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Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function.
Neuropharmacology. 2012 Oct; 63(5):776-83.N

Abstract

Cannabidiol (CBD) demonstrated short-term neuroprotective effects in the immature brain following hypoxia-ischemia (HI). We examined whether CBD neuroprotection is sustained over a prolonged period. Newborn Wistar rats underwent HI injury (10% oxygen for 120 min after left carotid artery electrocoagulation) and then received vehicle (HV, n = 22) or 1 mg/kg CBD (HC, n = 23). Sham animals were similarly treated (SV, n = 16 and SC, n = 16). The extent of brain damage was determined by magnetic resonance imaging, histological evaluation (neuropathological score, 0-5), magnetic resonance spectroscopy and Western blotting. Several neurobehavioral tests (RotaRod, cylinder rear test[CRT],and novel object recognition[NOR]) were carried out 30 days after HI (P37). CBD modulated brain excitotoxicity, oxidative stress and inflammation seven days after HI. We observed that HI led to long-lasting functional impairment, as observed in all neurobehavioral tests at P37, whereas the results of HC animals were similar to those of sham animals (all p < 0.05 vs. HV). CBD reduced brain infarct volume by 17% (p < 0.05) and lessened the extent of histological damage. No differences were observed between the SV and SC groups in any of the experiments. In conclusion, CBD administration after HI injury to newborn rats led to long-lasting neuroprotection, with the overall effect of promoting greater functional rather than histological recovery. These effects of CBD were not associated with any side effects. These results emphasize the interest in CBD as a neuroprotective agent for neonatal HI.

Authors+Show Affiliations

Experimental Unit, Foundation for Biomedical Research, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22659086

Citation

Pazos, M R., et al. "Cannabidiol Administration After Hypoxia-ischemia to Newborn Rats Reduces Long-term Brain Injury and Restores Neurobehavioral Function." Neuropharmacology, vol. 63, no. 5, 2012, pp. 776-83.
Pazos MR, Cinquina V, Gómez A, et al. Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function. Neuropharmacology. 2012;63(5):776-83.
Pazos, M. R., Cinquina, V., Gómez, A., Layunta, R., Santos, M., Fernández-Ruiz, J., & Martínez-Orgado, J. (2012). Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function. Neuropharmacology, 63(5), 776-83. https://doi.org/10.1016/j.neuropharm.2012.05.034
Pazos MR, et al. Cannabidiol Administration After Hypoxia-ischemia to Newborn Rats Reduces Long-term Brain Injury and Restores Neurobehavioral Function. Neuropharmacology. 2012;63(5):776-83. PubMed PMID: 22659086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function. AU - Pazos,M R, AU - Cinquina,V, AU - Gómez,A, AU - Layunta,R, AU - Santos,M, AU - Fernández-Ruiz,J, AU - Martínez-Orgado,José, Y1 - 2012/05/30/ PY - 2012/01/14/received PY - 2012/04/19/revised PY - 2012/05/24/accepted PY - 2012/6/5/entrez PY - 2012/6/5/pubmed PY - 2013/1/15/medline SP - 776 EP - 83 JF - Neuropharmacology JO - Neuropharmacology VL - 63 IS - 5 N2 - Cannabidiol (CBD) demonstrated short-term neuroprotective effects in the immature brain following hypoxia-ischemia (HI). We examined whether CBD neuroprotection is sustained over a prolonged period. Newborn Wistar rats underwent HI injury (10% oxygen for 120 min after left carotid artery electrocoagulation) and then received vehicle (HV, n = 22) or 1 mg/kg CBD (HC, n = 23). Sham animals were similarly treated (SV, n = 16 and SC, n = 16). The extent of brain damage was determined by magnetic resonance imaging, histological evaluation (neuropathological score, 0-5), magnetic resonance spectroscopy and Western blotting. Several neurobehavioral tests (RotaRod, cylinder rear test[CRT],and novel object recognition[NOR]) were carried out 30 days after HI (P37). CBD modulated brain excitotoxicity, oxidative stress and inflammation seven days after HI. We observed that HI led to long-lasting functional impairment, as observed in all neurobehavioral tests at P37, whereas the results of HC animals were similar to those of sham animals (all p < 0.05 vs. HV). CBD reduced brain infarct volume by 17% (p < 0.05) and lessened the extent of histological damage. No differences were observed between the SV and SC groups in any of the experiments. In conclusion, CBD administration after HI injury to newborn rats led to long-lasting neuroprotection, with the overall effect of promoting greater functional rather than histological recovery. These effects of CBD were not associated with any side effects. These results emphasize the interest in CBD as a neuroprotective agent for neonatal HI. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/22659086/Cannabidiol_administration_after_hypoxia_ischemia_to_newborn_rats_reduces_long_term_brain_injury_and_restores_neurobehavioral_function_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(12)00232-8 DB - PRIME DP - Unbound Medicine ER -