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Preoperative peripheral blood human telomerase reverse transcriptase mRNA concentration is not a prognostic factor for resection of hepatocellular carcinoma.
Hepatogastroenterology. 2012 Jul-Aug; 59(117):1512-5.H

Abstract

BACKGROUND/AIMS

Hepatocellular carcinoma (HCC) often recurs after complete surgical resection. Detection of markers of residual circulating cancer cells may predict postoperative HCC recurrence. Human telomerase reverse transcriptase (hTERT) mRNA may be a candidate tumor marker.

METHODOLOGY

We prospectively assessed the expression patterns and prognostic value of preoperative peripheral blood hTERT mRNA in patients with HCC undergoing hepatic resection (n=17) or liver transplantation (n=6). As controls, we assessed hTERT mRNA in patients with liver cirrhosis without HCC (n=6) and in living liver donors (n=4). Concentrations of hTERT mRNA were measured by real-time quantitative reverse transcription polymerase chain reaction (RTPCR).

RESULTS

No significant difference was observed in the levels of hTERT mRNA between the HCC and control groups. Only alpha-fetoprotein ≥400ng/mL was associated with greater expression levels of hTERT mRNA. At a median follow-up of 30 months, HCC recurred in 10 of 17 resected patients, but in none of the 6 liver transplant recipients. hTERT mRNA concentration was not associated with HCC recurrence after either resection or liver transplantation.

CONCLUSIONS

Peripheral blood hTERT mRNA concentration is not a likely marker for the diagnosis or prognosis of HCC, especially in patients undergoing resection. Owing to the small number of transplanted patients assessed, the clinical significance of hTERT mRNA concentration was not objectively verified, suggesting the need for a study in larger numbers of HCC patients undergoing liver transplantation.

Authors+Show Affiliations

Department of Surgery, University of Ulsan College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22683968

Citation

Kim, Yeon-Dae, et al. "Preoperative Peripheral Blood Human Telomerase Reverse Transcriptase mRNA Concentration Is Not a Prognostic Factor for Resection of Hepatocellular Carcinoma." Hepato-gastroenterology, vol. 59, no. 117, 2012, pp. 1512-5.
Kim YD, Hwang S, Lee YJ, et al. Preoperative peripheral blood human telomerase reverse transcriptase mRNA concentration is not a prognostic factor for resection of hepatocellular carcinoma. Hepatogastroenterology. 2012;59(117):1512-5.
Kim, Y. D., Hwang, S., Lee, Y. J., Kim, K. H., Ahn, C. S., Park, K. M., Moon, D. B., Ha, T. Y., Song, G. W., Jung, D. H., Park, S. R., Hong, H. N., & Lee, S. G. (2012). Preoperative peripheral blood human telomerase reverse transcriptase mRNA concentration is not a prognostic factor for resection of hepatocellular carcinoma. Hepato-gastroenterology, 59(117), 1512-5. https://doi.org/10.5754/hge10342
Kim YD, et al. Preoperative Peripheral Blood Human Telomerase Reverse Transcriptase mRNA Concentration Is Not a Prognostic Factor for Resection of Hepatocellular Carcinoma. Hepatogastroenterology. 2012 Jul-Aug;59(117):1512-5. PubMed PMID: 22683968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preoperative peripheral blood human telomerase reverse transcriptase mRNA concentration is not a prognostic factor for resection of hepatocellular carcinoma. AU - Kim,Yeon-Dae, AU - Hwang,Shin, AU - Lee,Young-Joo, AU - Kim,Ki-Hun, AU - Ahn,Chul-Soo, AU - Park,Kwang-Min, AU - Moon,Deok-Bog, AU - Ha,Tae-Yong, AU - Song,Gi-Won, AU - Jung,Dong-Hwan, AU - Park,Se-Ra, AU - Hong,Hea-Nam, AU - Lee,Sung-Gyu, PY - 2012/6/12/entrez PY - 2012/6/12/pubmed PY - 2012/10/19/medline SP - 1512 EP - 5 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 59 IS - 117 N2 - BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) often recurs after complete surgical resection. Detection of markers of residual circulating cancer cells may predict postoperative HCC recurrence. Human telomerase reverse transcriptase (hTERT) mRNA may be a candidate tumor marker. METHODOLOGY: We prospectively assessed the expression patterns and prognostic value of preoperative peripheral blood hTERT mRNA in patients with HCC undergoing hepatic resection (n=17) or liver transplantation (n=6). As controls, we assessed hTERT mRNA in patients with liver cirrhosis without HCC (n=6) and in living liver donors (n=4). Concentrations of hTERT mRNA were measured by real-time quantitative reverse transcription polymerase chain reaction (RTPCR). RESULTS: No significant difference was observed in the levels of hTERT mRNA between the HCC and control groups. Only alpha-fetoprotein ≥400ng/mL was associated with greater expression levels of hTERT mRNA. At a median follow-up of 30 months, HCC recurred in 10 of 17 resected patients, but in none of the 6 liver transplant recipients. hTERT mRNA concentration was not associated with HCC recurrence after either resection or liver transplantation. CONCLUSIONS: Peripheral blood hTERT mRNA concentration is not a likely marker for the diagnosis or prognosis of HCC, especially in patients undergoing resection. Owing to the small number of transplanted patients assessed, the clinical significance of hTERT mRNA concentration was not objectively verified, suggesting the need for a study in larger numbers of HCC patients undergoing liver transplantation. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/22683968/Preoperative_peripheral_blood_human_telomerase_reverse_transcriptase_mRNA_concentration_is_not_a_prognostic_factor_for_resection_of_hepatocellular_carcinoma_ L2 - https://medlineplus.gov/livercancer.html DB - PRIME DP - Unbound Medicine ER -