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Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides.
Int J Biol Macromol. 2012 Nov; 51(4):412-6.IJ

Abstract

Diverse classes of sulfated polysaccharides obtained from the red seaweeds (Rhodophyta) Grateloupia indica, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatum and Cystoseira indica and the green seaweed (Chlorophyta) Caulerpa racemosa were assayed for antiviral activity against the four serotypes of dengue virus (DENV). DENV-2 was the most susceptible serotype to all polysulfates, with inhibitory concentration 50% values in the range 0.12-20 μg/mL. The antiviral potency of the sulfated polysaccharides depended on the sulfate content, the position of sulfate group, the sugar composition, and the molar mass. Independently of the sugar composition, the antiviral effect was mainly exerted during DENV-2 adsorption and internalization.

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Authors+Show Affiliations

Pujol CA
Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Piso 4, 1428 Buenos Aires, Argentina.
Ray S
No affiliation info available
Ray B
No affiliation info available
Damonte EB
No affiliation info available

MeSH

AnimalsAntiviral AgentsChlorocebus aethiopsChlorophytaDengue VirusPhaeophytaPolysaccharidesRhodophytaSulfatesVero Cells

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22652218

Citation

Pujol, Carlos A., et al. "Antiviral Activity Against Dengue Virus of Diverse Classes of Algal Sulfated Polysaccharides." International Journal of Biological Macromolecules, vol. 51, no. 4, 2012, pp. 412-6.
Pujol CA, Ray S, Ray B, et al. Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides. Int J Biol Macromol. 2012;51(4):412-6.
Pujol, C. A., Ray, S., Ray, B., & Damonte, E. B. (2012). Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides. International Journal of Biological Macromolecules, 51(4), 412-6. https://doi.org/10.1016/j.ijbiomac.2012.05.028
Pujol CA, et al. Antiviral Activity Against Dengue Virus of Diverse Classes of Algal Sulfated Polysaccharides. Int J Biol Macromol. 2012;51(4):412-6. PubMed PMID: 22652218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides. AU - Pujol,Carlos A, AU - Ray,Sayani, AU - Ray,Bimalendu, AU - Damonte,Elsa B, Y1 - 2012/05/28/ PY - 2012/04/20/received PY - 2012/05/17/revised PY - 2012/05/18/accepted PY - 2012/6/2/entrez PY - 2012/6/2/pubmed PY - 2013/1/15/medline SP - 412 EP - 6 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 51 IS - 4 N2 - Diverse classes of sulfated polysaccharides obtained from the red seaweeds (Rhodophyta) Grateloupia indica, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatum and Cystoseira indica and the green seaweed (Chlorophyta) Caulerpa racemosa were assayed for antiviral activity against the four serotypes of dengue virus (DENV). DENV-2 was the most susceptible serotype to all polysulfates, with inhibitory concentration 50% values in the range 0.12-20 μg/mL. The antiviral potency of the sulfated polysaccharides depended on the sulfate content, the position of sulfate group, the sugar composition, and the molar mass. Independently of the sugar composition, the antiviral effect was mainly exerted during DENV-2 adsorption and internalization. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/22652218/Antiviral_activity_against_dengue_virus_of_diverse_classes_of_algal_sulfated_polysaccharides_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(12)00199-7 DB - PRIME DP - Unbound Medicine ER -