N2 - BACKGROUND: Although the prevalence of macrolide-resistant Mycoplasma pneumoniae isolates in Japanese pediatric patients has increased rapidly, there have been no reports concerning macrolide-resistant M. pneumoniae infection in adolescents aged 16 to 19 years old. The purpose of this study was to clarify the prevalence and clinical characteristics of macrolide-resistant M. pneumoniae in adolescent patients with community-acquired pneumonia. METHODS: A total of 99 cases with M. pneumoniae pneumonia confirmed by polymerase chain reaction (PCR) and culture were analyzed. Forty-five cases were pediatric patients less than 16 years old, 26 cases were 16 to 19-year-old adolescent patients and 28 cases were adult patients. Primers for domain V of 23S rRNA were used and DNA sequences of the PCR products were compared with the sequence of an M. pneumoniae reference strain. RESULTS: Thirty of 45 pediatric patients (66%), 12 of 26 adolescent patients (46%) and seven of 28 adult patients (25%) with M. pneumoniae pneumonia were found to be infected with macrolide-resistant M. pneumoniae (MR patients). Although the prevalence of resistant strains was similar in pediatric patients between 2008 and 2011, an increase in the prevalence of resistant strains was observed in adolescent patients. Among 30 pediatric MR patients, 26 had an A-to-G transition at position 2063 (A2063G) and four had an A-to-G transition at position 2064 (A2064G). In 12 adolescent MR patients, 10 showed an A2063G transition and two showed an A2064G transition, and in seven adult MR patients, six showed an A2063G transition and one showed an A2064G transition. CONCLUSIONS: The prevalence of macrolide-resistant M. pneumoniae is high among adolescent patients as well as pediatric patients less than 16-years old. To prevent outbreaks of M. pneumoniae infection, especially macrolide-resistant M. pneumoniae, in closed populations including among families, in schools and in university students, physicians should pay close attention to macrolide-resistant M. pneumoniae. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/22650321/Macrolide_resistant_Mycoplasma_pneumoniae_in_adolescents_with_community_acquired_pneumonia_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-12-126 DB - PRIME DP - Unbound Medicine ER -