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Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa.
Clin Infect Dis. 2012 Sep; 55(6):e45-53.CI

Abstract

BACKGROUND

Chikungunya virus (CHIKV) and Dengue virus serotype 2 (DENV-2) were recently introduced in central Africa, along with Aedes albopictus. Simultaneous outbreaks of CHIKV and DENV-2 have subsequently occurred, in Cameroon in 2006 and Gabon in 2007.

METHODS

To study the spread of the 2 viruses, we conducted active surveillance of acute febrile syndromes throughout Gabon between 2007 and 2010. Diagnostic methods included quantitative real-time reverse-transcription polymerase chain reaction, and molecular characterization was based on partial envelope gene sequences.

RESULTS

Between 2007 and 2010, 4287 acutely febrile patients were investigated for CHIKV and DENV-2 infections, of whom 1567 were CHIKV-positive, 376 DENV-2-positive, and 37 coinfected. We diagnosed 153 CHIKV and 11 DENV-2 cases in 2008, and 5 CHIKV and 9 DENV-2 cases in 2009. In 2010, CHIKV and DENV-2 caused a second large simultaneous outbreak. Among 2826 acutely febrile patients examined during this outbreak, 1112 were CHIKV-positive, 288 DENV-2-positive, and 28 coinfected. Mosquitoes were collected near the homes of coinfected patients, and 1 Aedes albopictus specimen was found to be positive for both CHIKV and DENV-2.

CONCLUSIONS

These findings show the rapid dissemination of CHIKV and DENV-2 within a nonimmune population in a tropical African country, probably facilitated by the spread of Aedes albopictus. This has resulted in major simultaneous outbreaks with numerous coinfections in both human and mosquito.

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Authors+Show Affiliations

Caron M
Unité des Maladies Virales Emergentes, Centre International de Recherches Médicales de Franceville, Gabon. melaniecaron.cirmf@gmail.com
Paupy C
No affiliation info available
Grard G
No affiliation info available
Becquart P
No affiliation info available
Mombo I
No affiliation info available
Nso BB
No affiliation info available
Kassa Kassa F
No affiliation info available
Nkoghe D
No affiliation info available
Leroy EM
No affiliation info available

MeSH

AdolescentAdultAedesAgedAged, 80 and overAlphavirus InfectionsAnimalsChikungunya virusChildChild, PreschoolCoinfectionDengueDengue VirusDisease OutbreaksFemaleGabonHumansInfantMaleMiddle AgedMolecular EpidemiologyMolecular Sequence DataReal-Time Polymerase Chain ReactionSequence Analysis, DNAViral Envelope ProteinsYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22670036

Citation

Caron, Mélanie, et al. "Recent Introduction and Rapid Dissemination of Chikungunya Virus and Dengue Virus Serotype 2 Associated With Human and Mosquito Coinfections in Gabon, Central Africa." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 55, no. 6, 2012, pp. e45-53.
Caron M, Paupy C, Grard G, et al. Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa. Clin Infect Dis. 2012;55(6):e45-53.
Caron, M., Paupy, C., Grard, G., Becquart, P., Mombo, I., Nso, B. B., Kassa Kassa, F., Nkoghe, D., & Leroy, E. M. (2012). Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 55(6), e45-53. https://doi.org/10.1093/cid/cis530
Caron M, et al. Recent Introduction and Rapid Dissemination of Chikungunya Virus and Dengue Virus Serotype 2 Associated With Human and Mosquito Coinfections in Gabon, Central Africa. Clin Infect Dis. 2012;55(6):e45-53. PubMed PMID: 22670036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa. AU - Caron,Mélanie, AU - Paupy,Christophe, AU - Grard,Gilda, AU - Becquart,Pierre, AU - Mombo,Illich, AU - Nso,Branly Bikie Bi, AU - Kassa Kassa,Fabrice, AU - Nkoghe,Dieudonné, AU - Leroy,Eric Maurice, Y1 - 2012/06/05/ PY - 2012/6/7/entrez PY - 2012/6/7/pubmed PY - 2013/1/9/medline SP - e45 EP - 53 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 55 IS - 6 N2 - BACKGROUND: Chikungunya virus (CHIKV) and Dengue virus serotype 2 (DENV-2) were recently introduced in central Africa, along with Aedes albopictus. Simultaneous outbreaks of CHIKV and DENV-2 have subsequently occurred, in Cameroon in 2006 and Gabon in 2007. METHODS: To study the spread of the 2 viruses, we conducted active surveillance of acute febrile syndromes throughout Gabon between 2007 and 2010. Diagnostic methods included quantitative real-time reverse-transcription polymerase chain reaction, and molecular characterization was based on partial envelope gene sequences. RESULTS: Between 2007 and 2010, 4287 acutely febrile patients were investigated for CHIKV and DENV-2 infections, of whom 1567 were CHIKV-positive, 376 DENV-2-positive, and 37 coinfected. We diagnosed 153 CHIKV and 11 DENV-2 cases in 2008, and 5 CHIKV and 9 DENV-2 cases in 2009. In 2010, CHIKV and DENV-2 caused a second large simultaneous outbreak. Among 2826 acutely febrile patients examined during this outbreak, 1112 were CHIKV-positive, 288 DENV-2-positive, and 28 coinfected. Mosquitoes were collected near the homes of coinfected patients, and 1 Aedes albopictus specimen was found to be positive for both CHIKV and DENV-2. CONCLUSIONS: These findings show the rapid dissemination of CHIKV and DENV-2 within a nonimmune population in a tropical African country, probably facilitated by the spread of Aedes albopictus. This has resulted in major simultaneous outbreaks with numerous coinfections in both human and mosquito. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/22670036/Recent_introduction_and_rapid_dissemination_of_Chikungunya_virus_and_Dengue_virus_serotype_2_associated_with_human_and_mosquito_coinfections_in_Gabon_central_Africa_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cis530 DB - PRIME DP - Unbound Medicine ER -