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Serum 25-hydroxyvitamin D concentration and mortality from heart failure and cardiovascular disease, and premature mortality from all-cause in United States adults.
Am J Cardiol. 2012 Sep 15; 110(6):834-9.AJ

Abstract

We aimed to examine associations between serum 25-hydroxyvitamin D (25[OH]D) concentration and mortality from heart failure (HF) and cardiovascular disease (CVD) and premature death from all causes using data from the Third National Health and Nutrition Examination Survey, which included 13,131 participants (6,130 men, 7,001 women) ≥35 years old at baseline (1988 to 1994) and followed through December 2000. Premature death was defined all-cause death at <75 years of age. Results indicated that during an average 8-year follow-up, there were 3,266 deaths (24.9%) including 101 deaths from HF, 1,451 from CVD, and 1,066 premature all-cause deaths. Among HF deaths, 37% of decedents had serum 25(OH)D levels <20 ng/ml, whereas only 26% of those with non-HF deaths had such levels (p <0.001). Multivariate-adjusted Cox model indicated that subjects with serum 25(OH)D levels <20 ng/ml had 2.06 times higher risk (95% confidence interval 1.01 to 4.25) of HF death than those with serum 25(OH)D levels ≥30 ng/ml (p <0.001). In addition, hazard ratios (95% confidence intervals) for premature death from all causes were 1.40 (1.17 to 1.68) in subjects with serum 25(OH)D levels <20 ng/ml and 1.11 (0.93 to 1.33) in those with serum 25(OH)D levels of 20 to 29 ng/ml compared to those with serum 25(OH)D levels ≥30 ng/ml (p <0.001, test for trend). In conclusion, adults with inadequate serum 25(OH)D levels have significantly higher risk of death from HF and all CVDs and all-cause premature death.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA, USA. Longjian.Liu@Drexel.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22658246

Citation

Liu, Longjian, et al. "Serum 25-hydroxyvitamin D Concentration and Mortality From Heart Failure and Cardiovascular Disease, and Premature Mortality From All-cause in United States Adults." The American Journal of Cardiology, vol. 110, no. 6, 2012, pp. 834-9.
Liu L, Chen M, Hankins SR, et al. Serum 25-hydroxyvitamin D concentration and mortality from heart failure and cardiovascular disease, and premature mortality from all-cause in United States adults. Am J Cardiol. 2012;110(6):834-9.
Liu, L., Chen, M., Hankins, S. R., Nùñez, A. E., Watson, R. A., Weinstock, P. J., Newschaffer, C. J., & Eisen, H. J. (2012). Serum 25-hydroxyvitamin D concentration and mortality from heart failure and cardiovascular disease, and premature mortality from all-cause in United States adults. The American Journal of Cardiology, 110(6), 834-9. https://doi.org/10.1016/j.amjcard.2012.05.013
Liu L, et al. Serum 25-hydroxyvitamin D Concentration and Mortality From Heart Failure and Cardiovascular Disease, and Premature Mortality From All-cause in United States Adults. Am J Cardiol. 2012 Sep 15;110(6):834-9. PubMed PMID: 22658246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D concentration and mortality from heart failure and cardiovascular disease, and premature mortality from all-cause in United States adults. AU - Liu,Longjian, AU - Chen,Ming, AU - Hankins,Shelley R, AU - Nùñez,Ana E, AU - Watson,Robert A, AU - Weinstock,Perry J, AU - Newschaffer,Craig J, AU - Eisen,Howard J, AU - ,, Y1 - 2012/06/02/ PY - 2012/03/08/received PY - 2012/05/08/revised PY - 2012/05/08/accepted PY - 2012/6/5/entrez PY - 2012/6/5/pubmed PY - 2013/4/13/medline SP - 834 EP - 9 JF - The American journal of cardiology JO - Am J Cardiol VL - 110 IS - 6 N2 - We aimed to examine associations between serum 25-hydroxyvitamin D (25[OH]D) concentration and mortality from heart failure (HF) and cardiovascular disease (CVD) and premature death from all causes using data from the Third National Health and Nutrition Examination Survey, which included 13,131 participants (6,130 men, 7,001 women) ≥35 years old at baseline (1988 to 1994) and followed through December 2000. Premature death was defined all-cause death at <75 years of age. Results indicated that during an average 8-year follow-up, there were 3,266 deaths (24.9%) including 101 deaths from HF, 1,451 from CVD, and 1,066 premature all-cause deaths. Among HF deaths, 37% of decedents had serum 25(OH)D levels <20 ng/ml, whereas only 26% of those with non-HF deaths had such levels (p <0.001). Multivariate-adjusted Cox model indicated that subjects with serum 25(OH)D levels <20 ng/ml had 2.06 times higher risk (95% confidence interval 1.01 to 4.25) of HF death than those with serum 25(OH)D levels ≥30 ng/ml (p <0.001). In addition, hazard ratios (95% confidence intervals) for premature death from all causes were 1.40 (1.17 to 1.68) in subjects with serum 25(OH)D levels <20 ng/ml and 1.11 (0.93 to 1.33) in those with serum 25(OH)D levels of 20 to 29 ng/ml compared to those with serum 25(OH)D levels ≥30 ng/ml (p <0.001, test for trend). In conclusion, adults with inadequate serum 25(OH)D levels have significantly higher risk of death from HF and all CVDs and all-cause premature death. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/22658246/Serum_25_hydroxyvitamin_D_concentration_and_mortality_from_heart_failure_and_cardiovascular_disease_and_premature_mortality_from_all_cause_in_United_States_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(12)01343-4 DB - PRIME DP - Unbound Medicine ER -