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An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites.
Biosens Bioelectron. 2012 Oct-Dec; 38(1):100-6.BB

Abstract

We constructed a highly responsive ascorbic acid (AA) sensor utilizing over-oxidized polypyrrole (OPPy) and Palladium nanoparticles (PdNPs) composites (OPPy-PdNPs). In the presence of PdNPs, polypyrrole (PPy) was coated on a gold (Au) electrode through cyclic voltammetry (CV) and over-oxidized at a fixed potential in NaOH solution. The PdNPs were characterized using ultraviolet-visible (UV-vis) spectrum and transmission electron microscopy (TEM). The surface of OPPy-PdNPs on the Au electrode was investigated using field-emission scanning electron microscopy (FE-SEM). Results revealed that the OPPy-PdNPs-modified Au electrode (OPPy-PdNPs/Au) has the capacity to catalyze the oxidation of AA by lowering its oxidation potential to 0 V. The OPPy-PdNPs/Au electrode exhibited 2 different linear concentration ranges. In the low concentration range (1-520 μM), OPPy-PdNPs/Au exhibited a direct linear relation with current responses and had high sensitivity (570 μA mM(-1)cm(-2)) and a high correlation coefficient (0.995). In contrast, in the higher concentration range (120-1600 μM), the relationship between current responses and concentration of AA can be represented by a two-parameter sigmoidal equation. In addition, the sensor exhibited a short response time (less than 2s) and a very low limit of detection of 1 μM. The electrochemical AA sensor constructed in this study was simple, inexpensive, reproducible, sensitive, and resistant to interference. Thus, the proposed sensor has great potential for detecting AA in complex biosystems and can be applied in various fields, particularly neuroscience.

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Authors+Show Affiliations

Shi W
State Key Laboratory of Transducer, Institute of Electronics, Chinese Academy of Science, Beijing 100190, PR China.
Liu C
No affiliation info available
Song Y
No affiliation info available
Lin N
No affiliation info available
Zhou S
No affiliation info available
Cai X
No affiliation info available

MeSH

Ascorbic AcidBiosensing TechniquesElectrochemical TechniquesElectrodesGoldLimit of DetectionNanoparticlesOxidation-ReductionPalladiumPolymersPyrroles

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22651968

Citation

Shi, Wentao, et al. "An Ascorbic Acid Amperometric Sensor Using Over-oxidized Polypyrrole and Palladium Nanoparticles Composites." Biosensors & Bioelectronics, vol. 38, no. 1, 2012, pp. 100-6.
Shi W, Liu C, Song Y, et al. An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites. Biosens Bioelectron. 2012;38(1):100-6.
Shi, W., Liu, C., Song, Y., Lin, N., Zhou, S., & Cai, X. (2012). An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites. Biosensors & Bioelectronics, 38(1), 100-6. https://doi.org/10.1016/j.bios.2012.05.004
Shi W, et al. An Ascorbic Acid Amperometric Sensor Using Over-oxidized Polypyrrole and Palladium Nanoparticles Composites. Biosens Bioelectron. 2012 Oct-Dec;38(1):100-6. PubMed PMID: 22651968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites. AU - Shi,Wentao, AU - Liu,Chunxiu, AU - Song,Yilin, AU - Lin,Nansen, AU - Zhou,Shuai, AU - Cai,Xinxia, Y1 - 2012/05/16/ PY - 2012/02/13/received PY - 2012/04/27/revised PY - 2012/05/07/accepted PY - 2012/6/2/entrez PY - 2012/6/2/pubmed PY - 2012/12/12/medline SP - 100 EP - 6 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 38 IS - 1 N2 - We constructed a highly responsive ascorbic acid (AA) sensor utilizing over-oxidized polypyrrole (OPPy) and Palladium nanoparticles (PdNPs) composites (OPPy-PdNPs). In the presence of PdNPs, polypyrrole (PPy) was coated on a gold (Au) electrode through cyclic voltammetry (CV) and over-oxidized at a fixed potential in NaOH solution. The PdNPs were characterized using ultraviolet-visible (UV-vis) spectrum and transmission electron microscopy (TEM). The surface of OPPy-PdNPs on the Au electrode was investigated using field-emission scanning electron microscopy (FE-SEM). Results revealed that the OPPy-PdNPs-modified Au electrode (OPPy-PdNPs/Au) has the capacity to catalyze the oxidation of AA by lowering its oxidation potential to 0 V. The OPPy-PdNPs/Au electrode exhibited 2 different linear concentration ranges. In the low concentration range (1-520 μM), OPPy-PdNPs/Au exhibited a direct linear relation with current responses and had high sensitivity (570 μA mM(-1)cm(-2)) and a high correlation coefficient (0.995). In contrast, in the higher concentration range (120-1600 μM), the relationship between current responses and concentration of AA can be represented by a two-parameter sigmoidal equation. In addition, the sensor exhibited a short response time (less than 2s) and a very low limit of detection of 1 μM. The electrochemical AA sensor constructed in this study was simple, inexpensive, reproducible, sensitive, and resistant to interference. Thus, the proposed sensor has great potential for detecting AA in complex biosystems and can be applied in various fields, particularly neuroscience. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/22651968/An_ascorbic_acid_amperometric_sensor_using_over_oxidized_polypyrrole_and_palladium_nanoparticles_composites_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(12)00284-9 DB - PRIME DP - Unbound Medicine ER -