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The protein tyrosine phosphatase nonreceptor 22 C1858T polymorphism and vasculitis: a meta-analysis.
Mol Biol Rep. 2012 Aug; 39(8):8505-11.MB

Abstract

The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to vasculitis. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across nine comparative studies containing 1,922 vasculitis patients and 11,505 normal control subjects. Meta-analysis showed no association between the T allele and vasculitis in all subjects [odds ratio (OR) 1.046, 95 % confidence interval (CI) 0.755-1.1.451, p = 0.786], and analysis after stratification by ethnicity indicated that the T allele was not associated with vasculitis in Europeans (OR 1.104, 95 % CI 0.798-1.528, p = 0.551). However, meta-analysis showed a significant association between the T allele and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) (OR 1.415, 95 % CI 1.228-1.630, p = 1.59 × 10(-6)) and Wegener's granulomatosis (WG) (OR 1.829, 95 % CI 1.377-2.431, p = 3.09 × 10(-5)). In addition, meta-analysis showed an association between the T allele and WG in ANCA-positive subjects (OR 2.042, 95 % CI 1.534-2.719, p = 1.02 × 10(-6)), but not in ANCA-negative WG patients (OR 0.595, 95 % CI 0.199-1.781, p = 0.353). This meta-analysis does not show that the PTPN22 C1858T polymorphism is associated with vasculitis susceptibility, but does show that this polymorphism is associated with susceptibility to AAV, WG, and ANCA status in WG.

Authors+Show Affiliations

Division of Rheumatology, Department of Internal Medicine, Korea University, Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea. lyhcgh@korea.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22696186

Citation

Lee, Young Ho, et al. "The Protein Tyrosine Phosphatase Nonreceptor 22 C1858T Polymorphism and Vasculitis: a Meta-analysis." Molecular Biology Reports, vol. 39, no. 8, 2012, pp. 8505-11.
Lee YH, Choi SJ, Ji JD, et al. The protein tyrosine phosphatase nonreceptor 22 C1858T polymorphism and vasculitis: a meta-analysis. Mol Biol Rep. 2012;39(8):8505-11.
Lee, Y. H., Choi, S. J., Ji, J. D., & Song, G. G. (2012). The protein tyrosine phosphatase nonreceptor 22 C1858T polymorphism and vasculitis: a meta-analysis. Molecular Biology Reports, 39(8), 8505-11. https://doi.org/10.1007/s11033-012-1705-x
Lee YH, et al. The Protein Tyrosine Phosphatase Nonreceptor 22 C1858T Polymorphism and Vasculitis: a Meta-analysis. Mol Biol Rep. 2012;39(8):8505-11. PubMed PMID: 22696186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The protein tyrosine phosphatase nonreceptor 22 C1858T polymorphism and vasculitis: a meta-analysis. AU - Lee,Young Ho, AU - Choi,Sung Jae, AU - Ji,Jong Dae, AU - Song,Gwan Gyu, Y1 - 2012/06/14/ PY - 2012/02/23/received PY - 2012/06/06/accepted PY - 2012/6/15/entrez PY - 2012/6/15/pubmed PY - 2012/11/14/medline SP - 8505 EP - 11 JF - Molecular biology reports JO - Mol. Biol. Rep. VL - 39 IS - 8 N2 - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to vasculitis. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across nine comparative studies containing 1,922 vasculitis patients and 11,505 normal control subjects. Meta-analysis showed no association between the T allele and vasculitis in all subjects [odds ratio (OR) 1.046, 95 % confidence interval (CI) 0.755-1.1.451, p = 0.786], and analysis after stratification by ethnicity indicated that the T allele was not associated with vasculitis in Europeans (OR 1.104, 95 % CI 0.798-1.528, p = 0.551). However, meta-analysis showed a significant association between the T allele and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) (OR 1.415, 95 % CI 1.228-1.630, p = 1.59 × 10(-6)) and Wegener's granulomatosis (WG) (OR 1.829, 95 % CI 1.377-2.431, p = 3.09 × 10(-5)). In addition, meta-analysis showed an association between the T allele and WG in ANCA-positive subjects (OR 2.042, 95 % CI 1.534-2.719, p = 1.02 × 10(-6)), but not in ANCA-negative WG patients (OR 0.595, 95 % CI 0.199-1.781, p = 0.353). This meta-analysis does not show that the PTPN22 C1858T polymorphism is associated with vasculitis susceptibility, but does show that this polymorphism is associated with susceptibility to AAV, WG, and ANCA status in WG. SN - 1573-4978 UR - https://www.unboundmedicine.com/medline/citation/22696186/The_protein_tyrosine_phosphatase_nonreceptor_22_C1858T_polymorphism_and_vasculitis:_a_meta_analysis_ L2 - https://doi.org/10.1007/s11033-012-1705-x DB - PRIME DP - Unbound Medicine ER -