Tags

Type your tag names separated by a space and hit enter

"Artifactual" arsenate DNA.
Artif DNA PNA XNA. 2012 Jan-Mar; 3(1):1-2.AD

Abstract

The recent claim by Wolfe-Simon et al. that the Halomonas bacterial strain GFAJ-1 when grown in arsenate-containing medium with limiting phosphate is able to substitute phosphate with arsenate in biomolecules including nucleic acids and in particular DNA(1) arose much skepticism, primarily due to the very limited chemical stability of arsenate esters (see ref. 2 and references therein). A major part of the criticisms was concerned with the insufficient (bio)chemical evidence in the Wolfe-Simon study for the actual chemical incorporation of arsenate in DNA (and/or RNA). Redfield et al. now present evidence that the identification of arsenate DNA was artifactual.

Authors+Show Affiliations

Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ptrn@sund.ku.dk

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22679526

Citation

Nielsen, Peter E.. ""Artifactual" Arsenate DNA." Artificial DNA, PNA & XNA, vol. 3, no. 1, 2012, pp. 1-2.
Nielsen PE. "Artifactual" arsenate DNA. Artif DNA PNA XNA. 2012;3(1):1-2.
Nielsen, P. E. (2012). "Artifactual" arsenate DNA. Artificial DNA, PNA & XNA, 3(1), 1-2. https://doi.org/10.4161/adna.19672
Nielsen PE. "Artifactual" Arsenate DNA. Artif DNA PNA XNA. 2012 Jan-Mar;3(1):1-2. PubMed PMID: 22679526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - "Artifactual" arsenate DNA. A1 - Nielsen,Peter E, PY - 2012/6/9/entrez PY - 2012/6/9/pubmed PY - 2012/10/4/medline KW - DNA KW - arsenate KW - bacteria KW - genetic material KW - life SP - 1 EP - 2 JF - Artificial DNA, PNA & XNA JO - Artif DNA PNA XNA VL - 3 IS - 1 N2 - The recent claim by Wolfe-Simon et al. that the Halomonas bacterial strain GFAJ-1 when grown in arsenate-containing medium with limiting phosphate is able to substitute phosphate with arsenate in biomolecules including nucleic acids and in particular DNA(1) arose much skepticism, primarily due to the very limited chemical stability of arsenate esters (see ref. 2 and references therein). A major part of the criticisms was concerned with the insufficient (bio)chemical evidence in the Wolfe-Simon study for the actual chemical incorporation of arsenate in DNA (and/or RNA). Redfield et al. now present evidence that the identification of arsenate DNA was artifactual. SN - 1949-0968 UR - https://www.unboundmedicine.com/medline/citation/22679526/"Artifactual"_arsenate_DNA_ L2 - https://www.tandfonline.com/doi/full/10.4161/adna.19672 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.