Tags

Type your tag names separated by a space and hit enter

Cardioprotection with 8-O-acetyl shanzhiside methylester on experimental myocardial ischemia injury.
Eur J Pharm Sci. 2012 Aug 30; 47(1):124-30.EJ

Abstract

8-O-acetyl shanzhiside methylester (ND01) was isolated from the leaves of Lamiophlomis rotata (Benth.) Kudo. In this study, we investigated the anti-myocardial ischemia and reperfusion (I/R) injury effects of ND01 in vivo and elucidated the potential mechanism in vitro. The results indicated that ND01 significantly attenuated hypoxia-induced cytotoxicity in a concentration-dependent manner in H9c2 cells. Treatment of H9c2 cells with ND01 9 μM blocked TNF-α-induced nuclear factor kappaB (NF-κB) phosphorylation by blocking High-mobility group box1 (HMGB1) expression. Treatment of rats with ND01 10mg/kg, (i.v.) protected the animals from myocardial I/R injury as indicated by a decrease in infarct volume, improvement in hemodynamics and reduction of myocardial damage severity. Treatment with ND01 also lowered serum levels of pro-inflammatory factors and reduced High mobility group box-1 protein (HMGB1) and phosphorylated NF-κB expression in ischemic myocardial tissue. Additionally, continuous i.v. of ND01 14 days attenuated cardiac remodeling. These protective effects suggested that ND01 might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.

Authors+Show Affiliations

School of Pharmaceutical Sciences, Binzhou Medical University, Yantai 264003, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22677812

Citation

Kang, Ze-Chun, et al. "Cardioprotection With 8-O-acetyl Shanzhiside Methylester On Experimental Myocardial Ischemia Injury." European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, vol. 47, no. 1, 2012, pp. 124-30.
Kang ZC, Jiang WL, Xu Y, et al. Cardioprotection with 8-O-acetyl shanzhiside methylester on experimental myocardial ischemia injury. Eur J Pharm Sci. 2012;47(1):124-30.
Kang, Z. C., Jiang, W. L., Xu, Y., Zhu, H. B., & Hou, J. (2012). Cardioprotection with 8-O-acetyl shanzhiside methylester on experimental myocardial ischemia injury. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 47(1), 124-30. https://doi.org/10.1016/j.ejps.2012.05.011
Kang ZC, et al. Cardioprotection With 8-O-acetyl Shanzhiside Methylester On Experimental Myocardial Ischemia Injury. Eur J Pharm Sci. 2012 Aug 30;47(1):124-30. PubMed PMID: 22677812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardioprotection with 8-O-acetyl shanzhiside methylester on experimental myocardial ischemia injury. AU - Kang,Ze-Chun, AU - Jiang,Wang-Lin, AU - Xu,Yong, AU - Zhu,Hai-Bo, AU - Hou,Jian, Y1 - 2012/06/05/ PY - 2012/01/31/received PY - 2012/05/03/revised PY - 2012/05/27/accepted PY - 2012/6/9/entrez PY - 2012/6/9/pubmed PY - 2013/3/9/medline SP - 124 EP - 30 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 47 IS - 1 N2 - 8-O-acetyl shanzhiside methylester (ND01) was isolated from the leaves of Lamiophlomis rotata (Benth.) Kudo. In this study, we investigated the anti-myocardial ischemia and reperfusion (I/R) injury effects of ND01 in vivo and elucidated the potential mechanism in vitro. The results indicated that ND01 significantly attenuated hypoxia-induced cytotoxicity in a concentration-dependent manner in H9c2 cells. Treatment of H9c2 cells with ND01 9 μM blocked TNF-α-induced nuclear factor kappaB (NF-κB) phosphorylation by blocking High-mobility group box1 (HMGB1) expression. Treatment of rats with ND01 10mg/kg, (i.v.) protected the animals from myocardial I/R injury as indicated by a decrease in infarct volume, improvement in hemodynamics and reduction of myocardial damage severity. Treatment with ND01 also lowered serum levels of pro-inflammatory factors and reduced High mobility group box-1 protein (HMGB1) and phosphorylated NF-κB expression in ischemic myocardial tissue. Additionally, continuous i.v. of ND01 14 days attenuated cardiac remodeling. These protective effects suggested that ND01 might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway. SN - 1879-0720 UR - https://www.unboundmedicine.com/medline/citation/22677812/Cardioprotection_with_8_O_acetyl_shanzhiside_methylester_on_experimental_myocardial_ischemia_injury_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-0987(12)00238-2 DB - PRIME DP - Unbound Medicine ER -