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The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention.
Hum Brain Mapp. 2013 Nov; 34(11):2972-85.HB

Abstract

Cerebral white matter (WM) degeneration occurs with increasing age and is associated with declining cognitive function. Research has shown that cardiorespiratory fitness and exercise are effective as protective, even restorative, agents against cognitive and neurobiological impairments in older adults. In this study, we investigated whether the beneficial impact of aerobic fitness would extend to WM integrity in the context of a one-year exercise intervention. Further, we examined the pattern of diffusivity changes to better understand the underlying biological mechanisms. Finally, we assessed whether training-induced changes in WM integrity would be associated with improvements in cognitive performance independent of aerobic fitness gains. Results showed that aerobic fitness training did not affect group-level change in WM integrity, executive function, or short-term memory, but that greater aerobic fitness derived from the walking program was associated with greater change in WM integrity in the frontal and temporal lobes, and greater improvement in short-term memory. Increases in WM integrity, however, were not associated with short-term memory improvement, independent of fitness improvements. Therefore, while not all findings are consistent with previous research, we provide novel evidence for correlated change in training-induced aerobic fitness, WM integrity, and cognition among healthy older adults.

Authors+Show Affiliations

Department of Psychology, The University of Iowa, Iowa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22674729

Citation

Voss, Michelle W., et al. "The Influence of Aerobic Fitness On Cerebral White Matter Integrity and Cognitive Function in Older Adults: Results of a One-year Exercise Intervention." Human Brain Mapping, vol. 34, no. 11, 2013, pp. 2972-85.
Voss MW, Heo S, Prakash RS, et al. The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Mapp. 2013;34(11):2972-85.
Voss, M. W., Heo, S., Prakash, R. S., Erickson, K. I., Alves, H., Chaddock, L., Szabo, A. N., Mailey, E. L., Wójcicki, T. R., White, S. M., Gothe, N., McAuley, E., Sutton, B. P., & Kramer, A. F. (2013). The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Human Brain Mapping, 34(11), 2972-85. https://doi.org/10.1002/hbm.22119
Voss MW, et al. The Influence of Aerobic Fitness On Cerebral White Matter Integrity and Cognitive Function in Older Adults: Results of a One-year Exercise Intervention. Hum Brain Mapp. 2013;34(11):2972-85. PubMed PMID: 22674729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. AU - Voss,Michelle W, AU - Heo,Susie, AU - Prakash,Ruchika S, AU - Erickson,Kirk I, AU - Alves,Heloisa, AU - Chaddock,Laura, AU - Szabo,Amanda N, AU - Mailey,Emily L, AU - Wójcicki,Thomas R, AU - White,Siobhan M, AU - Gothe,Neha, AU - McAuley,Edward, AU - Sutton,Bradley P, AU - Kramer,Arthur F, Y1 - 2012/06/05/ PY - 2010/12/21/received PY - 2012/02/13/revised PY - 2012/04/05/accepted PY - 2012/6/8/entrez PY - 2012/6/8/pubmed PY - 2014/5/29/medline KW - aging KW - anisotropy KW - cerebrum KW - cognition KW - diffusion tensor imaging KW - physical fitness SP - 2972 EP - 85 JF - Human brain mapping JO - Hum Brain Mapp VL - 34 IS - 11 N2 - Cerebral white matter (WM) degeneration occurs with increasing age and is associated with declining cognitive function. Research has shown that cardiorespiratory fitness and exercise are effective as protective, even restorative, agents against cognitive and neurobiological impairments in older adults. In this study, we investigated whether the beneficial impact of aerobic fitness would extend to WM integrity in the context of a one-year exercise intervention. Further, we examined the pattern of diffusivity changes to better understand the underlying biological mechanisms. Finally, we assessed whether training-induced changes in WM integrity would be associated with improvements in cognitive performance independent of aerobic fitness gains. Results showed that aerobic fitness training did not affect group-level change in WM integrity, executive function, or short-term memory, but that greater aerobic fitness derived from the walking program was associated with greater change in WM integrity in the frontal and temporal lobes, and greater improvement in short-term memory. Increases in WM integrity, however, were not associated with short-term memory improvement, independent of fitness improvements. Therefore, while not all findings are consistent with previous research, we provide novel evidence for correlated change in training-induced aerobic fitness, WM integrity, and cognition among healthy older adults. SN - 1097-0193 UR - https://www.unboundmedicine.com/medline/citation/22674729/The_influence_of_aerobic_fitness_on_cerebral_white_matter_integrity_and_cognitive_function_in_older_adults:_results_of_a_one_year_exercise_intervention_ L2 - https://doi.org/10.1002/hbm.22119 DB - PRIME DP - Unbound Medicine ER -