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[Neuroprotective effect of baicalein in patients with Parkinson's disease].
Zhongguo Zhong Yao Za Zhi. 2012 Feb; 37(4):421-5.ZZ

Abstract

Baicalein, a flavonoid compound extracted from dried roots of traditional Chinese medicine Scutellaria baicalensis, has been widely applied as an antioxidant and anti-inflammatory agent. With continuous studies on its mechanisms, recent findings suggest that baicalein has some effect on neuroprotection and improvement of clinical symptoms in neurodegenerative diseases such as Parkinson's disease. Recent studies showed that its neuroprotective efficacy is closely related to such functions as antiinflammatory, antioxidative stress, protecting chondriosome, inhibiting glutamate neurotoxicity, promoting nerve growth and inhibiting alpha-synuclein protein-aggregate activities. The aim of this article is to summarize the neuroprotective effects of baicalein in Parkinson's disease.

Authors+Show Affiliations

Yu X
Beijing Key laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
He G
No affiliation info available
Du G
No affiliation info available

MeSH

FlavanonesHumansMitochondriaNerve Growth FactorNeuroprotective AgentsOxidative StressParkinson Disease

Pub Type(s)

English Abstract
Journal Article
Review

Language

chi

PubMed ID

22667137

Citation

Yu, Xin, et al. "[Neuroprotective Effect of Baicalein in Patients With Parkinson's Disease]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 37, no. 4, 2012, pp. 421-5.
Yu X, He G, Du G. [Neuroprotective effect of baicalein in patients with Parkinson's disease]. Zhongguo Zhong Yao Za Zhi. 2012;37(4):421-5.
Yu, X., He, G., & Du, G. (2012). [Neuroprotective effect of baicalein in patients with Parkinson's disease]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 37(4), 421-5.
Yu X, He G, Du G. [Neuroprotective Effect of Baicalein in Patients With Parkinson's Disease]. Zhongguo Zhong Yao Za Zhi. 2012;37(4):421-5. PubMed PMID: 22667137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Neuroprotective effect of baicalein in patients with Parkinson's disease]. AU - Yu,Xin, AU - He,Guorong, AU - Du,Guanhua, PY - 2012/6/7/entrez PY - 2012/6/7/pubmed PY - 2012/7/12/medline SP - 421 EP - 5 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 37 IS - 4 N2 - Baicalein, a flavonoid compound extracted from dried roots of traditional Chinese medicine Scutellaria baicalensis, has been widely applied as an antioxidant and anti-inflammatory agent. With continuous studies on its mechanisms, recent findings suggest that baicalein has some effect on neuroprotection and improvement of clinical symptoms in neurodegenerative diseases such as Parkinson's disease. Recent studies showed that its neuroprotective efficacy is closely related to such functions as antiinflammatory, antioxidative stress, protecting chondriosome, inhibiting glutamate neurotoxicity, promoting nerve growth and inhibiting alpha-synuclein protein-aggregate activities. The aim of this article is to summarize the neuroprotective effects of baicalein in Parkinson's disease. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/22667137/[Neuroprotective_effect_of_baicalein_in_patients_with_Parkinson's_disease]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -