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[Effects of cyproheptadine on the electrophysiological characteristics of the sinus node, ventricular myocytes and papillary muscles of the guinea pig heart].
Arch Inst Cardiol Mex. 1990 Jul-Aug; 60(4):361-8.AI

Abstract

Cyproheptadine is an antagonist of S1 serotoninergic and H1 histaminergic receptors, with a well known cardiovascular activity, mainly vasodilation and a negative chronotropic effect. It has been suggested that cyproheptadine as other antiserotoninergic drugs act by blocking the calcium channel. In order to explore this possibility the actions of this drug were studied in several cardiac preparations: sinus node, isolated ventricular myocytes and papillary muscle from guinea-pig's heart. The experiments were performed using the conventional recording techniques of intracellular electrical activity and isometric tension. Doses from 0.25 microM to 1.0 microM were studied. The main findings were: in sinus node: a) inhibition of automatic activity, b) a decrease in the upstroke, c) a decrease in the plateau level, and d) a shortening of the action potential. In isolated ventricular myocytes: a) a decrease in the rate of depolarization, b) a decrease in the plateau level and c) a shortening of the action potential. In the papillary muscle: a) a decrease in tension and b) a shortening of the action potential. All the effects observed were dose dependent an agree with a blockade of the calcium channel.

Authors+Show Affiliations

Santillán A
Departamento de Fisiología del Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
Almanza J
No affiliation info available
Valenzuela F
No affiliation info available

MeSH

Action PotentialsAnimalsCyproheptadineElectrophysiologyGuinea PigsHeartHeart RateHeart VentriclesIn Vitro TechniquesMyocardial ContractionMyocardiumPapillary MusclesReceptors, Histamine H1Receptors, SerotoninSinoatrial Node

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

2268173

Citation

Santillán, A, et al. "[Effects of Cyproheptadine On the Electrophysiological Characteristics of the Sinus Node, Ventricular Myocytes and Papillary Muscles of the Guinea Pig Heart]." Archivos Del Instituto De Cardiologia De Mexico, vol. 60, no. 4, 1990, pp. 361-8.
Santillán A, Almanza J, Valenzuela F. [Effects of cyproheptadine on the electrophysiological characteristics of the sinus node, ventricular myocytes and papillary muscles of the guinea pig heart]. Arch Inst Cardiol Mex. 1990;60(4):361-8.
Santillán, A., Almanza, J., & Valenzuela, F. (1990). [Effects of cyproheptadine on the electrophysiological characteristics of the sinus node, ventricular myocytes and papillary muscles of the guinea pig heart]. Archivos Del Instituto De Cardiologia De Mexico, 60(4), 361-8.
Santillán A, Almanza J, Valenzuela F. [Effects of Cyproheptadine On the Electrophysiological Characteristics of the Sinus Node, Ventricular Myocytes and Papillary Muscles of the Guinea Pig Heart]. Arch Inst Cardiol Mex. 1990 Jul-Aug;60(4):361-8. PubMed PMID: 2268173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of cyproheptadine on the electrophysiological characteristics of the sinus node, ventricular myocytes and papillary muscles of the guinea pig heart]. AU - Santillán,A, AU - Almanza,J, AU - Valenzuela,F, PY - 1990/7/1/pubmed PY - 1990/7/1/medline PY - 1990/7/1/entrez SP - 361 EP - 8 JF - Archivos del Instituto de Cardiologia de Mexico JO - Arch Inst Cardiol Mex VL - 60 IS - 4 N2 - Cyproheptadine is an antagonist of S1 serotoninergic and H1 histaminergic receptors, with a well known cardiovascular activity, mainly vasodilation and a negative chronotropic effect. It has been suggested that cyproheptadine as other antiserotoninergic drugs act by blocking the calcium channel. In order to explore this possibility the actions of this drug were studied in several cardiac preparations: sinus node, isolated ventricular myocytes and papillary muscle from guinea-pig's heart. The experiments were performed using the conventional recording techniques of intracellular electrical activity and isometric tension. Doses from 0.25 microM to 1.0 microM were studied. The main findings were: in sinus node: a) inhibition of automatic activity, b) a decrease in the upstroke, c) a decrease in the plateau level, and d) a shortening of the action potential. In isolated ventricular myocytes: a) a decrease in the rate of depolarization, b) a decrease in the plateau level and c) a shortening of the action potential. In the papillary muscle: a) a decrease in tension and b) a shortening of the action potential. All the effects observed were dose dependent an agree with a blockade of the calcium channel. SN - 0020-3785 UR - https://www.unboundmedicine.com/medline/citation/2268173/[Effects_of_cyproheptadine_on_the_electrophysiological_characteristics_of_the_sinus_node_ventricular_myocytes_and_papillary_muscles_of_the_guinea_pig_heart]_ DB - PRIME DP - Unbound Medicine ER -