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Diarrhoea, weight loss and polyposis: think Cronkhite-Canada syndrome.
BMJ Case Rep. 2011 Sep 19; 2011BC

Abstract

A 71-year-old male presented with nausea, diarrhoea and weight loss. He had mild to moderate alopecia, paucity of eyebrow hair, erythematous non-pruritic nodular rash on the wrists, toenail onychomychosis and scalp hyperpigmentation. A colonoscopy revealed an irregular, haemorrhagic 5 cm rectosigmoid mass. Biopsies revealed mucin distended glands and focal ischemic changes. A CT scan showed numerous polypoid-like lesions in the stomach. Upper endoscopy showed mucosal erythema and nodularity with polypoid-like lesions. Biopsies showed cystic glandular dilatation, lamina propria oedema and chronic inflammation consistent with Cronkhite-Canada syndrome (CCS). The patient was started on nutrition supplementation. His skin manifestations were treated topically and with mineral supplements. He improved within 10 weeks and is currently asymptomatic. A high index of suspicion for CCS should exist in patients who present with weight loss, diarrhoea and polyposis. If diagnosed early, the disease can be treated with the goal of clinical remission.

Authors+Show Affiliations

Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, West Penn Allegheny Health System, Pittsburgh, Pennsylvania, United States. eaoun@wpahs.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22679262

Citation

Aoun, Elie, et al. "Diarrhoea, Weight Loss and Polyposis: Think Cronkhite-Canada Syndrome." BMJ Case Reports, vol. 2011, 2011.
Aoun E, Victain M, Mitre MC. Diarrhoea, weight loss and polyposis: think Cronkhite-Canada syndrome. BMJ Case Rep. 2011;2011.
Aoun, E., Victain, M., & Mitre, M. C. (2011). Diarrhoea, weight loss and polyposis: think Cronkhite-Canada syndrome. BMJ Case Reports, 2011. https://doi.org/10.1136/bcr.08.2011.4640
Aoun E, Victain M, Mitre MC. Diarrhoea, Weight Loss and Polyposis: Think Cronkhite-Canada Syndrome. BMJ Case Rep. 2011 Sep 19;2011 PubMed PMID: 22679262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diarrhoea, weight loss and polyposis: think Cronkhite-Canada syndrome. AU - Aoun,Elie, AU - Victain,Michelle, AU - Mitre,Marcia C, Y1 - 2011/09/19/ PY - 2012/6/9/entrez PY - 2011/1/1/pubmed PY - 2013/5/28/medline JF - BMJ case reports JO - BMJ Case Rep VL - 2011 N2 - A 71-year-old male presented with nausea, diarrhoea and weight loss. He had mild to moderate alopecia, paucity of eyebrow hair, erythematous non-pruritic nodular rash on the wrists, toenail onychomychosis and scalp hyperpigmentation. A colonoscopy revealed an irregular, haemorrhagic 5 cm rectosigmoid mass. Biopsies revealed mucin distended glands and focal ischemic changes. A CT scan showed numerous polypoid-like lesions in the stomach. Upper endoscopy showed mucosal erythema and nodularity with polypoid-like lesions. Biopsies showed cystic glandular dilatation, lamina propria oedema and chronic inflammation consistent with Cronkhite-Canada syndrome (CCS). The patient was started on nutrition supplementation. His skin manifestations were treated topically and with mineral supplements. He improved within 10 weeks and is currently asymptomatic. A high index of suspicion for CCS should exist in patients who present with weight loss, diarrhoea and polyposis. If diagnosed early, the disease can be treated with the goal of clinical remission. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/22679262/Diarrhoea_weight_loss_and_polyposis:_think_Cronkhite_Canada_syndrome_ L2 - https://casereports.bmj.com/cgi/pmidlookup?view=long&pmid=22679262 DB - PRIME DP - Unbound Medicine ER -