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Genomic imbalances in benign metastasizing leiomyoma: characterization by conventional karyotypic, fluorescence in situ hybridization, and whole genome SNP array analysis.
Cancer Genet. 2012 May; 205(5):249-54.CG

Abstract

Benign metastasizing leiomyoma, a rare condition of controversial origin, is characterized by the occurrence of extrauterine smooth muscle tumors primarily affecting the lungs of women with a history of uterine leiomyomas. Numerous genetic studies of uterine leiomyoma with rearrangements of the HMGA2 and HMGA1 loci defined in prominent subgroups have been conducted. In contrast, cytogenetic and molecular descriptions of benign metastasizing leiomyoma are few, and, in particular, this entity has not been previously subjected to single nucleotide polymorphism (SNP) array analysis. In this study, conventional karyotypic, and/or molecular cytogenetic, and SNP array characterization of a pleuropulmonary benign mestasizing leiomyoma and a synchronous deep soft tissue leiomyoma of the thigh, which arose in a 56-year-old female with a remote history of uterine leiomyomata, revealed rearrangement of the HMGA1 (6p21) locus and nearly identical genomic profiles, including loss of chromosome 7 material in both lesions. These findings suggest that both the deep soft tissue and pleuropulmonary lesions were derived from the same abnormal clone and are genetically related to uterine leiomyomata.

Authors+Show Affiliations

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22682624

Citation

Bowen, Joslin M., et al. "Genomic Imbalances in Benign Metastasizing Leiomyoma: Characterization By Conventional Karyotypic, Fluorescence in Situ Hybridization, and Whole Genome SNP Array Analysis." Cancer Genetics, vol. 205, no. 5, 2012, pp. 249-54.
Bowen JM, Cates JM, Kash S, et al. Genomic imbalances in benign metastasizing leiomyoma: characterization by conventional karyotypic, fluorescence in situ hybridization, and whole genome SNP array analysis. Cancer Genet. 2012;205(5):249-54.
Bowen, J. M., Cates, J. M., Kash, S., Itani, D., Gonzalez, A., Huang, D., Oliveira, A., & Bridge, J. A. (2012). Genomic imbalances in benign metastasizing leiomyoma: characterization by conventional karyotypic, fluorescence in situ hybridization, and whole genome SNP array analysis. Cancer Genetics, 205(5), 249-54. https://doi.org/10.1016/j.cancergen.2012.04.005
Bowen JM, et al. Genomic Imbalances in Benign Metastasizing Leiomyoma: Characterization By Conventional Karyotypic, Fluorescence in Situ Hybridization, and Whole Genome SNP Array Analysis. Cancer Genet. 2012;205(5):249-54. PubMed PMID: 22682624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genomic imbalances in benign metastasizing leiomyoma: characterization by conventional karyotypic, fluorescence in situ hybridization, and whole genome SNP array analysis. AU - Bowen,Joslin M, AU - Cates,Justin M, AU - Kash,Shera, AU - Itani,Doha, AU - Gonzalez,Adriana, AU - Huang,Dali, AU - Oliveira,Andre, AU - Bridge,Julia A, PY - 2012/01/30/received PY - 2012/04/09/revised PY - 2012/04/14/accepted PY - 2012/6/12/entrez PY - 2012/6/12/pubmed PY - 2012/8/29/medline SP - 249 EP - 54 JF - Cancer genetics JO - Cancer Genet VL - 205 IS - 5 N2 - Benign metastasizing leiomyoma, a rare condition of controversial origin, is characterized by the occurrence of extrauterine smooth muscle tumors primarily affecting the lungs of women with a history of uterine leiomyomas. Numerous genetic studies of uterine leiomyoma with rearrangements of the HMGA2 and HMGA1 loci defined in prominent subgroups have been conducted. In contrast, cytogenetic and molecular descriptions of benign metastasizing leiomyoma are few, and, in particular, this entity has not been previously subjected to single nucleotide polymorphism (SNP) array analysis. In this study, conventional karyotypic, and/or molecular cytogenetic, and SNP array characterization of a pleuropulmonary benign mestasizing leiomyoma and a synchronous deep soft tissue leiomyoma of the thigh, which arose in a 56-year-old female with a remote history of uterine leiomyomata, revealed rearrangement of the HMGA1 (6p21) locus and nearly identical genomic profiles, including loss of chromosome 7 material in both lesions. These findings suggest that both the deep soft tissue and pleuropulmonary lesions were derived from the same abnormal clone and are genetically related to uterine leiomyomata. SN - 2210-7762 UR - https://www.unboundmedicine.com/medline/citation/22682624/Genomic_imbalances_in_benign_metastasizing_leiomyoma:_characterization_by_conventional_karyotypic_fluorescence_in_situ_hybridization_and_whole_genome_SNP_array_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2210-7762(12)00119-6 DB - PRIME DP - Unbound Medicine ER -