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Diabetes incidence does not differ between subjects with and without high depressive symptoms--5-year follow-up results of the Heinz Nixdorf Recall Study.
Diabet Med 2013; 30(1):65-9DM

Abstract

AIMS

Cross-sectional studies have consistently reported evidence for an association between diabetes and depressive disorders. However, only limited prospective studies have examined this association, reporting conflicting results. In a population-based cohort study, we compared cumulative incidences of diabetes between participants with and without high depressive symptoms.

METHOD

We analysed the 5-year follow-up data from the German Heinz Nixdorf Recall study of 3547 participants without diabetes at baseline [mean age 58.8 (sd 7.6) years, 47.5% male]. Depressive symptoms were defined using the Centre for Epidemiologic Studies Depression scale (cut point ≥ 17). Diabetes (diagnosed or previously undetected) was identified by self-reported physician-diagnosed diabetes, medication and high blood glucose levels. We estimated 5-year cumulative incidences with 95% confidence intervals and fitted multiple logistic regression models to calculate the odds ratios, adjusted for age, sex, physical activity, smoking, living with or without partner, and educational level.

RESULTS

The cumulative incidence of diabetes was 9.2% (95% CI 6.3-12.8) in participants with high depressive symptoms at baseline and 9.0% (95% CI 8.0-10.0) in participants without these symptoms. The age- and sex-adjusted odds ratio of diabetes in participants with depressive symptoms compared with those without was 1.13 [95% CI 0.77-1.68; fully adjusted 1.11 (95% CI 0.74-1.65)]. These results did not substantially change in several additional sensitivity analyses.

CONCLUSION

Our study did not show a significantly increased risk of developing diabetes in individuals with high depressive symptoms compared with those without high depressive symptoms during a 5-year follow-up period.

Authors+Show Affiliations

Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich Heine University Düsseldorf, Düsseldorf, Germany. andrea.icks@ddz.uni-duesseldorf.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22672118

Citation

Icks, A, et al. "Diabetes Incidence Does Not Differ Between Subjects With and Without High Depressive Symptoms--5-year Follow-up Results of the Heinz Nixdorf Recall Study." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 30, no. 1, 2013, pp. 65-9.
Icks A, Albers B, Haastert B, et al. Diabetes incidence does not differ between subjects with and without high depressive symptoms--5-year follow-up results of the Heinz Nixdorf Recall Study. Diabet Med. 2013;30(1):65-9.
Icks, A., Albers, B., Haastert, B., Pechlivanis, S., Bokhof, B., Slomiany, U., ... Moebus, S. (2013). Diabetes incidence does not differ between subjects with and without high depressive symptoms--5-year follow-up results of the Heinz Nixdorf Recall Study. Diabetic Medicine : a Journal of the British Diabetic Association, 30(1), pp. 65-9. doi:10.1111/j.1464-5491.2012.03724.x.
Icks A, et al. Diabetes Incidence Does Not Differ Between Subjects With and Without High Depressive Symptoms--5-year Follow-up Results of the Heinz Nixdorf Recall Study. Diabet Med. 2013;30(1):65-9. PubMed PMID: 22672118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes incidence does not differ between subjects with and without high depressive symptoms--5-year follow-up results of the Heinz Nixdorf Recall Study. AU - Icks,A, AU - Albers,B, AU - Haastert,B, AU - Pechlivanis,S, AU - Bokhof,B, AU - Slomiany,U, AU - Erbel,R, AU - Jöckel,K-H, AU - Kruse,J, AU - Nowotny,B, AU - Herder,C, AU - Giani,G, AU - Moebus,S, AU - ,, AU - ,, PY - 2012/6/8/entrez PY - 2012/6/8/pubmed PY - 2013/5/18/medline SP - 65 EP - 9 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 30 IS - 1 N2 - AIMS: Cross-sectional studies have consistently reported evidence for an association between diabetes and depressive disorders. However, only limited prospective studies have examined this association, reporting conflicting results. In a population-based cohort study, we compared cumulative incidences of diabetes between participants with and without high depressive symptoms. METHOD: We analysed the 5-year follow-up data from the German Heinz Nixdorf Recall study of 3547 participants without diabetes at baseline [mean age 58.8 (sd 7.6) years, 47.5% male]. Depressive symptoms were defined using the Centre for Epidemiologic Studies Depression scale (cut point ≥ 17). Diabetes (diagnosed or previously undetected) was identified by self-reported physician-diagnosed diabetes, medication and high blood glucose levels. We estimated 5-year cumulative incidences with 95% confidence intervals and fitted multiple logistic regression models to calculate the odds ratios, adjusted for age, sex, physical activity, smoking, living with or without partner, and educational level. RESULTS: The cumulative incidence of diabetes was 9.2% (95% CI 6.3-12.8) in participants with high depressive symptoms at baseline and 9.0% (95% CI 8.0-10.0) in participants without these symptoms. The age- and sex-adjusted odds ratio of diabetes in participants with depressive symptoms compared with those without was 1.13 [95% CI 0.77-1.68; fully adjusted 1.11 (95% CI 0.74-1.65)]. These results did not substantially change in several additional sensitivity analyses. CONCLUSION: Our study did not show a significantly increased risk of developing diabetes in individuals with high depressive symptoms compared with those without high depressive symptoms during a 5-year follow-up period. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/22672118/Diabetes_incidence_does_not_differ_between_subjects_with_and_without_high_depressive_symptoms__5_year_follow_up_results_of_the_Heinz_Nixdorf_Recall_Study_ L2 - https://doi.org/10.1111/j.1464-5491.2012.03724.x DB - PRIME DP - Unbound Medicine ER -