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Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients.
Endocr J. 2012; 59(8):685-95.EJ

Abstract

In patients with end-stage renal disease (ESRD), circulating adipokine levels are increased due to decreased renal clearance, irrespective of obesity. However, whether adipokines play a role in the development of insulin resistance (IR) in non-obese ESRD patients is unknown. We conducted a cross-sectional study to identify factors associated with IR in 62 non-obese patients on peritoneal dialysis (PD). Non-obesity was defined as body mass index (BMI) <25 kg/m(2). IR was determined using homeostatic model assessment-IR (HOMA-IR). We also measured serum concentrations of adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hsCRP), and IL-6. The average BMI of the study patients was 21.6 kg/m(2). When patients were divided into two groups according to the median value of HOMA-IR, serum adiponectin levels were significantly lower in patients with HOMA-IR > 1.85 than in those with HOMA-IR ≤1.85, whereas serum concentrations of leptin and resistin did not differ between the two groups. In addition, log-transformed HOMA-IR was negatively correlated with adiponectin (γ = -0.464, P < 0.001) and log-transformed high-density lipoprotein cholesterol (γ = -0.250, P = 0.050) and positively correlated with age (γ = 0.334, P = 0.008) and triglyceride (γ = 0.392, P = 0.002). However, resistin, log-transformed leptin and log-transformed hsCRP were not associated with HOMA-IR. In a multiple linear regression model, adiponectin was independently associated with HOMA-IR (β = -0.023, P = 0.015). In conclusion, this study suggests that low circulating adiponectin levels might be involved in IR even in non-obese patients undergoing PD.

Authors+Show Affiliations

Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22673293

Citation

Yoo, Dong Eun, et al. "Low Circulating Adiponectin Levels Are Associated With Insulin Resistance in Non-obese Peritoneal Dialysis Patients." Endocrine Journal, vol. 59, no. 8, 2012, pp. 685-95.
Yoo DE, Lee MJ, Oh HJ, et al. Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients. Endocr J. 2012;59(8):685-95.
Yoo, D. E., Lee, M. J., Oh, H. J., Kim, S. J., Shin, D. H., Yoo, T. H., Kang, S. W., Choi, K. H., Han, D. S., & Han, S. H. (2012). Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients. Endocrine Journal, 59(8), 685-95.
Yoo DE, et al. Low Circulating Adiponectin Levels Are Associated With Insulin Resistance in Non-obese Peritoneal Dialysis Patients. Endocr J. 2012;59(8):685-95. PubMed PMID: 22673293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients. AU - Yoo,Dong Eun, AU - Lee,Mi Jung, AU - Oh,Hyung Jung, AU - Kim,Seung Jun, AU - Shin,Dong Ho, AU - Yoo,Tae-Hyun, AU - Kang,Shin-Wook, AU - Choi,Kyu Hun, AU - Han,Dae Suk, AU - Han,Seung Hyeok, Y1 - 2012/05/12/ PY - 2012/6/8/entrez PY - 2012/6/8/pubmed PY - 2013/1/31/medline SP - 685 EP - 95 JF - Endocrine journal JO - Endocr. J. VL - 59 IS - 8 N2 - In patients with end-stage renal disease (ESRD), circulating adipokine levels are increased due to decreased renal clearance, irrespective of obesity. However, whether adipokines play a role in the development of insulin resistance (IR) in non-obese ESRD patients is unknown. We conducted a cross-sectional study to identify factors associated with IR in 62 non-obese patients on peritoneal dialysis (PD). Non-obesity was defined as body mass index (BMI) <25 kg/m(2). IR was determined using homeostatic model assessment-IR (HOMA-IR). We also measured serum concentrations of adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hsCRP), and IL-6. The average BMI of the study patients was 21.6 kg/m(2). When patients were divided into two groups according to the median value of HOMA-IR, serum adiponectin levels were significantly lower in patients with HOMA-IR > 1.85 than in those with HOMA-IR ≤1.85, whereas serum concentrations of leptin and resistin did not differ between the two groups. In addition, log-transformed HOMA-IR was negatively correlated with adiponectin (γ = -0.464, P < 0.001) and log-transformed high-density lipoprotein cholesterol (γ = -0.250, P = 0.050) and positively correlated with age (γ = 0.334, P = 0.008) and triglyceride (γ = 0.392, P = 0.002). However, resistin, log-transformed leptin and log-transformed hsCRP were not associated with HOMA-IR. In a multiple linear regression model, adiponectin was independently associated with HOMA-IR (β = -0.023, P = 0.015). In conclusion, this study suggests that low circulating adiponectin levels might be involved in IR even in non-obese patients undergoing PD. SN - 1348-4540 UR - https://www.unboundmedicine.com/medline/citation/22673293/Low_circulating_adiponectin_levels_are_associated_with_insulin_resistance_in_non_obese_peritoneal_dialysis_patients_ L2 - https://joi.jlc.jst.go.jp/DN/JST.JSTAGE/endocrj/EJ12-0032?from=PubMed DB - PRIME DP - Unbound Medicine ER -