[Comparison of endoscopic band ligation and propranolol for the primary prophylaxis of variceal bleeding in cirrhosis].Zhong Nan Da Xue Xue Bao Yi Xue Ban 2012; 37(5):513-6ZN
To compare endoscopic variceal ligation (EVL) with propranolol for prophylaxis of first variceal bleeding.
We chose 168 patients with cirrhosis and esophageal varices in our hospital and allocated them to EVL and propranolol groups. Treatment effectiveness and safety in the 2 groups were observed.
he parameters of two groups were similar before therapy. Follow-up period was 8-36 months. Variceal bleeding occurred in 24 (28.6%) of the EVL group and in 20 (23.9%) of the propranolol group (P>0.05). Overall mortality and death related to bleeding were similar (21.4% vs 17.9%; 7.1% vs 6.0%, P>0.05). Adverse events related to EVL were 43 (3 of them life-threatening) compared to 16 in the propranolol group (51.19% vs 19.05%, P<0.05).
Propranolol may be the better choice in prophylaxis of variceal bleeding with similar effects and lower adverse events than with EVL.