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[Comparison of endoscopic band ligation and propranolol for the primary prophylaxis of variceal bleeding in cirrhosis].

Abstract

OBJECTIVE

To compare endoscopic variceal ligation (EVL) with propranolol for prophylaxis of first variceal bleeding.

METHODS

We chose 168 patients with cirrhosis and esophageal varices in our hospital and allocated them to EVL and propranolol groups. Treatment effectiveness and safety in the 2 groups were observed.

RESULTS

he parameters of two groups were similar before therapy. Follow-up period was 8-36 months. Variceal bleeding occurred in 24 (28.6%) of the EVL group and in 20 (23.9%) of the propranolol group (P>0.05). Overall mortality and death related to bleeding were similar (21.4% vs 17.9%; 7.1% vs 6.0%, P>0.05). Adverse events related to EVL were 43 (3 of them life-threatening) compared to 16 in the propranolol group (51.19% vs 19.05%, P<0.05).

CONCLUSION

Propranolol may be the better choice in prophylaxis of variceal bleeding with similar effects and lower adverse events than with EVL.

Authors+Show Affiliations

Department of General Surgery, Central South University, Changsha, China. fccc.1234@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

22659666

Citation

Feng, Chao, et al. "[Comparison of Endoscopic Band Ligation and Propranolol for the Primary Prophylaxis of Variceal Bleeding in Cirrhosis]." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 37, no. 5, 2012, pp. 513-6.
Feng C, Huang F, Nie W, et al. [Comparison of endoscopic band ligation and propranolol for the primary prophylaxis of variceal bleeding in cirrhosis]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012;37(5):513-6.
Feng, C., Huang, F., Nie, W., Liu, X., & Ren, S. (2012). [Comparison of endoscopic band ligation and propranolol for the primary prophylaxis of variceal bleeding in cirrhosis]. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 37(5), pp. 513-6. doi:10.3969/j.issn.1672-7347.2012.05.016.
Feng C, et al. [Comparison of Endoscopic Band Ligation and Propranolol for the Primary Prophylaxis of Variceal Bleeding in Cirrhosis]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012;37(5):513-6. PubMed PMID: 22659666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparison of endoscopic band ligation and propranolol for the primary prophylaxis of variceal bleeding in cirrhosis]. AU - Feng,Chao, AU - Huang,Feizhou, AU - Nie,Wanpin, AU - Liu,Xunyang, AU - Ren,Shuping, PY - 2012/6/5/entrez PY - 2012/6/5/pubmed PY - 2013/12/20/medline SP - 513 EP - 6 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 37 IS - 5 N2 - OBJECTIVE: To compare endoscopic variceal ligation (EVL) with propranolol for prophylaxis of first variceal bleeding. METHODS: We chose 168 patients with cirrhosis and esophageal varices in our hospital and allocated them to EVL and propranolol groups. Treatment effectiveness and safety in the 2 groups were observed. RESULTS: he parameters of two groups were similar before therapy. Follow-up period was 8-36 months. Variceal bleeding occurred in 24 (28.6%) of the EVL group and in 20 (23.9%) of the propranolol group (P>0.05). Overall mortality and death related to bleeding were similar (21.4% vs 17.9%; 7.1% vs 6.0%, P>0.05). Adverse events related to EVL were 43 (3 of them life-threatening) compared to 16 in the propranolol group (51.19% vs 19.05%, P<0.05). CONCLUSION: Propranolol may be the better choice in prophylaxis of variceal bleeding with similar effects and lower adverse events than with EVL. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/22659666/[Comparison_of_endoscopic_band_ligation_and_propranolol_for_the_primary_prophylaxis_of_variceal_bleeding_in_cirrhosis]_ L2 - http://xbyxb.csu.edu.cn/xbwk/fileup/PDF/201205513.pdf DB - PRIME DP - Unbound Medicine ER -