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Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice.
Behav Brain Res. 2012 Aug 01; 233(2):428-33.BB

Abstract

Neuropeptide FF (NPFF) belongs to a neuropeptide family including two receptors (NPFF(1) and NPFF(2)). NPFF system has been reported to play important roles in pain transmission. The aim of the present study was to investigate the roles of NPFF related peptides and their receptors in swim stress-induced analgesia (SIA). Nociceptive test was performed in mice stressed by forced swimming in water at 15 °C (cold water swimming) or 32 °C (warm water swimming). Warm water swimming produced a naloxone-mediated antinociceptive effect. This warm water swim SIA was dose-dependently antagonized by i.c.v. injection of NPFF and two related peptides (3-30 nmol), NPVF and dNPA, which exhibited the highest selectivities for NPFF(1) and NPFF(2) receptors, respectively. Moreover, the selective NPFF receptor antagonist RF9 (30 nmol) was inactive by itself, but prevented the effects of NPFF and related peptides. Cold-water swimming produced a wilder analgesic effect that was blocked by MK-801, but not naloxone. However, NPFF system failed to modify the cold water swim stress-induced analgesia. These findings demonstrated that NPFF and related peptides attenuated opioid-mediated form of SIA via NPFF receptors in the brain, but not non-opioid swim stress-induced analgesia. These data further support an anti-opioid character of NPFF system.

Authors+Show Affiliations

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology & Psychology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22659392

Citation

Li, Ning, et al. "Neuropeptide FF and Related Peptides Attenuates Warm-, but Not Cold-water Swim Stress-induced Analgesia in Mice." Behavioural Brain Research, vol. 233, no. 2, 2012, pp. 428-33.
Li N, Han ZL, Fang Q, et al. Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. Behav Brain Res. 2012;233(2):428-33.
Li, N., Han, Z. L., Fang, Q., Wang, Z. L., Tang, H. Z., Ren, H., & Wang, R. (2012). Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. Behavioural Brain Research, 233(2), 428-33. https://doi.org/10.1016/j.bbr.2012.05.035
Li N, et al. Neuropeptide FF and Related Peptides Attenuates Warm-, but Not Cold-water Swim Stress-induced Analgesia in Mice. Behav Brain Res. 2012 Aug 1;233(2):428-33. PubMed PMID: 22659392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. AU - Li,Ning, AU - Han,Zheng-lan, AU - Fang,Quan, AU - Wang,Zi-long, AU - Tang,Hong-zhu, AU - Ren,Hui, AU - Wang,Rui, Y1 - 2012/05/30/ PY - 2012/03/06/received PY - 2012/05/18/revised PY - 2012/05/22/accepted PY - 2012/6/5/entrez PY - 2012/6/5/pubmed PY - 2012/12/12/medline SP - 428 EP - 33 JF - Behavioural brain research JO - Behav Brain Res VL - 233 IS - 2 N2 - Neuropeptide FF (NPFF) belongs to a neuropeptide family including two receptors (NPFF(1) and NPFF(2)). NPFF system has been reported to play important roles in pain transmission. The aim of the present study was to investigate the roles of NPFF related peptides and their receptors in swim stress-induced analgesia (SIA). Nociceptive test was performed in mice stressed by forced swimming in water at 15 °C (cold water swimming) or 32 °C (warm water swimming). Warm water swimming produced a naloxone-mediated antinociceptive effect. This warm water swim SIA was dose-dependently antagonized by i.c.v. injection of NPFF and two related peptides (3-30 nmol), NPVF and dNPA, which exhibited the highest selectivities for NPFF(1) and NPFF(2) receptors, respectively. Moreover, the selective NPFF receptor antagonist RF9 (30 nmol) was inactive by itself, but prevented the effects of NPFF and related peptides. Cold-water swimming produced a wilder analgesic effect that was blocked by MK-801, but not naloxone. However, NPFF system failed to modify the cold water swim stress-induced analgesia. These findings demonstrated that NPFF and related peptides attenuated opioid-mediated form of SIA via NPFF receptors in the brain, but not non-opioid swim stress-induced analgesia. These data further support an anti-opioid character of NPFF system. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/22659392/Neuropeptide_FF_and_related_peptides_attenuates_warm__but_not_cold_water_swim_stress_induced_analgesia_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(12)00386-5 DB - PRIME DP - Unbound Medicine ER -