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A pilot randomized controlled trial of an oral care intervention to reduce mucositis severity in stem cell transplant patients.
J Pain Symptom Manage. 2012 Jul; 44(1):64-73.JP

Abstract

CONTEXT

Oral mucositis remains a significant problem in autologous stem cell transplantation (ASCT).

OBJECTIVES

This pilot trial assessed the effectiveness of oral cryotherapy plus an oral care protocol in reducing oral mucositis severity in ASCT patients.

METHODS

Patients admitted for ASCT were randomly allocated to either the experimental arm (n=23) or usual care (n=23). All participants received information on principles of good oral hygiene and skills training in oral self-care. Patients in the experimental arm had a 60-minute regimen of oral cryotherapy. The primary outcome of oral mucositis severity and secondary outcomes of mucositis-related pain and functional intake of food and fluids were measured at Days -1, 3, 6, 9, and 12. Length of hospital stay was determined by counting backward from discharge day to admission. Perception of tolerability and acceptability of the 60-minute cryotherapy and frequency of the oral care regimen also were assessed.

RESULTS

Forty-eight patients were recruited at the study site in six months. The overall mean (SE) of oral mucositis severity for the experimental arm was significantly lower than that for the control group: 0.43 (0.12) vs. 1.14 (0.12); P<0.001, on a 0-4 scale. The overall mean (SE) mucositis-related pain score for the experimental arm also was significantly lower than that for the control group: 0.30 (0.23) vs. 1.64 (0.24); P<0.001, on a 0-10 scale.

CONCLUSION

Oral cryotherapy plus an oral care protocol appears to be beneficial in reducing severity of mucositis compared with an oral care protocol alone.

Authors+Show Affiliations

Princess Margaret Hospital, Toronto, Ontario, Canada. prisco.salvador@uhn.on.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22672917

Citation

Salvador, Prisco, et al. "A Pilot Randomized Controlled Trial of an Oral Care Intervention to Reduce Mucositis Severity in Stem Cell Transplant Patients." Journal of Pain and Symptom Management, vol. 44, no. 1, 2012, pp. 64-73.
Salvador P, Azusano C, Wang L, et al. A pilot randomized controlled trial of an oral care intervention to reduce mucositis severity in stem cell transplant patients. J Pain Symptom Manage. 2012;44(1):64-73.
Salvador, P., Azusano, C., Wang, L., & Howell, D. (2012). A pilot randomized controlled trial of an oral care intervention to reduce mucositis severity in stem cell transplant patients. Journal of Pain and Symptom Management, 44(1), 64-73. https://doi.org/10.1016/j.jpainsymman.2011.08.012
Salvador P, et al. A Pilot Randomized Controlled Trial of an Oral Care Intervention to Reduce Mucositis Severity in Stem Cell Transplant Patients. J Pain Symptom Manage. 2012;44(1):64-73. PubMed PMID: 22672917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pilot randomized controlled trial of an oral care intervention to reduce mucositis severity in stem cell transplant patients. AU - Salvador,Prisco, AU - Azusano,Cristina, AU - Wang,Lisa, AU - Howell,Doris, Y1 - 2012/06/05/ PY - 2011/02/26/received PY - 2011/08/23/revised PY - 2011/09/01/accepted PY - 2012/6/8/entrez PY - 2012/6/8/pubmed PY - 2013/1/23/medline SP - 64 EP - 73 JF - Journal of pain and symptom management JO - J Pain Symptom Manage VL - 44 IS - 1 N2 - CONTEXT: Oral mucositis remains a significant problem in autologous stem cell transplantation (ASCT). OBJECTIVES: This pilot trial assessed the effectiveness of oral cryotherapy plus an oral care protocol in reducing oral mucositis severity in ASCT patients. METHODS: Patients admitted for ASCT were randomly allocated to either the experimental arm (n=23) or usual care (n=23). All participants received information on principles of good oral hygiene and skills training in oral self-care. Patients in the experimental arm had a 60-minute regimen of oral cryotherapy. The primary outcome of oral mucositis severity and secondary outcomes of mucositis-related pain and functional intake of food and fluids were measured at Days -1, 3, 6, 9, and 12. Length of hospital stay was determined by counting backward from discharge day to admission. Perception of tolerability and acceptability of the 60-minute cryotherapy and frequency of the oral care regimen also were assessed. RESULTS: Forty-eight patients were recruited at the study site in six months. The overall mean (SE) of oral mucositis severity for the experimental arm was significantly lower than that for the control group: 0.43 (0.12) vs. 1.14 (0.12); P<0.001, on a 0-4 scale. The overall mean (SE) mucositis-related pain score for the experimental arm also was significantly lower than that for the control group: 0.30 (0.23) vs. 1.64 (0.24); P<0.001, on a 0-10 scale. CONCLUSION: Oral cryotherapy plus an oral care protocol appears to be beneficial in reducing severity of mucositis compared with an oral care protocol alone. SN - 1873-6513 UR - https://www.unboundmedicine.com/medline/citation/22672917/A_pilot_randomized_controlled_trial_of_an_oral_care_intervention_to_reduce_mucositis_severity_in_stem_cell_transplant_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0885-3924(12)00142-X DB - PRIME DP - Unbound Medicine ER -