Tags

Type your tag names separated by a space and hit enter

Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
World J Gastroenterol 2012; 18(19):2300-8WJ

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma. NAFLD is regarded as a hepatic manifestation of metabolic syndrome and incidence has been increasing worldwide in line with the increased prevalence of obesity, type 2 diabetes, and hyperlipemia. Animal models of NAFLD/NASH give crucial information, not only in elucidating pathogenesis of NAFLD/NASH but also in examining therapeutic effects of various agents. An ideal model of NAFLD/NASH should correctly reflect both hepatic histopathology and pathophysiology of human NAFLD/NASH. Animal models of NAFLD/NASH are divided into genetic, dietary, and combination models. In this paper, we review commonly used animal models of NAFLD/NASH referring to their advantages and disadvantages.

Authors+Show Affiliations

Department of Pathology, Teikyo University School of Medicine, Tokyo 173-8605, Japan. ytakaha-tky@umin.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Editorial
Review

Language

eng

PubMed ID

22654421

Citation

Takahashi, Yoshihisa, et al. "Animal Models of Nonalcoholic Fatty Liver Disease/nonalcoholic Steatohepatitis." World Journal of Gastroenterology, vol. 18, no. 19, 2012, pp. 2300-8.
Takahashi Y, Soejima Y, Fukusato T. Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol. 2012;18(19):2300-8.
Takahashi, Y., Soejima, Y., & Fukusato, T. (2012). Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World Journal of Gastroenterology, 18(19), pp. 2300-8. doi:10.3748/wjg.v18.i19.2300.
Takahashi Y, Soejima Y, Fukusato T. Animal Models of Nonalcoholic Fatty Liver Disease/nonalcoholic Steatohepatitis. World J Gastroenterol. 2012 May 21;18(19):2300-8. PubMed PMID: 22654421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. AU - Takahashi,Yoshihisa, AU - Soejima,Yurie, AU - Fukusato,Toshio, PY - 2011/10/11/received PY - 2012/02/20/revised PY - 2012/02/26/accepted PY - 2012/6/2/entrez PY - 2012/6/2/pubmed PY - 2012/10/17/medline KW - Animal model KW - Histopathology KW - Metabolic syndrome KW - Nonalcoholic fatty liver disease KW - Nonalcoholic steatohepatitis SP - 2300 EP - 8 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 18 IS - 19 N2 - Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma. NAFLD is regarded as a hepatic manifestation of metabolic syndrome and incidence has been increasing worldwide in line with the increased prevalence of obesity, type 2 diabetes, and hyperlipemia. Animal models of NAFLD/NASH give crucial information, not only in elucidating pathogenesis of NAFLD/NASH but also in examining therapeutic effects of various agents. An ideal model of NAFLD/NASH should correctly reflect both hepatic histopathology and pathophysiology of human NAFLD/NASH. Animal models of NAFLD/NASH are divided into genetic, dietary, and combination models. In this paper, we review commonly used animal models of NAFLD/NASH referring to their advantages and disadvantages. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/22654421/Animal_models_of_nonalcoholic_fatty_liver_disease/nonalcoholic_steatohepatitis_ L2 - http://www.wjgnet.com/1007-9327/full/v18/i19/2300.htm DB - PRIME DP - Unbound Medicine ER -