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Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate.
Adv Anat Pathol. 2012 Jul; 19(4):270-8.AA

Abstract

Atypical cribriform lesions of the prostate gland consist of cribriform and rarely solid proliferation of prostate glands populated with cytologically atypical cells with partial or complete basal cell lining. It may represent cribriform "high-grade prostatic intraepithelial neoplasia" (HGPIN) or "intraductal carcinoma of the prostate" (IDC-P). IDC-P is almost always associated with clinically aggressive and high-volume prostate carcinoma. In contrast, cribriform HGPIN is a putative neoplastic precursor lesion, and recent data have questioned whether HGPIN on needle biopsy is associated with a significantly increased cancer risk in subsequent biopsies, and whether the diagnosis mandates rebiopsy within the first year after its diagnosis. As the result, the distinction between these 2 lesions has profound clinical implications, especially on needle biopsies. Since its original description, several studies have attempted to further refine histologic definition of IDC-P in the past decade. Even though presence of certain morphologic features (eg, pleomorphic nuclei or nuclei 6× the size of adjacent nuclei, intraluminal necrosis, and dense cribriform and solid architecture) are seen only in IDC-P, IDC-P may also exhibit "low-grade" morphologic features that overlap with cribriform HGPIN. Emerging molecular data on TMPRSS:ERG gene fusions further support the fact that these 2 lesions are biologically distinct. IDC-P is an uncommon finding in prostate biopsies; however, patients with IDC-P as sole findings without concomitant prostate carcinoma in biopsy are recommended for either definitive treatment or immediate repeat biopsy. This article summarizes the morphologic and molecular characteristics of IDC-P and cribriform HGPIN and an approach to work-up of atypical cribriform lesions in prostate needle biopsies.

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Authors+Show Affiliations

Shah RB
Division of Urologic Pathology, Miraca Research Institute, Miraca Life Sciences, Irving, TX, USA.
Zhou M
No affiliation info available

MeSH

Biopsy, NeedleCarcinoma, DuctalColorectal NeoplasmsHumansMaleProstateProstatic Intraepithelial NeoplasiaProstatic NeoplasmsSerine EndopeptidasesUrothelium

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22692290

Citation

Shah, Rajal B., and Ming Zhou. "Atypical Cribriform Lesions of the Prostate: Clinical Significance, Differential Diagnosis and Current Concept of Intraductal Carcinoma of the Prostate." Advances in Anatomic Pathology, vol. 19, no. 4, 2012, pp. 270-8.
Shah RB, Zhou M. Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. Adv Anat Pathol. 2012;19(4):270-8.
Shah, R. B., & Zhou, M. (2012). Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. Advances in Anatomic Pathology, 19(4), 270-8. https://doi.org/10.1097/PAP.0b013e31825c6c0e
Shah RB, Zhou M. Atypical Cribriform Lesions of the Prostate: Clinical Significance, Differential Diagnosis and Current Concept of Intraductal Carcinoma of the Prostate. Adv Anat Pathol. 2012;19(4):270-8. PubMed PMID: 22692290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. AU - Shah,Rajal B, AU - Zhou,Ming, PY - 2012/6/14/entrez PY - 2012/6/14/pubmed PY - 2012/10/16/medline SP - 270 EP - 8 JF - Advances in anatomic pathology JO - Adv Anat Pathol VL - 19 IS - 4 N2 - Atypical cribriform lesions of the prostate gland consist of cribriform and rarely solid proliferation of prostate glands populated with cytologically atypical cells with partial or complete basal cell lining. It may represent cribriform "high-grade prostatic intraepithelial neoplasia" (HGPIN) or "intraductal carcinoma of the prostate" (IDC-P). IDC-P is almost always associated with clinically aggressive and high-volume prostate carcinoma. In contrast, cribriform HGPIN is a putative neoplastic precursor lesion, and recent data have questioned whether HGPIN on needle biopsy is associated with a significantly increased cancer risk in subsequent biopsies, and whether the diagnosis mandates rebiopsy within the first year after its diagnosis. As the result, the distinction between these 2 lesions has profound clinical implications, especially on needle biopsies. Since its original description, several studies have attempted to further refine histologic definition of IDC-P in the past decade. Even though presence of certain morphologic features (eg, pleomorphic nuclei or nuclei 6× the size of adjacent nuclei, intraluminal necrosis, and dense cribriform and solid architecture) are seen only in IDC-P, IDC-P may also exhibit "low-grade" morphologic features that overlap with cribriform HGPIN. Emerging molecular data on TMPRSS:ERG gene fusions further support the fact that these 2 lesions are biologically distinct. IDC-P is an uncommon finding in prostate biopsies; however, patients with IDC-P as sole findings without concomitant prostate carcinoma in biopsy are recommended for either definitive treatment or immediate repeat biopsy. This article summarizes the morphologic and molecular characteristics of IDC-P and cribriform HGPIN and an approach to work-up of atypical cribriform lesions in prostate needle biopsies. SN - 1533-4031 UR - https://www.unboundmedicine.com/medline/citation/22692290/Atypical_cribriform_lesions_of_the_prostate:_clinical_significance_differential_diagnosis_and_current_concept_of_intraductal_carcinoma_of_the_prostate_ L2 - https://doi.org/10.1097/PAP.0b013e31825c6c0e DB - PRIME DP - Unbound Medicine ER -