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Antioxidant, antihyperglycemic, and antihyperlipidemic effects of Coriandrum sativum leaf and stem in alloxan-induced diabetic rats.
J Food Sci. 2012 Jul; 77(7):T119-23.JF

Abstract

In India's indigenous system of medicine, Coriandrum sativum (CS), commonly used as a food ingredient, is claimed to be useful for various ailments. To establish its utility in diabetes mellitus, the present study evaluated the antidiabetic and antioxidant effects of CS in alloxan-induced diabetic rats. The extracts were shown to contain bioactive compounds including phenolics, flavonoids, steroids, and tannins. The extracts of CS in alloxan-induced diabetic rats were found to significantly lower blood glucose levels. Antidiabetic activity of the CS extracts was compared with the clinically available drug glibenclamide. The levels of serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol were lower in the extract-treated group and high-density lipoprotein cholesterol was higher than the diabetic control rats. The extracts of CS exhibited strong scavenging effect on 2, 2-diphenyl-2-picrylhydrazyl free radical and inhibition of lipid peroxidation. The free radical scavenging effect of the extracts was comparable with that of the reference antioxidants. Furthermore, it also showed an improved antioxidant potential as evidenced by decreased lipid peroxidation and a significant increase in the activity of various antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase in the liver of diabetic rats. These results indicate that the extracts could protect liver function and exhibited hypoglycemic, hypolipidemic, and antioxidant efficacies in the diabetic rats. These results support the use of this plant extract to manage diabetes mellitus.

PRACTICAL APPLICATIONS

The leaves and stem of this plant Coriandrum sativum if used in cuisine would be a remedy for diabetes.

Authors+Show Affiliations

School of Life Science, Bharathidasan Univ, Palkalaiperur, Tiruchirappalli, Tamil Nadu, India. sree_latha04@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22671941

Citation

Sreelatha, S, and R Inbavalli. "Antioxidant, Antihyperglycemic, and Antihyperlipidemic Effects of Coriandrum Sativum Leaf and Stem in Alloxan-induced Diabetic Rats." Journal of Food Science, vol. 77, no. 7, 2012, pp. T119-23.
Sreelatha S, Inbavalli R. Antioxidant, antihyperglycemic, and antihyperlipidemic effects of Coriandrum sativum leaf and stem in alloxan-induced diabetic rats. J Food Sci. 2012;77(7):T119-23.
Sreelatha, S., & Inbavalli, R. (2012). Antioxidant, antihyperglycemic, and antihyperlipidemic effects of Coriandrum sativum leaf and stem in alloxan-induced diabetic rats. Journal of Food Science, 77(7), T119-23. https://doi.org/10.1111/j.1750-3841.2012.02755.x
Sreelatha S, Inbavalli R. Antioxidant, Antihyperglycemic, and Antihyperlipidemic Effects of Coriandrum Sativum Leaf and Stem in Alloxan-induced Diabetic Rats. J Food Sci. 2012;77(7):T119-23. PubMed PMID: 22671941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant, antihyperglycemic, and antihyperlipidemic effects of Coriandrum sativum leaf and stem in alloxan-induced diabetic rats. AU - Sreelatha,S, AU - Inbavalli,R, Y1 - 2012/06/01/ PY - 2012/6/8/entrez PY - 2012/6/8/pubmed PY - 2012/11/10/medline SP - T119 EP - 23 JF - Journal of food science JO - J Food Sci VL - 77 IS - 7 N2 - UNLABELLED: In India's indigenous system of medicine, Coriandrum sativum (CS), commonly used as a food ingredient, is claimed to be useful for various ailments. To establish its utility in diabetes mellitus, the present study evaluated the antidiabetic and antioxidant effects of CS in alloxan-induced diabetic rats. The extracts were shown to contain bioactive compounds including phenolics, flavonoids, steroids, and tannins. The extracts of CS in alloxan-induced diabetic rats were found to significantly lower blood glucose levels. Antidiabetic activity of the CS extracts was compared with the clinically available drug glibenclamide. The levels of serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol were lower in the extract-treated group and high-density lipoprotein cholesterol was higher than the diabetic control rats. The extracts of CS exhibited strong scavenging effect on 2, 2-diphenyl-2-picrylhydrazyl free radical and inhibition of lipid peroxidation. The free radical scavenging effect of the extracts was comparable with that of the reference antioxidants. Furthermore, it also showed an improved antioxidant potential as evidenced by decreased lipid peroxidation and a significant increase in the activity of various antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase in the liver of diabetic rats. These results indicate that the extracts could protect liver function and exhibited hypoglycemic, hypolipidemic, and antioxidant efficacies in the diabetic rats. These results support the use of this plant extract to manage diabetes mellitus. PRACTICAL APPLICATIONS: The leaves and stem of this plant Coriandrum sativum if used in cuisine would be a remedy for diabetes. SN - 1750-3841 UR - https://www.unboundmedicine.com/medline/citation/22671941/Antioxidant_antihyperglycemic_and_antihyperlipidemic_effects_of_Coriandrum_sativum_leaf_and_stem_in_alloxan_induced_diabetic_rats_ L2 - https://doi.org/10.1111/j.1750-3841.2012.02755.x DB - PRIME DP - Unbound Medicine ER -