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A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaeli Debx. with potential analgesic activity and less toxicity.
Bioorg Med Chem Lett. 2012 Jul 01; 22(13):4444-6.BM

Abstract

Further investigation on the phytochemistry of the plant Aconitum carmichaeli Debx. led to isolate a new franchetine type C(19)-diterpenoid alkaloid, guiwuline 1. Its structure was established on the basis of the spectroscopic data (1D and 2D NMR, HRESIMS, UV, IR). In mouse hot-plate test and acute toxicity assay, compound 1 exhibited potential analgesic activity (ED(50), 15 mg/kg) and showed little toxicity to mice (LD(50), 500 mg/kg). The results indicate that compound 1 may be used as a lead molecule to develop novel analgesic agents.

Authors+Show Affiliations

The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22658863

Citation

Wang, Dao-Ping, et al. "A Novel Franchetine Type Norditerpenoid Isolated From the Roots of Aconitum Carmichaeli Debx. With Potential Analgesic Activity and Less Toxicity." Bioorganic & Medicinal Chemistry Letters, vol. 22, no. 13, 2012, pp. 4444-6.
Wang DP, Lou HY, Huang L, et al. A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaeli Debx. with potential analgesic activity and less toxicity. Bioorg Med Chem Lett. 2012;22(13):4444-6.
Wang, D. P., Lou, H. Y., Huang, L., Hao, X. J., Liang, G. Y., Yang, Z. C., & Pan, W. D. (2012). A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaeli Debx. with potential analgesic activity and less toxicity. Bioorganic & Medicinal Chemistry Letters, 22(13), 4444-6. https://doi.org/10.1016/j.bmcl.2012.04.132
Wang DP, et al. A Novel Franchetine Type Norditerpenoid Isolated From the Roots of Aconitum Carmichaeli Debx. With Potential Analgesic Activity and Less Toxicity. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4444-6. PubMed PMID: 22658863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaeli Debx. with potential analgesic activity and less toxicity. AU - Wang,Dao-Ping, AU - Lou,Hua-Yong, AU - Huang,Lan, AU - Hao,Xiao-Jiang, AU - Liang,Guang-Yi, AU - Yang,Zai-Chang, AU - Pan,Wei-Dong, Y1 - 2012/05/14/ PY - 2012/02/16/received PY - 2012/04/07/revised PY - 2012/04/18/accepted PY - 2012/6/5/entrez PY - 2012/6/5/pubmed PY - 2012/10/20/medline SP - 4444 EP - 6 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 22 IS - 13 N2 - Further investigation on the phytochemistry of the plant Aconitum carmichaeli Debx. led to isolate a new franchetine type C(19)-diterpenoid alkaloid, guiwuline 1. Its structure was established on the basis of the spectroscopic data (1D and 2D NMR, HRESIMS, UV, IR). In mouse hot-plate test and acute toxicity assay, compound 1 exhibited potential analgesic activity (ED(50), 15 mg/kg) and showed little toxicity to mice (LD(50), 500 mg/kg). The results indicate that compound 1 may be used as a lead molecule to develop novel analgesic agents. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/22658863/A_novel_franchetine_type_norditerpenoid_isolated_from_the_roots_of_Aconitum_carmichaeli_Debx__with_potential_analgesic_activity_and_less_toxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(12)00618-X DB - PRIME DP - Unbound Medicine ER -