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An approach to the continuous dopaminergic stimulation in Parkinson's disease.
Isr Med Assoc J. 2012 Mar; 14(3):175-9.IM

Abstract

Dopaminergic neurons in the basal ganglia normally fire in a continuous manner, maintaining the striatal dopamine concentration at a relatively constant level. In Parkinson's disease, dopaminergic treatment produces a discontinuous stimulation, inducing an intermittent pulsatile activation of the striatal receptors. It is likely that the oscillations in the dopamine level in the striatum contribute to the development of motor complications. Treatment with long-acting dopaminergic agents, or providing a more continuous dopaminergic effect in the striatum, has been associated with fewer clinical motor complications. This review describes the state-of-the-art approach to achieve the desired continuous dopaminergic stimulation, providing patients with the best clinical effect and probably minimal motor complications.

Authors+Show Affiliations

Department of Neurology, Bnai Zion Medical Center, Haifa, Israel. miguel@netvision.net.ilNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22675859

Citation

Schwartz, Miguel, and Sergiu Sabetay. "An Approach to the Continuous Dopaminergic Stimulation in Parkinson's Disease." The Israel Medical Association Journal : IMAJ, vol. 14, no. 3, 2012, pp. 175-9.
Schwartz M, Sabetay S. An approach to the continuous dopaminergic stimulation in Parkinson's disease. Isr Med Assoc J. 2012;14(3):175-9.
Schwartz, M., & Sabetay, S. (2012). An approach to the continuous dopaminergic stimulation in Parkinson's disease. The Israel Medical Association Journal : IMAJ, 14(3), 175-9.
Schwartz M, Sabetay S. An Approach to the Continuous Dopaminergic Stimulation in Parkinson's Disease. Isr Med Assoc J. 2012;14(3):175-9. PubMed PMID: 22675859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An approach to the continuous dopaminergic stimulation in Parkinson's disease. AU - Schwartz,Miguel, AU - Sabetay,Sergiu, PY - 2012/6/9/entrez PY - 2012/6/9/pubmed PY - 2012/7/11/medline SP - 175 EP - 9 JF - The Israel Medical Association journal : IMAJ JO - Isr Med Assoc J VL - 14 IS - 3 N2 - Dopaminergic neurons in the basal ganglia normally fire in a continuous manner, maintaining the striatal dopamine concentration at a relatively constant level. In Parkinson's disease, dopaminergic treatment produces a discontinuous stimulation, inducing an intermittent pulsatile activation of the striatal receptors. It is likely that the oscillations in the dopamine level in the striatum contribute to the development of motor complications. Treatment with long-acting dopaminergic agents, or providing a more continuous dopaminergic effect in the striatum, has been associated with fewer clinical motor complications. This review describes the state-of-the-art approach to achieve the desired continuous dopaminergic stimulation, providing patients with the best clinical effect and probably minimal motor complications. SN - 1565-1088 UR - https://www.unboundmedicine.com/medline/citation/22675859/An_approach_to_the_continuous_dopaminergic_stimulation_in_Parkinson's_disease_ L2 - http://www.ima.org.il/IMAJ/ViewArticle.aspx?year=2012&month=03&page=175 DB - PRIME DP - Unbound Medicine ER -