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Estradiol acutely suppresses inhibition in the hippocampus through a sex-specific endocannabinoid and mGluR-dependent mechanism.
Neuron. 2012 Jun 07; 74(5):801-8.N

Abstract

The steroid 17β-estradiol (E2) is well known to influence hippocampal functions such as memory, affective behaviors, and epilepsy. There is growing awareness that in addition to responding to ovarian E2, the hippocampus of both males and females synthesizes E2 as a neurosteroid that could acutely modulate synaptic function. Previous work on acute E2 actions in the hippocampus has focused on excitatory synapses. Here, we show that E2 rapidly suppresses inhibitory synaptic transmission in hippocampal CA1. E2 acts through the α form of the estrogen receptor to stimulate postsynaptic mGluR1-dependent mobilization of the endocannabinoid anandamide, which retrogradely suppresses GABA release from CB1 receptor-containing inhibitory presynaptic boutons. Remarkably, this effect of E2 is sex specific, occurring in females but not in males. Acute E2 modulation of endocannabinoid tone and consequent suppression of inhibition provide a mechanism by which neurosteroid E2 could modulate hippocampus-dependent behaviors in a sex-specific manner.

Authors+Show Affiliations

Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22681685

Citation

Huang, Guang Zhe, and Catherine S. Woolley. "Estradiol Acutely Suppresses Inhibition in the Hippocampus Through a Sex-specific Endocannabinoid and mGluR-dependent Mechanism." Neuron, vol. 74, no. 5, 2012, pp. 801-8.
Huang GZ, Woolley CS. Estradiol acutely suppresses inhibition in the hippocampus through a sex-specific endocannabinoid and mGluR-dependent mechanism. Neuron. 2012;74(5):801-8.
Huang, G. Z., & Woolley, C. S. (2012). Estradiol acutely suppresses inhibition in the hippocampus through a sex-specific endocannabinoid and mGluR-dependent mechanism. Neuron, 74(5), 801-8. https://doi.org/10.1016/j.neuron.2012.03.035
Huang GZ, Woolley CS. Estradiol Acutely Suppresses Inhibition in the Hippocampus Through a Sex-specific Endocannabinoid and mGluR-dependent Mechanism. Neuron. 2012 Jun 7;74(5):801-8. PubMed PMID: 22681685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estradiol acutely suppresses inhibition in the hippocampus through a sex-specific endocannabinoid and mGluR-dependent mechanism. AU - Huang,Guang Zhe, AU - Woolley,Catherine S, PY - 2012/03/19/accepted PY - 2012/6/12/entrez PY - 2012/6/12/pubmed PY - 2012/8/18/medline SP - 801 EP - 8 JF - Neuron JO - Neuron VL - 74 IS - 5 N2 - The steroid 17β-estradiol (E2) is well known to influence hippocampal functions such as memory, affective behaviors, and epilepsy. There is growing awareness that in addition to responding to ovarian E2, the hippocampus of both males and females synthesizes E2 as a neurosteroid that could acutely modulate synaptic function. Previous work on acute E2 actions in the hippocampus has focused on excitatory synapses. Here, we show that E2 rapidly suppresses inhibitory synaptic transmission in hippocampal CA1. E2 acts through the α form of the estrogen receptor to stimulate postsynaptic mGluR1-dependent mobilization of the endocannabinoid anandamide, which retrogradely suppresses GABA release from CB1 receptor-containing inhibitory presynaptic boutons. Remarkably, this effect of E2 is sex specific, occurring in females but not in males. Acute E2 modulation of endocannabinoid tone and consequent suppression of inhibition provide a mechanism by which neurosteroid E2 could modulate hippocampus-dependent behaviors in a sex-specific manner. SN - 1097-4199 UR - https://www.unboundmedicine.com/medline/citation/22681685/Estradiol_acutely_suppresses_inhibition_in_the_hippocampus_through_a_sex_specific_endocannabinoid_and_mGluR_dependent_mechanism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(12)00375-3 DB - PRIME DP - Unbound Medicine ER -