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[Study of the correlation between the colorectal cancer Chinese medicine syndrome types and (excision repair cross-complementing 1, ERCC1) gene polymorphisms].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 May; 32(5):628-32.ZZ

Abstract

OBJECTIVE

To explore the correlation between excision repair cross-complementing 1 (ERCC1) C8092A and C19007T gene polymorphisms and different Chinese medicine (CM) syndrome types of colorectal cancer (CC).

METHODS

Ninety-nine patients with CC were syndrome typed as dampness-heat accumulation syndrome, qi stagnation with blood stasis syndrome, Pi-Shen yang deficiency syndrome, and Gan-Shen yin deficiency syndrome. The gene polymorphisms of excision repair cross-complementing 1 (ERCC1) C8092A and C19007T in different CM syndrome types of CC were examined by polymorphisms chain reaction amplification and direct sequencing, and analyzed statistically.

RESULTS

The frequencies of C8092A genotype and allele in different CM syndrome types had no statistical difference (P > 0.05). The frequencies of C19007T genotype and allele in different CM syndrome types had statistical difference (P < 0.05). Of them, there was no statistical difference in the frequencies between dampness-heat accumulation syndrome and qi stagnation with blood stasis syndrome, or between Pi-Shen yang deficiency syndrome and Gan-Shen yin deficiency syndrome (P > 0.05). There was statistical difference between dampness-heat accumulation syndrome and Pi-Shen yang deficiency syndrome as well as Gan-Shen yin deficiency syndrome (P < 0.05). There was statistical difference between qi stagnation with blood stasis syndrome and Pi-Shen yang deficiency syndrome as well as Gan-Shen yin deficiency syndrome (P < 0.05).

CONCLUSION

ERCC1 C19007T gene polymorphisms might be associated with CM syndrome types of CC, which needed to be further studied.

Links

clones/clone libraries

Authors+Show Affiliations

Cui TJ
Department of Tumor, Provincial Clinical College of Fujian Medical University, Fuzhou 350001. fjslctj@163.com
Chen YQ
No affiliation info available
Dai YM
No affiliation info available

MeSH

AdultAgedColorectal NeoplasmsDNA-Binding ProteinsEndonucleasesFemaleGenotypeHumansMaleMedicine, Chinese TraditionalMiddle AgedPolymorphism, GeneticYang DeficiencyYin Deficiency

Pub Type(s)

English Abstract
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

chi

PubMed ID

22679723

Citation

Cui, Tong-Jian, et al. "[Study of the Correlation Between the Colorectal Cancer Chinese Medicine Syndrome Types and (excision Repair Cross-complementing 1, ERCC1) Gene Polymorphisms]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 32, no. 5, 2012, pp. 628-32.
Cui TJ, Chen YQ, Dai YM. [Study of the correlation between the colorectal cancer Chinese medicine syndrome types and (excision repair cross-complementing 1, ERCC1) gene polymorphisms]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012;32(5):628-32.
Cui, T. J., Chen, Y. Q., & Dai, Y. M. (2012). [Study of the correlation between the colorectal cancer Chinese medicine syndrome types and (excision repair cross-complementing 1, ERCC1) gene polymorphisms]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 32(5), 628-32.
Cui TJ, Chen YQ, Dai YM. [Study of the Correlation Between the Colorectal Cancer Chinese Medicine Syndrome Types and (excision Repair Cross-complementing 1, ERCC1) Gene Polymorphisms]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012;32(5):628-32. PubMed PMID: 22679723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study of the correlation between the colorectal cancer Chinese medicine syndrome types and (excision repair cross-complementing 1, ERCC1) gene polymorphisms]. AU - Cui,Tong-Jian, AU - Chen,Yi-Qian, AU - Dai,Yong-Mei, PY - 2012/6/12/entrez PY - 2012/6/12/pubmed PY - 2014/1/3/medline SP - 628 EP - 32 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 32 IS - 5 N2 - OBJECTIVE: To explore the correlation between excision repair cross-complementing 1 (ERCC1) C8092A and C19007T gene polymorphisms and different Chinese medicine (CM) syndrome types of colorectal cancer (CC). METHODS: Ninety-nine patients with CC were syndrome typed as dampness-heat accumulation syndrome, qi stagnation with blood stasis syndrome, Pi-Shen yang deficiency syndrome, and Gan-Shen yin deficiency syndrome. The gene polymorphisms of excision repair cross-complementing 1 (ERCC1) C8092A and C19007T in different CM syndrome types of CC were examined by polymorphisms chain reaction amplification and direct sequencing, and analyzed statistically. RESULTS: The frequencies of C8092A genotype and allele in different CM syndrome types had no statistical difference (P > 0.05). The frequencies of C19007T genotype and allele in different CM syndrome types had statistical difference (P < 0.05). Of them, there was no statistical difference in the frequencies between dampness-heat accumulation syndrome and qi stagnation with blood stasis syndrome, or between Pi-Shen yang deficiency syndrome and Gan-Shen yin deficiency syndrome (P > 0.05). There was statistical difference between dampness-heat accumulation syndrome and Pi-Shen yang deficiency syndrome as well as Gan-Shen yin deficiency syndrome (P < 0.05). There was statistical difference between qi stagnation with blood stasis syndrome and Pi-Shen yang deficiency syndrome as well as Gan-Shen yin deficiency syndrome (P < 0.05). CONCLUSION: ERCC1 C19007T gene polymorphisms might be associated with CM syndrome types of CC, which needed to be further studied. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/22679723/[Study_of_the_correlation_between_the_colorectal_cancer_Chinese_medicine_syndrome_types_and__excision_repair_cross_complementing_1_ERCC1__gene_polymorphisms]_ L2 - http://www.diseaseinfosearch.org/result/8005 DB - PRIME DP - Unbound Medicine ER -