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The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia.
Int Psychogeriatr. 2012 Nov; 24(11):1749-55.IP

Abstract

BACKGROUND

To examine the discriminant validity of the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE) in detecting patients with cognitive impairment at higher risk for dementia at a memory clinic setting.

METHODS

Memory clinic patients were administered the MoCA, MMSE, and a comprehensive formal neuropsychological battery. Mild cognitive impairment (MCI) subtypes were dichotomized into two groups: single domain-MCI (sd-MCI) and multiple domain-MCI (md-MCI). Area under the receiver operating characteristic curve (ROC) analysis was used to compare the discriminatory ability of the MoCA and the MMSE.

RESULTS

Two hundred thirty patients were recruited, of which 136 (59.1%) were diagnosed with dementia, 61 (26.5%) with MCI, and 33 (14.3%) with no cognitive impairment (NCI). The majority of MCI patients had md-MCI (n = 36, 59%). The MoCA had significantly larger AUCs than the MMSE in discriminating md-MCI from the lower risk group for incident dementia (NCI and sd-MCI) [MoCA 0.92 (95% CI, 0.86-0.98) vs. MMSE 0.84 (95% CI, 0.75-0.92), p = 0.02). At their optimal cut-off points, the MoCA (19/20) remained superior to the MMSE (23/24) in detecting md-MCI [sensitivity: 0.83 vs. 0.72; specificity: 0.86 vs. 0.83; PPV: 0.79 vs. 0.72; NPV: 0.89 vs. 0.83; correctly classified: 85.1% vs. 78.7%].

CONCLUSION

The MoCA is superior to the MMSE in the detection of patients with cognitive impairment at higher risk for incident dementia at a memory clinic setting.

Authors+Show Affiliations

Department of Pharmacology, National University Health System, Clinical Research Centre, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22687278

Citation

Dong, YanHong, et al. "The Montreal Cognitive Assessment Is Superior to the Mini-Mental State Examination in Detecting Patients at Higher Risk of Dementia." International Psychogeriatrics, vol. 24, no. 11, 2012, pp. 1749-55.
Dong Y, Lee WY, Basri NA, et al. The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia. Int Psychogeriatr. 2012;24(11):1749-55.
Dong, Y., Lee, W. Y., Basri, N. A., Collinson, S. L., Merchant, R. A., Venketasubramanian, N., & Chen, C. L. (2012). The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia. International Psychogeriatrics, 24(11), 1749-55. https://doi.org/10.1017/S1041610212001068
Dong Y, et al. The Montreal Cognitive Assessment Is Superior to the Mini-Mental State Examination in Detecting Patients at Higher Risk of Dementia. Int Psychogeriatr. 2012;24(11):1749-55. PubMed PMID: 22687278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia. AU - Dong,YanHong, AU - Lee,Wah Yean, AU - Basri,Nur Adilah, AU - Collinson,Simon Lowes, AU - Merchant,Reshma A, AU - Venketasubramanian,Narayanaswamy, AU - Chen,Christopher Li-Hsian, Y1 - 2012/06/12/ PY - 2012/6/13/entrez PY - 2012/6/13/pubmed PY - 2013/2/13/medline SP - 1749 EP - 55 JF - International psychogeriatrics JO - Int Psychogeriatr VL - 24 IS - 11 N2 - BACKGROUND: To examine the discriminant validity of the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE) in detecting patients with cognitive impairment at higher risk for dementia at a memory clinic setting. METHODS: Memory clinic patients were administered the MoCA, MMSE, and a comprehensive formal neuropsychological battery. Mild cognitive impairment (MCI) subtypes were dichotomized into two groups: single domain-MCI (sd-MCI) and multiple domain-MCI (md-MCI). Area under the receiver operating characteristic curve (ROC) analysis was used to compare the discriminatory ability of the MoCA and the MMSE. RESULTS: Two hundred thirty patients were recruited, of which 136 (59.1%) were diagnosed with dementia, 61 (26.5%) with MCI, and 33 (14.3%) with no cognitive impairment (NCI). The majority of MCI patients had md-MCI (n = 36, 59%). The MoCA had significantly larger AUCs than the MMSE in discriminating md-MCI from the lower risk group for incident dementia (NCI and sd-MCI) [MoCA 0.92 (95% CI, 0.86-0.98) vs. MMSE 0.84 (95% CI, 0.75-0.92), p = 0.02). At their optimal cut-off points, the MoCA (19/20) remained superior to the MMSE (23/24) in detecting md-MCI [sensitivity: 0.83 vs. 0.72; specificity: 0.86 vs. 0.83; PPV: 0.79 vs. 0.72; NPV: 0.89 vs. 0.83; correctly classified: 85.1% vs. 78.7%]. CONCLUSION: The MoCA is superior to the MMSE in the detection of patients with cognitive impairment at higher risk for incident dementia at a memory clinic setting. SN - 1741-203X UR - https://www.unboundmedicine.com/medline/citation/22687278/The_Montreal_Cognitive_Assessment_is_superior_to_the_Mini_Mental_State_Examination_in_detecting_patients_at_higher_risk_of_dementia_ L2 - https://www.cambridge.org/core/product/identifier/S1041610212001068/type/journal_article DB - PRIME DP - Unbound Medicine ER -