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Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa.
Clin Infect Dis. 2012 Sep; 55(6):e45-53.CI

Abstract

BACKGROUND

Chikungunya virus (CHIKV) and Dengue virus serotype 2 (DENV-2) were recently introduced in central Africa, along with Aedes albopictus. Simultaneous outbreaks of CHIKV and DENV-2 have subsequently occurred, in Cameroon in 2006 and Gabon in 2007.

METHODS

To study the spread of the 2 viruses, we conducted active surveillance of acute febrile syndromes throughout Gabon between 2007 and 2010. Diagnostic methods included quantitative real-time reverse-transcription polymerase chain reaction, and molecular characterization was based on partial envelope gene sequences.

RESULTS

Between 2007 and 2010, 4287 acutely febrile patients were investigated for CHIKV and DENV-2 infections, of whom 1567 were CHIKV-positive, 376 DENV-2-positive, and 37 coinfected. We diagnosed 153 CHIKV and 11 DENV-2 cases in 2008, and 5 CHIKV and 9 DENV-2 cases in 2009. In 2010, CHIKV and DENV-2 caused a second large simultaneous outbreak. Among 2826 acutely febrile patients examined during this outbreak, 1112 were CHIKV-positive, 288 DENV-2-positive, and 28 coinfected. Mosquitoes were collected near the homes of coinfected patients, and 1 Aedes albopictus specimen was found to be positive for both CHIKV and DENV-2.

CONCLUSIONS

These findings show the rapid dissemination of CHIKV and DENV-2 within a nonimmune population in a tropical African country, probably facilitated by the spread of Aedes albopictus. This has resulted in major simultaneous outbreaks with numerous coinfections in both human and mosquito.

Authors+Show Affiliations

Unité des Maladies Virales Emergentes, Centre International de Recherches Médicales de Franceville, Gabon. melaniecaron.cirmf@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22670036

Citation

Caron, Mélanie, et al. "Recent Introduction and Rapid Dissemination of Chikungunya Virus and Dengue Virus Serotype 2 Associated With Human and Mosquito Coinfections in Gabon, Central Africa." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 55, no. 6, 2012, pp. e45-53.
Caron M, Paupy C, Grard G, et al. Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa. Clin Infect Dis. 2012;55(6):e45-53.
Caron, M., Paupy, C., Grard, G., Becquart, P., Mombo, I., Nso, B. B., Kassa Kassa, F., Nkoghe, D., & Leroy, E. M. (2012). Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 55(6), e45-53. https://doi.org/10.1093/cid/cis530
Caron M, et al. Recent Introduction and Rapid Dissemination of Chikungunya Virus and Dengue Virus Serotype 2 Associated With Human and Mosquito Coinfections in Gabon, Central Africa. Clin Infect Dis. 2012;55(6):e45-53. PubMed PMID: 22670036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa. AU - Caron,Mélanie, AU - Paupy,Christophe, AU - Grard,Gilda, AU - Becquart,Pierre, AU - Mombo,Illich, AU - Nso,Branly Bikie Bi, AU - Kassa Kassa,Fabrice, AU - Nkoghe,Dieudonné, AU - Leroy,Eric Maurice, Y1 - 2012/06/05/ PY - 2012/6/7/entrez PY - 2012/6/7/pubmed PY - 2013/1/9/medline SP - e45 EP - 53 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 55 IS - 6 N2 - BACKGROUND: Chikungunya virus (CHIKV) and Dengue virus serotype 2 (DENV-2) were recently introduced in central Africa, along with Aedes albopictus. Simultaneous outbreaks of CHIKV and DENV-2 have subsequently occurred, in Cameroon in 2006 and Gabon in 2007. METHODS: To study the spread of the 2 viruses, we conducted active surveillance of acute febrile syndromes throughout Gabon between 2007 and 2010. Diagnostic methods included quantitative real-time reverse-transcription polymerase chain reaction, and molecular characterization was based on partial envelope gene sequences. RESULTS: Between 2007 and 2010, 4287 acutely febrile patients were investigated for CHIKV and DENV-2 infections, of whom 1567 were CHIKV-positive, 376 DENV-2-positive, and 37 coinfected. We diagnosed 153 CHIKV and 11 DENV-2 cases in 2008, and 5 CHIKV and 9 DENV-2 cases in 2009. In 2010, CHIKV and DENV-2 caused a second large simultaneous outbreak. Among 2826 acutely febrile patients examined during this outbreak, 1112 were CHIKV-positive, 288 DENV-2-positive, and 28 coinfected. Mosquitoes were collected near the homes of coinfected patients, and 1 Aedes albopictus specimen was found to be positive for both CHIKV and DENV-2. CONCLUSIONS: These findings show the rapid dissemination of CHIKV and DENV-2 within a nonimmune population in a tropical African country, probably facilitated by the spread of Aedes albopictus. This has resulted in major simultaneous outbreaks with numerous coinfections in both human and mosquito. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/22670036/Recent_introduction_and_rapid_dissemination_of_Chikungunya_virus_and_Dengue_virus_serotype_2_associated_with_human_and_mosquito_coinfections_in_Gabon_central_Africa_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cis530 DB - PRIME DP - Unbound Medicine ER -