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Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality.
Clin Nutr 2012; 31(4):448-54CN

Abstract

BACKGROUND & AIMS

Results from randomized controlled trials (RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were inconclusive. The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT.

METHODS

RCT publications on the effect of B vitamin supplementation on plasma Hcy, cardiovascular and all-cause mortality were searched from PubMed and web of science database. Data were independently abstracted by 2 investigators using a standardized protocol. The results were pooled with a fixed-effects model using Stata software.

RESULTS

Data from 19 studies including 47921 participants were analyzed using a fixed-effects model. The overall relative risks with 95% confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94-1.03) for CVD, 0.98 (0.92-1.05) for coronary heart disease (CHD), 0.97 (0.90-1.05) for myocardial infarction (MI), 0.88 (0.82-0.95) for stroke, and 0.97 (0.91-1.02) for cardiovascular death, 0.99 (0.95-1.04) for all-cause mortality. Blood Hcy levels were decreased in all included RCTs.

CONCLUSIONS

B vitamin supplementation has a significant protective effect on stroke, but none on the risk of CVD, MI, CHD, cardiovascular death, or all-cause mortality.

Authors+Show Affiliations

Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, PR China. taohuang83@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22652362

Citation

Huang, Tao, et al. "Meta-analysis of B Vitamin Supplementation On Plasma Homocysteine, Cardiovascular and All-cause Mortality." Clinical Nutrition (Edinburgh, Scotland), vol. 31, no. 4, 2012, pp. 448-54.
Huang T, Chen Y, Yang B, et al. Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. Clin Nutr. 2012;31(4):448-54.
Huang, T., Chen, Y., Yang, B., Yang, J., Wahlqvist, M. L., & Li, D. (2012). Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. Clinical Nutrition (Edinburgh, Scotland), 31(4), pp. 448-54. doi:10.1016/j.clnu.2011.01.003.
Huang T, et al. Meta-analysis of B Vitamin Supplementation On Plasma Homocysteine, Cardiovascular and All-cause Mortality. Clin Nutr. 2012;31(4):448-54. PubMed PMID: 22652362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. AU - Huang,Tao, AU - Chen,Ying, AU - Yang,Bin, AU - Yang,Jing, AU - Wahlqvist,Mark L, AU - Li,Duo, Y1 - 2012/05/29/ PY - 2010/09/16/received PY - 2010/12/26/revised PY - 2011/01/04/accepted PY - 2012/6/2/entrez PY - 2012/6/2/pubmed PY - 2012/12/10/medline SP - 448 EP - 54 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 31 IS - 4 N2 - BACKGROUND & AIMS: Results from randomized controlled trials (RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were inconclusive. The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT. METHODS: RCT publications on the effect of B vitamin supplementation on plasma Hcy, cardiovascular and all-cause mortality were searched from PubMed and web of science database. Data were independently abstracted by 2 investigators using a standardized protocol. The results were pooled with a fixed-effects model using Stata software. RESULTS: Data from 19 studies including 47921 participants were analyzed using a fixed-effects model. The overall relative risks with 95% confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94-1.03) for CVD, 0.98 (0.92-1.05) for coronary heart disease (CHD), 0.97 (0.90-1.05) for myocardial infarction (MI), 0.88 (0.82-0.95) for stroke, and 0.97 (0.91-1.02) for cardiovascular death, 0.99 (0.95-1.04) for all-cause mortality. Blood Hcy levels were decreased in all included RCTs. CONCLUSIONS: B vitamin supplementation has a significant protective effect on stroke, but none on the risk of CVD, MI, CHD, cardiovascular death, or all-cause mortality. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/22652362/Meta_analysis_of_B_vitamin_supplementation_on_plasma_homocysteine_cardiovascular_and_all_cause_mortality_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(11)00005-7 DB - PRIME DP - Unbound Medicine ER -