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Fish consumption, omega-3 fatty acids and risk of heart failure: a meta-analysis.

Abstract

BACKGROUND & AIMS

While marine omega-3 fatty acids have been associated with a lower mortality in heart failure patients, data on omega-3 and incident heart failure are inconsistent. We systematically reviewed the evidence on the association of omega-3 fatty acids and fish intake with the incidence of heart failure in this meta-analysis.

METHODS

We identified relevant studies by searching MEDLINE and EMBASE databases up to August 31, 2011 without restrictions and by reviewing reference lists from retrieved articles.

RESULTS

A total of 176,441 subjects and 5480 incident cases of heart failure from 7 prospective studies were included in this analysis. Using random effect model, the pooled relative risk for heart failure comparing the highest to lowest category of fish intake was 0.85 (95% CI; 0.73-0.99), p = 0.04; corresponding value for marine omega-3 fatty acids was 0.86 (0.74-1.00), p = 0.05. There was no evidence for heterogeneity across studies of fish consumption (I(2) = 8%). In contrast, there was modest heterogeneity for omega-3 fatty acid analysis (I(2) = 44%). Lastly, there was no evidence for publication bias.

CONCLUSIONS

This meta-analysis is consistent with a lower risk of heart failure with intake of marine omega-3 fatty acids. These observational findings should be confirmed in a large randomized trial.

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  • Authors+Show Affiliations

    ,

    Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02120, USA. ldjousse@rics.bwh.harvard.edu

    , , ,

    Source

    MeSH

    Animals
    Fatty Acids, Omega-3
    Fishes
    Heart Failure
    Humans
    Incidence
    Risk Factors
    Seafood

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    22682084

    Citation

    Djoussé, Luc, et al. "Fish Consumption, Omega-3 Fatty Acids and Risk of Heart Failure: a Meta-analysis." Clinical Nutrition (Edinburgh, Scotland), vol. 31, no. 6, 2012, pp. 846-53.
    Djoussé L, Akinkuolie AO, Wu JH, et al. Fish consumption, omega-3 fatty acids and risk of heart failure: a meta-analysis. Clin Nutr. 2012;31(6):846-53.
    Djoussé, L., Akinkuolie, A. O., Wu, J. H., Ding, E. L., & Gaziano, J. M. (2012). Fish consumption, omega-3 fatty acids and risk of heart failure: a meta-analysis. Clinical Nutrition (Edinburgh, Scotland), 31(6), pp. 846-53. doi:10.1016/j.clnu.2012.05.010.
    Djoussé L, et al. Fish Consumption, Omega-3 Fatty Acids and Risk of Heart Failure: a Meta-analysis. Clin Nutr. 2012;31(6):846-53. PubMed PMID: 22682084.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fish consumption, omega-3 fatty acids and risk of heart failure: a meta-analysis. AU - Djoussé,Luc, AU - Akinkuolie,Akintunde O, AU - Wu,Jason H Y, AU - Ding,Eric L, AU - Gaziano,J Michael, Y1 - 2012/06/06/ PY - 2012/04/06/received PY - 2012/05/02/revised PY - 2012/05/10/accepted PY - 2012/6/12/entrez PY - 2012/6/12/pubmed PY - 2013/5/10/medline SP - 846 EP - 53 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 31 IS - 6 N2 - BACKGROUND & AIMS: While marine omega-3 fatty acids have been associated with a lower mortality in heart failure patients, data on omega-3 and incident heart failure are inconsistent. We systematically reviewed the evidence on the association of omega-3 fatty acids and fish intake with the incidence of heart failure in this meta-analysis. METHODS: We identified relevant studies by searching MEDLINE and EMBASE databases up to August 31, 2011 without restrictions and by reviewing reference lists from retrieved articles. RESULTS: A total of 176,441 subjects and 5480 incident cases of heart failure from 7 prospective studies were included in this analysis. Using random effect model, the pooled relative risk for heart failure comparing the highest to lowest category of fish intake was 0.85 (95% CI; 0.73-0.99), p = 0.04; corresponding value for marine omega-3 fatty acids was 0.86 (0.74-1.00), p = 0.05. There was no evidence for heterogeneity across studies of fish consumption (I(2) = 8%). In contrast, there was modest heterogeneity for omega-3 fatty acid analysis (I(2) = 44%). Lastly, there was no evidence for publication bias. CONCLUSIONS: This meta-analysis is consistent with a lower risk of heart failure with intake of marine omega-3 fatty acids. These observational findings should be confirmed in a large randomized trial. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/22682084/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(12)00110-0 DB - PRIME DP - Unbound Medicine ER -