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Mesenchymal stem cell sheet encapsulated cartilage debris provides great potential for cartilage defects repair in osteoarthritis.
Med Hypotheses. 2012 Sep; 79(3):420-1.MH

Abstract

The restoration of the degenerated articular cartilage in patients with osteoarthritis (OA) is still a challenge for researchers and clinicians. Drug interventions and surgical treatments have been widely attempted for cartilage regeneration in OA. However, the results were largely unsatisfactory. Autologous chondrocyte implantation (ACI) or matrix-induced autologous chondrocyte implantation (MACI) offers potential for the regeneration of cartilage over the long-term. However, due to the limitations and disadvantages of ACI, alternative therapies for cartilage regeneration are in need. The availability of large quantities of mesenchymal stem cells (MSCs) and the multilineage differentiation, especially their chondrogenic differentiation property, have made MSCs the most promising cell source for cartilage regeneration. In addition, MSCs have been shown the ability to undergo site-specific differentiation. MSCs can be obtained as MSC sheets using the temperature-responsive culture dish method. The MSC sheet can provide amounts of cells and extracellular matrix, which might provide the continuity between the implant and host cartilage, thus improving integrative cartilage repair. Moreover, OA is associated with progressive and often severe inflammation. MSCs not only have the ability to contribute structurally to tissue repair, but also possess potent immunomodulatory and anti-inflammatory effects. Taken together, these properties make MSC sheet promising candidate for cartilage repair in OA. We hypothesize that MSC sheet encapsulated cartilage debris can efficiently promote cartilage repair in OA patients. Chondrocytes can be obtained and cultured from small cartilage debris in vitro. Therefore, the chondrocytes may grow from the debris in cartilage defect and improve cartilage regeneration. MSC sheet provide amounts of cells, ECM and protein for cartilage regeneration and integration, and may play some roles of periosteum. The operation of MSC sheet encapsulated cartilage debris for cartilage repair is simple and practical. Moreover, the cell sheet/cartilage debris constructs can be easily shaped based on the size and shape of cartilage defects. The new method might have great potential in treating cartilage defects clinically, especially for OA patients.

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Authors

Qi Y
No affiliation info available
Yan W
No affiliation info available

MeSH

Cartilage, ArticularHumansMesenchymal Stem CellsOsteoarthritis

Pub Type(s)

Letter
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22658361

Citation

Qi, Yiying, and Weiqi Yan. "Mesenchymal Stem Cell Sheet Encapsulated Cartilage Debris Provides Great Potential for Cartilage Defects Repair in Osteoarthritis." Medical Hypotheses, vol. 79, no. 3, 2012, pp. 420-1.
Qi Y, Yan W. Mesenchymal stem cell sheet encapsulated cartilage debris provides great potential for cartilage defects repair in osteoarthritis. Med Hypotheses. 2012;79(3):420-1.
Qi, Y., & Yan, W. (2012). Mesenchymal stem cell sheet encapsulated cartilage debris provides great potential for cartilage defects repair in osteoarthritis. Medical Hypotheses, 79(3), 420-1. https://doi.org/10.1016/j.mehy.2012.05.024
Qi Y, Yan W. Mesenchymal Stem Cell Sheet Encapsulated Cartilage Debris Provides Great Potential for Cartilage Defects Repair in Osteoarthritis. Med Hypotheses. 2012;79(3):420-1. PubMed PMID: 22658361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesenchymal stem cell sheet encapsulated cartilage debris provides great potential for cartilage defects repair in osteoarthritis. AU - Qi,Yiying, AU - Yan,Weiqi, Y1 - 2012/06/01/ PY - 2012/03/14/received PY - 2012/05/13/accepted PY - 2012/6/5/entrez PY - 2012/6/5/pubmed PY - 2012/12/13/medline SP - 420 EP - 1 JF - Medical hypotheses JO - Med Hypotheses VL - 79 IS - 3 N2 - The restoration of the degenerated articular cartilage in patients with osteoarthritis (OA) is still a challenge for researchers and clinicians. Drug interventions and surgical treatments have been widely attempted for cartilage regeneration in OA. However, the results were largely unsatisfactory. Autologous chondrocyte implantation (ACI) or matrix-induced autologous chondrocyte implantation (MACI) offers potential for the regeneration of cartilage over the long-term. However, due to the limitations and disadvantages of ACI, alternative therapies for cartilage regeneration are in need. The availability of large quantities of mesenchymal stem cells (MSCs) and the multilineage differentiation, especially their chondrogenic differentiation property, have made MSCs the most promising cell source for cartilage regeneration. In addition, MSCs have been shown the ability to undergo site-specific differentiation. MSCs can be obtained as MSC sheets using the temperature-responsive culture dish method. The MSC sheet can provide amounts of cells and extracellular matrix, which might provide the continuity between the implant and host cartilage, thus improving integrative cartilage repair. Moreover, OA is associated with progressive and often severe inflammation. MSCs not only have the ability to contribute structurally to tissue repair, but also possess potent immunomodulatory and anti-inflammatory effects. Taken together, these properties make MSC sheet promising candidate for cartilage repair in OA. We hypothesize that MSC sheet encapsulated cartilage debris can efficiently promote cartilage repair in OA patients. Chondrocytes can be obtained and cultured from small cartilage debris in vitro. Therefore, the chondrocytes may grow from the debris in cartilage defect and improve cartilage regeneration. MSC sheet provide amounts of cells, ECM and protein for cartilage regeneration and integration, and may play some roles of periosteum. The operation of MSC sheet encapsulated cartilage debris for cartilage repair is simple and practical. Moreover, the cell sheet/cartilage debris constructs can be easily shaped based on the size and shape of cartilage defects. The new method might have great potential in treating cartilage defects clinically, especially for OA patients. SN - 1532-2777 UR - https://www.unboundmedicine.com/medline/citation/22658361/Mesenchymal_stem_cell_sheet_encapsulated_cartilage_debris_provides_great_potential_for_cartilage_defects_repair_in_osteoarthritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(12)00247-2 DB - PRIME DP - Unbound Medicine ER -