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Coffee consumption and prostate cancer risk: further evidence for inverse relationship.
Nutr J 2012; 11:42NJ

Abstract

BACKGROUND

Higher consumption of coffee intake has recently been linked with reduced risk of aggressive prostate cancer (PC) incidence, although meta-analysis of other studies that examine the association between coffee consumption and overall PC risk remains inconclusive. Only one recent study investigated the association between coffee intake and grade-specific incidence of PC, further evidence is required to understand the aetiology of aggressive PCs. Therefore, we conducted a prospective study to examine the relationship between coffee intake and overall as well as grade-specific PC risk.

METHODS

We conducted a prospective cohort study of 6017 men who were enrolled in the Collaborative cohort study in the UK between 1970 and 1973 and followed up to 31st December 2007. Cox Proportional Hazards Models were used to evaluate the association between coffee consumption and overall, as well as Gleason grade-specific, PC incidence.

RESULTS

Higher coffee consumption was inversely associated with risk of high grade but not with overall risk of PC. Men consuming 3 or more cups of coffee per day experienced 55% lower risk of high Gleason grade disease compared with non-coffee drinkers in analysis adjusted for age and social class (HR 0.45, 95% CI 0.23-0.90, p value for trend 0.01). This association changed a little after additional adjustment for Body Mass Index, smoking, cholesterol level, systolic blood pressure, tea intake and alcohol consumption.

CONCLUSION

Coffee consumption reduces the risk of aggressive PC but not the overall risk.

Authors+Show Affiliations

Institute of Health & Wellbeing, College of Medical, Veterinary and Life Sciences, Public Health, University of Glasgow, 1 Lilybank Gardens, Glasgow G12 8RZ, UK. k.shafique.1@research.gla.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22695052

Citation

Shafique, Kashif, et al. "Coffee Consumption and Prostate Cancer Risk: Further Evidence for Inverse Relationship." Nutrition Journal, vol. 11, 2012, p. 42.
Shafique K, McLoone P, Qureshi K, et al. Coffee consumption and prostate cancer risk: further evidence for inverse relationship. Nutr J. 2012;11:42.
Shafique, K., McLoone, P., Qureshi, K., Leung, H., Hart, C., & Morrison, D. S. (2012). Coffee consumption and prostate cancer risk: further evidence for inverse relationship. Nutrition Journal, 11, p. 42. doi:10.1186/1475-2891-11-42.
Shafique K, et al. Coffee Consumption and Prostate Cancer Risk: Further Evidence for Inverse Relationship. Nutr J. 2012 Jun 13;11:42. PubMed PMID: 22695052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption and prostate cancer risk: further evidence for inverse relationship. AU - Shafique,Kashif, AU - McLoone,Philip, AU - Qureshi,Khaver, AU - Leung,Hing, AU - Hart,Carole, AU - Morrison,David S, Y1 - 2012/06/13/ PY - 2012/02/23/received PY - 2012/06/13/accepted PY - 2012/6/15/entrez PY - 2012/6/15/pubmed PY - 2013/2/7/medline SP - 42 EP - 42 JF - Nutrition journal JO - Nutr J VL - 11 N2 - BACKGROUND: Higher consumption of coffee intake has recently been linked with reduced risk of aggressive prostate cancer (PC) incidence, although meta-analysis of other studies that examine the association between coffee consumption and overall PC risk remains inconclusive. Only one recent study investigated the association between coffee intake and grade-specific incidence of PC, further evidence is required to understand the aetiology of aggressive PCs. Therefore, we conducted a prospective study to examine the relationship between coffee intake and overall as well as grade-specific PC risk. METHODS: We conducted a prospective cohort study of 6017 men who were enrolled in the Collaborative cohort study in the UK between 1970 and 1973 and followed up to 31st December 2007. Cox Proportional Hazards Models were used to evaluate the association between coffee consumption and overall, as well as Gleason grade-specific, PC incidence. RESULTS: Higher coffee consumption was inversely associated with risk of high grade but not with overall risk of PC. Men consuming 3 or more cups of coffee per day experienced 55% lower risk of high Gleason grade disease compared with non-coffee drinkers in analysis adjusted for age and social class (HR 0.45, 95% CI 0.23-0.90, p value for trend 0.01). This association changed a little after additional adjustment for Body Mass Index, smoking, cholesterol level, systolic blood pressure, tea intake and alcohol consumption. CONCLUSION: Coffee consumption reduces the risk of aggressive PC but not the overall risk. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/22695052/Coffee_consumption_and_prostate_cancer_risk:_further_evidence_for_inverse_relationship_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-11-42 DB - PRIME DP - Unbound Medicine ER -